Person: CÜCÜ, AYŞEN
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CÜCÜ
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AYŞEN
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Publication Open Access Determination and stability of some international screening limited drugs in equine blood by LC-MS/MS(ANKARA UNIV PRESS, 2019-10-01) CÜCÜ, AYŞEN; Goktas, Eylem Funda; Kabil, Erol; Gunes, Ertugrul; Korkmaz, Serol; Kadioglu, Tuba Asena; Cucu, Aysen KurtStability of some international screening limited therapeutic substances for doping control in equine blood has been investigated with a validated method by using LC-MS/MS after chemical hydrolysis with orthophosphoric acid. Whole blood samples were extracted with a WAX cartridge on auto-SPE. Stability test of the drug substances performed at the same time in working solution and matrix at +4 degrees C, -20 degrees C, +20 degrees C in dark and +20 degrees C in light conditions for 1, 2, 3 and 4 weeks. For short-time stability, the effects of 6 h storage at +55 degrees C was also investigated. Repeated data were statistically analyzed with ANOVA. All substances in working solution were stable at -20 degrees C and +4 degrees C. In the blood matrix, higher temperatures (+20 degrees C) in light and dark caused degradation of substances at the end of four weeks and short-term study (P<0.05). In conclusion, these international screening limited substances in blood matrix could be unstable related to temperature and storage time, although in working solution they could be mostly stable in various temperatures for four weeks.Publication Open Access Quantitative Determination of The Heavy Metals (Lead, Zinc And Manganese) in White Cheese Produced in Ergene Basin by Using Atomic Absorption Spectrophotometry(MARMARA UNIV, FAC PHARMACY, 2015-04-09) CÜCÜ, AYŞEN; Cucu, Aysen Kurt; Yavuz, Mustafa; Demir, Hulya DemircanIt is well known that heavy metals are harmful for human health appearing only after exceeding the specific concentrations of each metal. This study was carried out to determine the concentrations of heavy metals in cheese that was produced in diaries of Ergene Basin. The dairies near the Ergene River were investigated and suitable ones were selected. Since the sampling process directly affects the sensitivity of the results, particular attention was given to this process. A total of twelve samples of cheese were collected from different diaries and each samples were digested three times by dry ashing and wet ashing methods and totally 108 cheese samples were obtained for metal analyses. The lead, manganese content of the cheese samples were measured by graphite furnace atomic absorption spectrophotometer and zinc content of the cheese samples were measured by flame atomic absorption spectrophotometer. Contents of heavy metals in the examined samples were compared with the excepted limit values in the literature and the results were evaluated. Experimental data shows that the concentrations of heavy metals are in the range of accepted limit values.Publication Open Access İstanbul Aktarlarında Satılan Bitkisel Çaylarda Ağır Metal Tayini(2015-04-17) CÜCÜ, AYŞEN