Person: CESUR, SÜMEYYE
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CESUR
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SÜMEYYE
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Publication Metadata only Keratin loaded pva/silk fibroin electrospun nanofibers for wound dressing applications(2022-11-26) CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Tut T. A., Cesur S., Gündüz O.Publication Metadata only Fabrication and characterization of naringenin-loaded poly(lactic acid) (pla) nanofibrous scaffolds(2022-11-26) BİLĞİÇ ALKAYA, DİLEK; CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Erdağ Z., Yeşil E., Bilğiç Alkaya D., Cesur S., Gündüz O.Publication Metadata only Fabrication, characterization and investigation of antibacterial activity of propolis substituted sodium alginate tissue scaffolds using three-dimensional (3d) printing technology(2021-06-05) UZUN, MUHAMMET; SU TORUN, SENA; ULAĞ, SONGÜL; AKSU, MEHMET BURAK; GÜNDÜZ, OĞUZHAN; CESUR, SÜMEYYE; Aarancı K., Uzun M., Su Torun S., Cesur S., Ulağ S., Amin A., Güncü M. M., Aksu M. B., Kolaylı S., Silva J., et al.Publication Metadata only Development of Electrospun Nanofibers Containing Gentamicin and Cinnamaldehyde for Treating Corneal Infections(2023-06-30) CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Tut T. A., Cesur S., Ilhan E., Gawrońska E. K., Gündüz O.Publication Metadata only Development of janus microbubbles with varied morphologies by the effect of different solvents(2022-11-26) CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; Yeşilyurt T., Cesur S., Üstündağ C. B., Gündüz O.Publication Metadata only Controlled release of donopezil-loaded polyvinyl alcohol (pva) microbubbles/nanoparticles using microfluidic t-junction device(2020-09-18) CESUR, SÜMEYYE; ÇAM, MUHAMMET EMİN; GÜNDÜZ, OĞUZHAN; Cesur S., Çam M. E., Gündüz O.Production of donepezil- loaded microbubble/nanoparticles for treatment of Alzheimer diseasePublication Metadata only Inula helenium extract-loaded nanofibrous patches for the treatment of cancer(2023-06-30) CESUR, SÜMEYYE; BİLĞİÇ ALKAYA, DİLEK; GÜNDÜZ, OĞUZHAN; Sulutas R. B., Cesur S., Ayaz-Seyhan S., Bilğiç Alkaya D., Gündüz O.Publication Metadata only Inula helenium loaded nanofibers mat for medical application(2023-06-28) CESUR, SÜMEYYE; AYAZ SEYHAN, SERAP; BİLĞİÇ ALKAYA, DİLEK; GÜNDÜZ, OĞUZHAN; SULUTAŞ R. B., CESUR S., AYAZ SEYHAN S., BİLĞİÇ ALKAYA D., GÜNDÜZ O.Cancer is one of the leading causes of death worldwide. Biomaterials produced with nanotechnological methods for cancer treatment are more effective and complementary than existing treatment strategies. Nanofiber scaffolds are biomaterials that can be used in cancer treatment and can be produced in composites with biocompatible polymers and anti-cancer drugs, plant extracts. The electrospin device used for the production of these materials creates nanofiber networks by providing the electric field between the needle tip and the metal collector, which transmits the polymer solution. PLA is a biodegradable synthetic material preferred in tissue engineering studies and is a biocompatible, high mechanical strength, low cost polymer suitable for use in drug delivery systems. PVP is a polymer with good adhesion, high physiological compatibility, low toxicity and easily soluble in most organic solvents, especially used in the pharmaceutical industry. The extract of the plant Inula helenium, whose main component consists of sesquiterpene lactones, is also used in treatments for cancer. This component, which has various biological activities, has a significant anti-cancer effect. In this study, the polymer ratio used in the production of nanofiber scaffold obtained by adding Inula helenium extract is 75% PLA-chloroform / 25% PVP-ethanol and 1% Tween 80. The surface morphology of the produced fiber material was determined according to the results in the SEM images. The diameters of