Person: KOCAKAYA, DERYA
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KOCAKAYA
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DERYA
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Publication Open Access Outcome of solid and cavitary pulmonary nodules in rheumatoid arthritis patients— case series(2022-01-01) AKSOY, AYSUN; BOZKURTLAR, EMİNE; KARAKURT, SAİT; ERYÜKSEL, SEMİHA EMEL; İNANÇ, GÜZİDE NEVSUN; KOCAKAYA, DERYA; AKSOY A., KOCAKAYA D., Yalçinkaya Y., BOZKURTLAR E., KARAKURT S., Eryüksel E., İnanç N.© TÜBİTAK.Background/aim: Rheumatoid pulmonary nodule can be detected in up to 32% of rheumatoid arthritis (RA) patients and approximately one-third of nodules may cavitate. We aimed to evaluate characteristics of patients with RA developing cavitary pulmonary nodular (CPN) lesions under disease-modifying antirheumatic drugs (DMARDs), follow-up of both cavitary and solid nodules, and their outcome with the treatment. Materials and methods: RA patients who presented with CPN lesions during follow-up were recruited retrospectively in this case series analysis. Total numbers and mean diameters of cavitary and solid nodules in each thorax computed tomography (CT) have been determined and followed up by two experienced pulmonary physicians. Moreover, changes in treatment after the development of the CPN lesions and characteristics of cavitary nodules were collected. Results: Eleven patients with CPN lesions were reported. At the time of CPN diagnosis, more patients were taking leflunomide than methotrexate (81% vs 19%). Half of the patients were receiving biologic therapy and only 18% were taking anti-TNF drugs. After a median of 24 (3–65) months of follow-up, the regression of CPN lesions was determined in 45% (5/11) of patients. Four of these 5 (80%) patients were switched to a treatment regimen without leflunomide and three of them to nonanti-TNF biologic treatment or targeted synthetic DMARDs (tocilizumab, tofacitinib, and rituximab). Conclusion: CPN lesions seen in RA patients are often pulmonary manifestations of the underlying disease; however, one must rule out malignancies or infections. If lesions progress under DMARDs, it is advised to discontinue synthetic DMARDs (LEF/MTX) and switch to another biological DMARD with different modes of action.Publication Metadata only İlerı ve son evre akciğer hastalığına ikincil solunum yetmezliği olan hastaların bakım verenlerinde bakım verici yükü ve depresyon ilişkisi(2018-04-18) OLGUN YILDIZELİ, ŞEHNAZ; KASAPOĞLU, UMUT SABRİ; KOCAKAYA, DERYA; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; KARAKURT, SAİT; ARIKAN, HÜSEYİN; OLGUN YILDIZELİ Ş., ARIKAN H., KASAPOĞLU U. S., KOCAKAYA D., ERYÜKSEL S. E., CEYHAN B., KARAKURT S.Publication Open Access The role of procalcitonin as a biomarker for acute pulmonary exacerbation in subjects with cystic fibrosis and non-cystic fibrosis bronchiectasis(2022-01-01) KOCAKAYA, DERYA; ARIKAN, HÜSEYİN; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; Mammadov F., Olgun Yildizel S., Kocakaya D., ARIKAN H., Cinar C., Eryuksel E., CEYHAN B.Objective: Patients with cystic fibrosis (CF) and non-CF bronchiectasis are prone to exacerbations of pulmonary infections. C-reactive protein (CRP) and procalcitonin (PCT) are inflammatory markers. The aim of this study is to evaluate the role of CRP and PCT on exacerbations of CF and non-CF bronchiectasis. Patients and Methods: The medical records of 18 CF (52 hospitalizations) and 20 non-CF bronchiectasis patients (51 hospitalizations) were reviewed retrospectively. CRP, PCT levels and, white blood cell (WBC) counts on admission and follow-up were evaluated. Results: C-reactive protein levels correlated with PCT levels on admission in all patients. Baseline PCT levels were markedly higher (>0.5µg/L) in 12% of CF and 10% of non-CF bronchiectasis patients, however, baseline CRP values were markedly higher (>5mg/L) in 96% of CF and non-CF bronchiectasis patients (p=0.760 and p=0.100, respectively). Baseline CRP and PCT levels were positively correlated with hospitalization length (r=0.501, p=0.001 and r=0.289, p=0.04, respectively) in CF patients, but not in non-CF bronchiectasis. Conclusion: Our study shows the potential utility of these biomarkers to determine the severity of the exacerbation particularly predicting hospitalization length in