Person: BOZKURTLAR, EMİNE
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BOZKURTLAR
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EMİNE
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Publication Metadata only Protective effect of cysteinyl leukotriene receptor antagonist montelukast in bleomycin-induced pulmonary fibrosis(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2018) CEYHAN, BERRİN; Topaloglu, Nurhayat; Yildizeli, Sehnaz Olgun; Sener, Goksel; Lacin, Tunc; Sehirli, Ozer; Bozkurtlar, Emine; Celikel, Cigdem; Ceyhan, BerrinBackground: This study aims to investigate the early- and late-term effects of pharmacological inhibition of cysteinyl leukotriene activity by using montelukast in bleomycin-induced inflammatory and oxidative lung injury in an animal model. Methods: The study included 48 male Wistar albino rats (weighing 250 g to 300 g). Rats were administered intratracheal bleomycin or saline and assigned into groups to receive montelukast or saline. Bronchoalveolar lavage fluid and lung tissue samples were collected four and 15 days after bleomycin administration. Results: Bleomycin resulted in significant increases in tumor necrosis factor-alpha levels (4.0 +/- 1.4 pg/mL in controls vs. 44.1 +/- 14.5 pg/mL in early-term vs. 30.3 +/- 5.7 pg/mL in late-term, p<0.001 and p<0.001, respectively), transforming growth factor beta 1 levels (28.6 +/- 6.6 pg/mL vs. 82.3 +/- 14.1 pg/mL in early-term vs. 60.1 +/- 2.9 pg/mL in late-term, p<0.001 and p<0.001, respectively), and fibrosis score (1.85 +/- 0.89 in early-term vs. 5.60 +/- 1.14 in late-term, p<0.001 and p<0.01, respectively). In bleomycin exposed rats, collagen content increased only in the late-term (15.3 +/- 3.0 mu g/mg in controls vs. 29.6 +/- 9.1 mu g/mg in late-term, p<0.001). Montelukast treatment reversed all these biochemical indices as well as histopathological alterations induced by bleomycin. Conclusion: Montelukast attenuates bleomycin-induced inflammatory and oxidative lung injury and prevents lung collagen deposition and fibrotic response. Thus, cysteinyl leukotriene receptor antagonists might be regarded as new therapeutic agents for idiopathic pulmonary fibrosis.Publication Metadata only Endobronchial ultrasound transbronchial needle aspiration in elderly patients: safety and performance outcomes EBUS-TBNA in elderly(TAYLOR & FRANCIS LTD, 2020) TUFAN ÇİNÇİN, ASLI; Yildizeli, Sehnaz Olgun; Tufan, Asli; Bozkurtlar, Emine; Arikan, Huseyin; Kocakaya, Derya; Eryuksel, Emel; Ceyhan, Berrin; Karakurt, SaitAim Complication rates are low and endobronchial ultrasound guided needle aspiration (EBUS-TBNA) is generally regarded as a safe procedure, but there is a very limited number of studies evaluating the efficacy and safety of the procedure in advanced ages. The aim of this study is to assess the safety and performance outcomes of EBUS-TBNA in elderly. Methods It was a retrospective observational study; patients who received EBUS-TBNA between September 2016 and January 2018 were evaluated. We analyzed patient's characteristics, doses of midazolam, and lidocaine used, regions of lymph node biopsies, and complications. Also, functionality and general physical status of patients over 65 years of age were evaluated. Results During study period 132 cases of EBUS-TBNA were evaluated. 39 (29.5%) cases were aged 70 years, and over. There were more comorbidities in older group. Performance status of older group was worse. Furthermore, when evaluated according to American College of Cardiology (ACC)/American Heart Association (AHA) and American Society of Anesthesiologists (ASA), the older group was found to be composed of the riskier patients. When patients aged between 65 and 69, and over 70 compared, older patient's Barthel, EQ 5-D, SGA, and G8 scores were found to be worse. Despite that, there was no difference in the frequency, and types of complications between both groups. Diagnostic performance was not different between age groups. Conclusions Independent from comorbidities, general health status, and functionality EBUS-TBNA procedure in 70-year-old and over patients is a safe minimally invasive procedure.Publication Metadata only Pulmoner nodül rezeksiyonu yapılan olgularda klinik radyolojik bulguların malign histopatolojik tanılar ile korelasyonu(2023-05-09) OLGUN YILDIZELİ, ŞEHNAZ; KOCAKAYA, DERYA; ERMERAK, NEZİH ONUR; BOZKURTLAR, EMİNE; ERYÜKSEL, SEMİHA EMEL; ÇİMŞİT, NURİ ÇAGATAY; YILDIZELİ, BEDRETTİN; KARAKURT, SAİT; OLGUN YILDIZELİ Ş., GİVİVİ S., KOCAKAYA D., ERMERAK N. O., BOZKURTLAR E., ERYÜKSEL S. E., ÇİMŞİT N. Ç., YILDIZELİ B., KARAKURT S.Pulmonary nodules are common (nc(dental f(nd(ng on thorac(c computed tomography (CT) and st(ll a problem (n da(ly pulmonary pract(ce. Because of the w(dely usage of CT scans an (ncreased number of pat(ents follow up w(th th(s d(agnose. Nodules may or(g(nated secondary to ben(gn d(seases but pr(mary concern (s mal(gnanc(es wh(ch (s (mportant for early d(agnos(s and curat(ve opt(ons. On the other hand (t (s not cost-effect(ve follow(ng up the ben(gn les(ons w(th an add(t(onal cumulat(ve rad(at(on dose espec(ally (n prolonged durat(on. Many pred(ct(on models were proposed to evaluate the potency of mal(gnancy us(ng cl(n(cal and rad(olog(cal f(nd(ngs Mayo cl(n(c (1), Veterans Assoc(at(on (2), Brock Un(vers(ty (3) and lastly Herder model (4) mostly used models for r(sk strat(f(cat(on. Herder r(sk model evaluates also Flour(ne– flourodeoxyglucose (FDG) uptake (n pos(tron em(ss(on tomography-computed tomography (PET-CT). Comparat(ve study of these models showed non-super(or(ty to each other, added value of PET-CT (s unden(able for larger nodules but not clear for small nodules (< 8mm) (5). Mult(d(sc(pl(nary follow up, careful observat(on and d(agnost(c test(ng are st(ll h(ghly recommended espec(ally for (ndeterm(ne nodulesPublication Metadata only Pulmoner arter sarkomanın cerrahi sonuçları: Histoloji sağkalımı etkiler mi(2023-08-01) BOZKURTLAR, EMİNE; OLGUN YILDIZELİ, ŞEHNAZ; MUTLU, BÜLENT; KOCAKAYA, DERYA; BEKİROĞLU, GÜLNAZ NURAL; YILDIZELİ, BEDRETTİN; Başar V., Olgun Yıldızeli Ş., Bozkurtlar E., Ercelep ., Mutlu B., Kocakaya D., Bekiroğlu G. N., Taş S., Sunar H., Küçükoğlu M. S., et al.