Person: KOCAKAYA, DERYA
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KOCAKAYA
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DERYA
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Publication Metadata only Does preexisting immuncompromised status prevent mortality in COVID-19 patients: friend or foe?(2022-09-01) VEZİR, DUYGU; KOCAKAYA, DERYA; MERCANCI, ZEYNEP; KARAKURT, SAİT; Vezir D., Yildizeli S. O., KOCAKAYA D., Mercanci Z., Balcan B., Cinar C., Eryuksel E., KARAKURT S.Publication Metadata only QT interval prolongation related to afatinib treatment in a patient with metastatic non-small-cell lung cancer(MOSBY-ELSEVIER, 2020) KOCAKAYA, DERYA; Demircan, Nazim Can; Telli, Tugba Akin; Tuylu, Tugba Basoglu; Arikan, Rukiye; Kocakaya, Derya; Sahin, Ahmet Anil; Ercelep, Ozlem; Dane, Faysal; Yumuk, Perran FuldenAfatinib improves survival in metastatic non-small-cell lung cancer driven by activating epidermal growth factor receptor mutations. QT interval prolongation is a possible side effect of tar geted anticancer drugs, but this has not been reported before with afatinib. We report a case of metastatic pulmonary adenocarcinoma with epidermal growth factor receptor exon 19 deletion who was treated with first-line afatinib. The patient was started on afatinib with a total dose of 40 mg/day and experienced grade 3 (> 500 ms) QT interval prolongation in the seventh week. Dose was interrupted and then reduced to 30 mg/day after the event repeated. QT prolongation occurred only once with the reduced dose and radiologic oligoprogression was detected. Local therapy was performed and afatinib was continued as 30 mg/day. To the best of our knowledge, this case marks the first QT interval prolongation associated with afatinib. It is prudent to perform a baseline cardiologic evaluation and electrocardiogram monitoring in non-small cell lung cancer patients treated with this drug. (c) 2020 Elsevier Inc. All rights reserved.Publication Metadata only Pulmonary hypertension classification based on machine learning using standart chest x-ray : ata artificial intelligence study-1(2022-05-26) KOCAKAYA, DERYA; YILDIZELİ, BEDRETTİN; KIVRAK T., YAĞMUR B., ÇİÇEK YILMAZ D., YEŞİL E., ÇELİK A., YAYLA Ç., TEKİN TAK B., İYİGÜN U., ARABACI H. O. , SİNAN Ü. Y. , et al.Amaç: An accurate diagnosis of pulmonary hypertension (PH) is crucial to ensure that patients receive timely treatment. One of the used imaging models to detect pulmonary hypertension is the X-ray. Therefore, a new automated PH type classification model has been presented to depict the separation ability of deep learning for PH types Yöntem: We retrospectively enrolled 6642 images of patients with PH and the control group. A new X-ray image dataset was collected from a multicenter in this work.A transfer learning-based image classification model has been presented in classifying PH types. Bulgular: Our proposed model was applied to the collected dataset, and this dataset contains six categories (five PH and a nonPH). The presented deep feature engineering (computer vision) model attained 86.14% accuracy on this dataset. According to the extracted ROC curve, the average area under the curve rate has been calculated at 0.945.Publication Metadata only Predictors of health related quality of life in patients wi̇th pulmonary hypertension(2022-02-07) KOCAKAYA, DERYA; ATAŞ, HALİL; YILDIZELİ, BEDRETTİN; MUTLU, BÜLENT; KOCAKAYA D., ŞİŞMAN A., AKASLAN D., ATAŞ H., YILDIZELİ B., MUTLU B.Publication Metadata only İlerı ve son evre akciğer hastalığına ikincil solunum yetmezliği olan hastaların bakım verenlerinde bakım verici yükü ve depresyon ilişkisi(2018-04-18) OLGUN YILDIZELİ, ŞEHNAZ; KASAPOĞLU, UMUT