CF patients. Both biomarkers could be able to guide antibiotic treatment of infective exacerbations in CF and non-CF bronchiectasis patients.Publication Metadata only The predictive role of psychological status and disease severity indexes on quality of life among patients with non-CF bronchiectasis(2022-01-01) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; CEYHAN B., Bekir M., KOCAKAYA D., OLGUN YILDIZELİ Ş., ERYÜKSEL S. E.OBJECTIVE: Bronchiectasis is a chronic suppurative lung disease that significantly impacts the patients\" quality of life. The aim of this study is to evaluate the relationship between quality of life and patient\"s psychological status and bronchiectasis disease severity indexes in patients with non-cystic fibrosis bronchiectasis. We also aimed to investigate the validity and reliability of Turkish version of Quality of Life Questionnaire-Bronchiectasis (V3.1) in Turkish adult bronchiectatic patients.Publication Metadata only Impact of body composition and nutritional status on health outcomes in adultcystic fibrosis patients(2019-04-18) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; USLU N. Z. , KOCAKAYA D., OLGUN YILDIZELİ Ş., ERYÜKSEL S. E. , GÖRÇİN KARATEKİR Ş., CEYHAN B.AIM: Cystic fibrosis (CF) is a multi-systemic disease. Chronic inflammation and malabsorption may affect body composition, respiratory function and health outcomes. Our aim was to examine anthropometric measures, microbiologic data, spirometric data, comorbidities and how body composition may impact health outcomes in adult CF patients. METHODS: 31 adult CF patients (15 female, 16 male) with mean age 25 (18-42) and 23 controls were enrolled. The modified Medical Research Council (mMRC) scale, 6 minute-walk-test and pulmonary function test were performed. Anthropometric data including body mass index (BMI), fat-free mass index (FFMI) and total body fat percentiles were measured. Clinical indices, presence/absence of pancreatic insufficiency and method of nutrition were recorded. RESULTS: Mean duration of disease was 18.6±7.5 years. 24 of the patients (77%) were below targeted BMI. Mean BMI of the patients was 20.6±3.1 kg/m2 and mean FFMI was 16.4±1.6 kg/m2. When compared to control group, both BMI and FFMI were lower in CF patients (p<0.05 and 0.00) and both were correlated with age ( p: 0.008, r: 0.468 and p: 0.036, r:0.377). Female patients had lower FFMI (15.7±1.3 vs17.1±1.6, p:0.01) and higher fat percentile (22.7% vs 12.5%, p:0.00) than male patients. FFMI was found to be positively correlated with FEV1L and FVC L (p:0.017, r: 0.025 and p:0.05 and r: 0.490, respectively). 20 patients (65%) had pancreatic insufficiency and all were under pancreatic enzyme replacement medication. This group of patients had lower fat percentile then the group without pancreatic insufficiency (15.0±6.7% vs 23.2±9.0%; p:0.011) 16 patients (52%) had anemia and FFMI positively correlated with hemoglobin values (p:0.03, r: 0.390). 17 patients (55%) were receiving oral nutritional support and these patients had lower BMI then those who were not receiving (19.4±2.6 vs 22.1±2.9, p: 0.013). CONCLUSION: The prevalence of malnutrition was high in adult CF patients and lung function is correlated with nutritional status. Periodic measurement of anthropometrics and close monitoring of nutritional status may improve respiratory function and health outcomes in adult CF patientsPublication Metadata only Endobronchial ultrasound transbronchial needle aspiration in elderly patients: safety and performance outcomes EBUS-TBNA in elderly(TAYLOR & FRANCIS LTD, 2020) TUFAN ÇİNÇİN, ASLI; Yildizeli, Sehnaz Olgun; Tufan, Asli; Bozkurtlar, Emine; Arikan, Huseyin; Kocakaya, Derya; Eryuksel, Emel; Ceyhan, Berrin; Karakurt, SaitAim Complication rates are low and endobronchial ultrasound guided needle aspiration (EBUS-TBNA) is generally regarded as a safe procedure, but there is a very limited number of studies evaluating the efficacy and safety of the procedure in advanced ages. The aim of this study is to assess the safety and performance outcomes of EBUS-TBNA in elderly. Methods It was a retrospective observational study; patients who received EBUS-TBNA between September 2016 and January 2018 were evaluated. We analyzed patient's characteristics, doses of midazolam, and lidocaine used, regions of lymph node biopsies, and complications. Also, functionality and general physical status of patients over 65 years of age were evaluated. Results During study period 132 cases of EBUS-TBNA were evaluated. 