the fibers were measured and given in the histogram graph. FT-IR for chemical structure between bonds and DSC tests for thermal behavior analysis were applied. Tensile test was performed for mechanical analysis. Swelling-degradation test was performed and drug release kinetic data were calculated by UV spectrophotometer. In addition, its effectiveness on cancerous cells was examined by MTT analysis. In conclusion, Inula helenium extract-loaded nanofibers can reduce the risk of local recurrence of cancer after surgery and can be directly implanted into solid tumor cells for treatmentPublication Open Access Microfluidic systems for neural tissue engineering(Elsevier Science, Oxford/Amsterdam , 2023-01-01) CESUR, SÜMEYYE; ULAĞ, SONGÜL; GÜNDÜZ, OĞUZHAN; Cesur S., Ulağ S., Gündüz O.Damage to the nervous system due to illness or injury can cause serious and lasting loss of function or even fatal consequences. It is necessary to develop new treatment strategies to restore the function of the damaged nervous system.The optimal environment for nerve cell proliferation and differentiation is provided by neural tissue engineering. It aims to improve a new approximation for the therapy of nervous system diseases. Compared to 2D cell culture techniques, 3D cell culture systems ensure a more biomimetic environment and encourage more differentiation of cells. However, certain cell culture parameters have limitations in spatio-temporal control. With the advent of microfluidic systems, it can control the spatio-temporal dispersion of physical and chemical signals at the cellular level. In this section, microfluidic systems are explored as a tool to target both physical and chemical injury and recreate the post-injury environment, to study nerve injury at the cellular grade.Publication Open Access The Role of Multilayer Electrospun Poly(Vinyl Alcohol)/Gelatin nanofibers loaded with Fluconazole and Cinnamaldehyde in the Potential Treatment of Fungal Keratitis(2022-08-01) GÜNDÜZ, OĞUZHAN; TINAZ, GÜLGÜN; ŞENGÖR, MUSTAFA; CESUR, SÜMEYYE; Ilhan E., Cesur S., Sulutas R. B., Pilavci E., Dalbayrak B., Kaya E., Arisan E. D., Tinaz G., ŞENGÖR M., Kijeenska-Gawaronska E., et al.Fungal keratitis is a severe corneal infection that causes irreversible damage to the cornea, for which conventional drug treatments may be insufficient. With the new generation of drug delivery systems, it is desired to ensure the ocular usability of drugs. In this study, two-layer polyvinyl alcohol and gelatin (PVA/GEL) nanofibers with high drug loading capacity were produced by the electrospinning method. Cinnamaldehyde (CA), an FDAapproved volatile molecule found in cinnamon essential oil, and fluconazole (FLU), an antifungal drug, were incorporated into PVA/GEL nanofibers to inhibit the growth and biofilm formation of Candida albicans, one of the pathogens that cause fungal keratitis. The morphology, chemical structures, and thermal transitions of the produced pure (PVA/GEL), FLU loaded (PVA/GEL/FLU), CA loaded (PVA/GEL/CA), and combined FLU and CA loaded (PVA/GEL/COM) nanofibers were analysed by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC), respectively. The mechanical analysis, swelling and degradation behaviour, and drug release kinetics of the nanofibers were investigated. PVA/ GEL/FLU, PVA/GEL/CA and PVA/GEL/FLU/COM nanofibers were evaluated for their antifungal and antibiofilm activity against Candida albicans. Results showed that PVA/GEL/FLU and PVA/GEL/COM nanofibers have significant antifungal activity and inhibited biofilm formation by 37% and 49%, respectively. Furthermore, it was determined by MTT analysis using a human embryonic kidney (HEK) that the nanofibers were not cytotoxic. In the treatment of fungal keratitis, double-layer PVA/GEL/COM nanofiber with CA in the first layer and FLU in the second layer can create a new treatment approach as an alternative drug delivery system.