SABRİ; KOCAKAYA, DERYA; ERYÜKSEL, SEMİHA EMEL; CEYHAN, BERRİN; KARAKURT, SAİT; ARIKAN, HÜSEYİN; OLGUN YILDIZELİ Ş., ARIKAN H., KASAPOĞLU U. S., KOCAKAYA D., ERYÜKSEL S. E., CEYHAN B., KARAKURT S.Publication Metadata only Histopathological evaluation of post-mortem pulmonary specimens excised from ICU patients with COVID-19: Do we know what we do not know(2023-05-06) ERMERAK, NEZİH ONUR; BOZKURTLAR, EMİNE; KOCAKAYA, DERYA; GÜL, FETHİ; KARAKURT, SAİT; ERMERAK N. O., BOZKURTLAR E., KOCAKAYA D., GÜL F., KARAKURT S., Cinel I.Publication Metadata only Eri̇şki̇n ki̇sti̇k fi̇brozi̇s hastalarinda İlaç uyumu ve anksi̇yete/depresyonu etki̇leyen faktörler(2018-05-18) KOCAKAYA, DERYA; OLGUN YILDIZELİ, ŞEHNAZ; CEYHAN, BERRİN; USLU N. Z. , KOCAKAYA D., OLGUN YILDIZELİ Ş., CEYHAN B.Publication Metadata only Treatment of respiratory infections in pregnant patients: overview(Springer Nature, 2022-01-01) KOCAKAYA, DERYA; BAŞLILAR Ş., KOCAKAYA D., YORGANCIOĞLU A. A.It is reported that antibiotics represent almost 80% of the drugs prescribed to pregnant women and that between 1 in 5 and 1 in 4 pregnant women are administered antibiotic pharmacotherapy [1–3]. In pregnant women, the most frequently occurring infections are urinary tract infections (UTIs) (cystitis and pyelonephritis), venereal infections and the upper respiratory tract infections (URTIs)Publication Metadata only THE EFFECT OF GLOBAL LONGITUDINAL STRAIN ON IMPAIRED SIX-MINUTE WALK TEST PERFORMANCE IN PATIENTS WITH SARCOIDOSIS(MATTIOLI 1885, 2020) KEPEZ, ALPER; Ozen, Deniz Kaptan; Mutlu, Bulent; Kocakaya, Derya; Turan, Burak; Sekerci, Sena Sert; Ceyhan, Berrin; Kepez, Alper; Erdogan, OkanBackground: Sarcoidosis is a multisystem and granulomatous disease associated with impaired functional capacity as a result of pulmonary and cardiac involvement. Factors adversely effecting functional capacity in patients with sarcoidosis have not been systematically assessed including myocardial strain imaging on echocardiography which enable to diagnose subclinical cardiac dysfunction. We aimed to evaluate the effect of left and right ventricular global longitudinal strain (GLS) on submaximal exercise capacity in patients with sarcoidosis who do not have clinically manifest cardiac involvement. Methods: Extracardiac biopsy proven 56 patients with sarcoidosis and 26 controls were included consecutively. Submaximal exercise capacity of the subjects was assessed with six-minute walk test (6 MWT). Pulmonary function tests and standard transthoracic and two-dimensional speckle tracking echocardiography were performed to the all subjects. Linear regression analysis was performed to find independent predictors of 6 MWT. Results: Fifty-six patients (18% male) with a mean age of 52.5 +/- 10.7 years were included. Patients with sarcoidosis had low 6 MWT performance and higher New York Heart Association classes and NT-proBNP levels. There were no significant differences between controls and patients with sarcoidosis in parameters of pulmonary function test. Biventricular GLS levels and biatrial reservoir and conduit function values were lower and systolic pulmonary artery pressure (SPAP) was significantly higher in patients with sarcoidosis as compared with controls. Older age and higher SPAP were found as independent predictors of poor 6 MWT performance. Conclusion: Although biventricular GLS levels were lower in the patients with sarcoidosis, only age and SPAP elevations were independent predictors of the submaximal exercise capacity.Publication Metadata only KOAH hastalarında D vitamini düzeyinin kilinik bulgularla ilişkisi(2021-05-18) KOCAKAYA, DERYA; CEYHAN, BERRİN; KOCAKAYA D., KOCAKAYA O., CEYHAN B.