39 (29.5%) cases were aged 70 years, and over. There were more comorbidities in older group. Performance status of older group was worse. Furthermore, when evaluated according to American College of Cardiology (ACC)/American Heart Association (AHA) and American Society of Anesthesiologists (ASA), the older group was found to be composed of the riskier patients. When patients aged between 65 and 69, and over 70 compared, older patient's Barthel, EQ 5-D, SGA, and G8 scores were found to be worse. Despite that, there was no difference in the frequency, and types of complications between both groups. Diagnostic performance was not different between age groups. Conclusions Independent from comorbidities, general health status, and functionality EBUS-TBNA procedure in 70-year-old and over patients is a safe minimally invasive procedure.Publication Metadata only The evaluation of lung ct densitometry in interstitial lung diseases(2020-05-05) KOCAKAYA, DERYA; ERYÜKSEL, SEMİHA EMEL; İNANÇ, GÜZİDE NEVSUN; ÇİMŞİT, NURİ ÇAGATAY; ŞENGÜL Y., KOCAKAYA D., ILGIN C., ERYÜKSEL S. E. , İNANÇ G. N. , ÇİMŞİT N. Ç. , ŞENGÜL Y.Publication Metadata only Clinical impact of depression and anxiety in patients with non-cystic fibrosis bronchiectasis(TURKISH ASSOC TUBERCULOSIS & THORAX, 2020) CEYHAN, BERRİN; Bekir, Melahat; Kocakaya, Derya; Balcan, Baran; Olgun Yildizeli, Sehnaz; Eryuksel, Emel; Ceyhan, BerrinIntroduction: Bronchiectasis is a chronic suppurative disease characterized by abnormal bronchial dilatation. The nature of bronchiectasis may have negative impact on psychological status, however it is poorly studied in relation to clinical indices, particularly the severity of disease. Primary aim of this study is to detect depression and anxiety in patients with non-cystic fibrosis bronchiectasis and to evaluate its relationship with disease severity indexes. Materials and Methods: Ninety (male/female= 37/53; median age 45 years) stable non-cystic fibrosis bronchiectatic adult patients were enrolled into this study. Dyspnea scores, number of exacerbations and hospital admissions within the last year, body-mass index, pulmonary function tests, sputum cultures, bronchiectasis disease severity indexes (BSI and FACED) were assessed. Anxiety and depression were evaluated by using the Turkish version of the hospital anxiety and depression scale questionaire. Results: Anxiety was diagnosed in 30% of patients and depression was diagnosed in 41% of the participants. Female participants had significantly higher rates of depression (55% vs. 22%; p= 0.002). Exacerbation rates within the last year were higher among the subjects with anxiety, moreover, patients with depression had shorter duration of disease. 851 and FACED severity indexes increased with longer duration of disease (5.6 +/- 5.0 yrs in mild group vs. 10.1 +/- 9.2 yrs in moderate-to-severe group, p= 0.035 and 5.7 +/- 5.4 yrs in mild group vs. 12.1 +/- 9.7 yrs in moderate-to-severe group, p= 0.001, respectively), however, anxiety and depression were not related with BSI and FACED severity indexes. Conclusion: Patients with non-cystic fibrosis bronchiectasis have an increased risk for depression and anxiety. Duration of disease and higher exacerbation rate are related with psychological status and indexes increased with longer duration of disease. Lady detection and taking the necessary measures to improve the psychological state is necessary for the overall management of these patients.Publication Metadata only Malignite şüphesi ile tanı alan bir pulmoner amiloidosiz vakası(2018-04-11) KOCAKAYA, DERYA; ERMERAK, NEZİH ONUR; OLGUN YILDIZELİ, ŞEHNAZ; ERYÜKSEL, SEMİHA EMEL; AHISKALI, ASİYE RENGİN; KOCAKAYA D., ERMERAK N. O., ERÇETİN S. Y., OLGUN YILDIZELİ Ş., ERYÜKSEL S. E., AHISKALI A. R.Publication Metadata only Artmış D-Dimer ve pulmoner arter çapı değerleri, Türk COVID-19 hastalarında hastalık progresyonu ve artmış mortalite ile ilişkilidir(2021-05-18) OLGUN YILDIZELİ, ŞEHNAZ; KOCAKAYA, DERYA; ERTÜRK ŞENGEL, BUKET; KARAKURT, SAİT; ERYÜKSEL, SEMİHA EMEL; MERCANCI Z., ILGIN C., OLGUN YILDIZELİ Ş., KOCAKAYA D., BALCAN M. B. , ERTÜRK ŞENGEL B., KARAKURT S., ERYÜKSEL S. E.