Person: KORTEN, VOLKAN
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
KORTEN
First Name
VOLKAN
Name
5 results
Search Results
Now showing 1 - 5 of 5
Publication Open Access An outbreak investigation of Burkholderia cepacia infections related with contaminated chlorhexidine mouthwash solution in a tertiary care center in Turkey(BMC, 2021-12) GÜL, FETHİ; Bilgin, Huseyin; Gelmez, Gulsen Altinkanat; Bayrakdar, Fatma; Sayin, Elvan; Gul, Fethi; Pazar, Nazli; Culha, Gulcan; Yildiz, Serap Suzuk; Cinel, Ismail; Korten, VolkanBackground: We report a nosocomial outbreak caused by Burkholderia cepacia that occurred among six patients admitted in the medical and surgical intensive care unit between 04 March 2019 and 02 April 2019 in Istanbul, Turkey. Methods: The outbreak investigation was launched on 11 March 2019 five days after the detection of B. cepacia in four different patients. We defined potential reservoirs and started environmental screening. We sampled the liquid solutions used in patient care activities. Pulse-field gel electrophoresis (PFGE) was performed to determine the genetic relatedness of environmental and patient samples. Results: Burkholderia cepacia was isolated in tracheal aspiration cultures of six patients. Three out of six patients developed healthcare-associated pneumoniae due to B. cepacia. Environmental cultures in the ICUs revealed B. cepacia growth in 2% chlorhexidine-gluconate mouthwash solution that been used in the colonized patients as well as in samples obtained from the unused products. PFGE revealed the patient and a specific batch of chlorhexidine mouthwash solution samples had a 96% similarity. Conclusion: Contamination of medical solutions used in critical patient care could cause outbreaks and should be detected early by infection control teams.Publication Metadata only Kandan izole edilen çok ilaca dirençli escherichia coli, klebsiella pneumoniae ve pseudomonas aeruginosa kökenlerinde meropenem-vaborbaktamın etkinliğinin diğer Antibiyotiklerle karşılaştırmalı olarak araştırılması: çok merkezli çalışma(2022-11-16) GÜNEŞER, DENİZ; HASDEMİR GÖKBOĞA, MÜNEVVER UFUK; KORTEN, VOLKAN; ALTINKANAT GELMEZ, GÜLŞEN; Altınkanat Gelmez G., Güneşer D., Hasdemir Gökboğa M. U. , Korten V., Sağıroğlu P., Hazırolan G., Gür D., Öktem İ. M. A. , Aygün G.Publication Open Access Frequency and associated factors for carbapenem-non-susceptible Bacteroides fragilis group bacteria colonization in hospitalized patients: Case control study in a university hospital in Turkey(ELSEVIER, 2021-10) ÖZAYDIN, AYŞE NİLÜFER; Toprak, Nurver Ulger; Akgul, Oncu; Bilgin, Huseyin; Ozaydin, Ayse Nilufer; Gelmez, Gulsen Altinkanat; Sayin, Elvan; Sili, Uluhan; Korten, Volkan; Soyletir, GunerPurpuse: The carbapenem-resistant Bacteroides fragilis group (CR-BFG) bacteria have been reported in several countries recently with increasing global attention. The high incidence of CR-BFG isolated from our hospitalized patients has become an important problem. Therefore, we aimed to determine the frequency and associated factors for intestinal colonization by carbapenem-non-susceptible BFG (CNS-BFG) among adult patients hospitalized at intensive care units, neurosurgery and internal medicine wards in our hospital. Methods: Rectal swabs (n = 1200), collected from 766 patients between February 2014 and March 2015, were inoculated onto kanamycin-vancomycin-leaked blood agar containing 0.125 mg/L meropenem. The isolates were identified by MALDI-TOF MS. Susceptibility testing was performed by agar dilution method. The carbapenemase gene (cfiA) was detected by PCR. Logistic regression analysis was used to evaluate the associated factors for intestinal colonization by CNS-BFG. Results: A total 180 non-duplicate BFG isolates were obtained from 164 patients. Ten different species, including Parabacteroides distasonis (n = 46, 25.6%), and Bacteroides fragilis (n = 30; 16.6%), were identified. Twenty- five percent of the isolates were non-susceptible to meropenem (MIC >2 mg/L). The highest prevalence of meropenem resistant strains (MIC >8 mg/L) was detected among B. fragilis (n = 12), followed by Parabacteroides spp. (n = 4). All but one B. fragilis strains were cfiA gene positive. Hospital admission, increasing Charlson score, use of antibiotics; including carbapenems in past three months, colonization with other accompanying carbapenem-resistant Gram negative bacteria (Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa), and having undergone surgical operations were significantly associated with RCS- BFG colonization. Conclusions: The high carriage rate of CNS-BFG in hospitalized patients may lead to worse clinical outcomes, such as serious infections and mortality, and deserves attention.Publication Open Access Determination of fosfomycin susceptibility in carbapenemase-producing K. pneumoniae strains isolated prior to clinical use of the intravenous formulation in Turkey(MARMARA UNIV, FAC MEDICINE, 2021-05-25) ERTÜRK ŞENGEL, BUKET; Altinkanat Gelmez, Gulsen; Can, Baris; Erturk Sengel, Buket; Korten, Volkan; Soyletir, GunerObjectives: The incidence of infections caused by carbapenem-resistant Enterobacteriaceae has increased worldwide. Limitations in the development of new antimicrobial agents have led clinicians to reconsider the clinical efficiency of old antibiotics, such as intravenous formulation of fosfomycin, in the treatment of multidrug-resistant Gram-negative bacterial infections. We investigated the fosfomycin susceptibility of carbapenemase-producing Klebsiella pneurnoniae strains isolated prior to the clinical use of the intraveno US formulation of fosfomycin in Turkey. Materials and Methods: A total of the 155 K. pneurnoniae isolates which previously characterized at the molecular level for their carbapenemase were included in this study. The minimum inhibitory concentration of fosfomycin was determined by the agar dilution method. Results: Overall, 65.1% of the isolates were susceptible to fosfom ycin. The MIC50 and MIC90 values were 32 and 256 mg/L, respectively. According to our results, at least two-third of carbapenemase-positive K. pneumoniae are susceptible to fosfomycin. Conclusions: Although, the susceptibility of fosfomycin, which has just been put into the clinical use of intravenous formulation in Turkey, is not very high, it can be considered as an alternative adjunct antimicrobial for the treatment of systemic infections caused by carbapenentase-positive K. pneumoniae isolates.Publication Metadata only Kandan İzole Edilen Çok İlaca Dirençli Escherichia Coli, Klebsiella Pneumoniae ve Pseudomonas Aeruginosa Kökenlerinde Meropenem-Vaborbaktamın Etkinliğinin Diğer Antibiyotiklerle Karşılaştırmalı Olarak Araştırılması: Çok Merkezli Çalışma(2022-12-01) ALTINKANAT GELMEZ, GÜLŞEN; GÜNEŞER, DENİZ; HASDEMİR GÖKBOĞA, MÜNEVVER UFUK; KORTEN, VOLKAN; ALTINKANAT GELMEZ G., GÜNEŞER D., HASDEMİR GÖKBOĞA M. U., KORTEN V., SAĞIROĞLU P., HAZIROLAN G., GÜR D., ÖKTEM İ. M. A., AYGÜN G.