Person: KORTEN, VOLKAN
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
KORTEN
First Name
VOLKAN
Name
12 results
Search Results
Now showing 1 - 10 of 12
Publication Metadata only COVID-19 tanısı ile antikoagulasyon altında gelişeninfekte retroperitoneal hematom(2021-05-26) ERTÜRK ŞENGEL, BUKET; KORTEN, VOLKAN; Marku M., ERTÜRK ŞENGEL B., Çolak G. M. , KORTEN V.Amaç C.auris sağlık bakımı ilişkili infeksiyonlara neden olan, birçok antifungale dirençli son derece virülan bir mantardır. Sağlık merkezlerinde salgınlara neden olduğundan erken tanı konulması gerekli önlemlerin alınması bakımından çok önemlidir. Ancak standart laboratuvar teknikleri ile tanımlanması zordur ve spesifik yöntemler kullanılmazsa yanlış tanımlanabilir. Bu yazı COVID-19 tanısı ile yoğun bakımında yatmakta olan hastalarda nadir ve infeksiyon kontrol açısından büyük risk oluşturan C.auris üremelerini anlatmaktadır. Olgular Hastaların demografik ve klinik özellikleri Tablo 1’de özetlenmiştir. Tüm hastaların 60 yaşın üzerinde olması, öncesinde geniş spektrumlu antibiyotik ve steroid kullanım öyküleri olması dikkat çekmektedir. İntrakranial kanama nedeniyle opere edilen Olgu 1’in yara yeri ve Olgu 2’nin ise genital bölge sürüntüsünde C.auris üremesi olmuştur ve etken olarak kabul edilmemişlerdir. Olgu 5’in ise inguinal bölge sürüntü kültürlerinin yanı sıra periferik kan ve idrar kateter kültürlerinde de üreme olduğundan etken olarak kabul edilmiştir. Hastalara ait klinik örneklerden üretilmiş maya kolonileri MALDI-TOF MS (VITEK MS, V3.0, BioMérieux) kullanılarak % 99.9 identifikasyon skoru oranlarıyla C.auris olarak tanımlanmıştır. Olgu 4 halen yatmakta olup diğer tüm hastalar kaybedilmiştir. Sonuç Ülkemizde şimdiye kadar C.auris ile infekte olgu raporlanmamıştır. C. auris üremeleri, COVID-19 nedeniyle yoğun bakım yatışlarının uzaması, COVID-19 seyrinde kullanılan immunsupresif tedaviler ve geniş spektrumlu antibiyotik kullanımları gibi faktörlere bağlı olabilir. Etkenin doğru tanınması ve tedavinin erken başlanması mortalite açısından çok önemlidir. Olgularımız hem COVID-19 hastalarında hem de Türkiye’de bildirilen ilk C.auris vakaları olması nedeniyle dikkat çekici özellik taşımaktadır.Publication Metadata only Prevalence of HIV-associated neurocognitive disorder (HAND) in Turkey and assessment of Addenbrooke's Cognitive Examination Revised (ACE-R) test as a screening tool(WILEY, 2021) TİGEN, ELİF; Korten, V; Ay, U.; Hari, E.; Tigen Tukenmez, E.; Gencer, S.; Akca Kalem, S.; Demirtas Tatlidede, A.; Gurvit, I. H.Objectives We aimed to assess the Addenbrooke's Cognitive Examination Revised (ACE-R) and three questions (3Qs, European Aids Clinical Society Guidelines) as potential screening tools for HIV-associated neurocognitive disorder (HAND). In addition, we tried to determine the prevalence and associated factors for HAND among people living with HIV (PLWH) in Turkey. Methods Persons living with HIV were enrolled from two teaching hospitals between March 2018 and September 2018. Participants underwent screening tools, a neuropsychological test battery (NTB) and an assessment of activities of daily living. HAND was diagnosed according to Frascati's criteria and applying the Global Deficit Score (GDS) approach. A receiver operating characteristic (ROC) curve analysis was performed to compare the predictive accuracy of ACE-R to that of the NP test battery. Factors associated with HAND were evaluated using multivariate logistic regression analysis. Results The study sample included 162 participants (94% male). The HAND prevalence was 45.7% [asymptomatic neurocognitive impairment (ANI), 37.7%; mild neurocognitive disorder (MND), 7.4%; HIV-associated dementia (HAD), 0.6%] according to the Frascati criteria and 31.5% (ANI, 25.9%; MND, 4.9%; HAD, 0.6%) using the GDS. In the ROC analysis, the ACE-R showed an area under the curve of 0.68 at a cut-off score of 89. The sensitivity, specificity and correct classification rate of screening tests for HAND diagnosis were as follows: ACE-R (62.2%, 67%, 64.8%) and 3Qs (10.8%, 88.6%, 53%). In multivariate analysis, only education level (adjusted odds ratio [aOR] = 0.84, 95% CI: 0.76-0.92,P <= 0.001) was an independent risk factor for HAND. Conclusions HAND is a common comorbidity in PLWH in Turkey. The sensitivities and specificities of 3Qs and the ACE-R as screening tools are lower than desired.Publication Metadata only Kandan izole edilen çok ilaca dirençli escherichia coli, klebsiella pneumoniae ve pseudomonas aeruginosa kökenlerinde meropenem-vaborbaktamın etkinliğinin diğer Antibiyotiklerle karşılaştırmalı olarak araştırılması: çok merkezli çalışma(2022-11-16) GÜNEŞER, DENİZ; HASDEMİR GÖKBOĞA, MÜNEVVER UFUK; KORTEN, VOLKAN; ALTINKANAT GELMEZ, GÜLŞEN; Altınkanat Gelmez G., Güneşer D., Hasdemir Gökboğa M. U. , Korten V., Sağıroğlu P., Hazırolan G., Gür D., Öktem İ. M. A. , Aygün G.Publication Metadata only Rectal colonization with multidrug-resistant gram-negative bacteria in patients with hematological malignancies: a prospective study(TAYLOR & FRANCIS LTD, 2020) TİGEN, ELİF; Komurcu, Burak; Tukenmez Tigen, Elif; Toptas, Tayfur; Firatli Tuglular, Tulin; Korten, VolkanObjectives To investigate the risk factors for rectal colonization with carbapenem-resistantEnterobacteriaceae(CRE) and extended-spectrum ss-lactamase-producingEnterobacteriaceae(ESBL-E) in hematological malignant patients with febrile neutropenia (FN); rate of rectal colonization and infection/colonization with CRE and ESBL-E; whether empirical treatment can be revised. Methods Adult patients receiving chemotherapy were included. Rectal swab cultures of patients were screened for CRE and ESBL-E using selective chromogenic agars. Results Fifty-seven FN episodes of 57 patients were studied. Rectal colonization rates were 40.4% (23/57) and 8.8% (5/57) for ESBL-E and CRE, respectively. ESBL-E bacteremia was diagnosed in 2 (8.6%) ESBL-E colonized patients, while CRE bacteremia was detected in 1 (20%) CRE colonized patient. Amikacin (100%) and carbapenem (93%) were the most effective antibiotics against gram-negative enteric bacteria. Beta-lactam usage within the last 3 months was a significant risk factor for ESBL-E colonization. Conclusions For the treatment of FN patients either colonized with ESBL-E or having significant risk factors for ESBL-E infection, aminoglycoside containing combinations may become an alternative to carbapenems due to their high sensitivity rates. When CRE colonized hematological cancer patients develop FN or if they are hemodynamically unstable, CRE covering empiric antibiotherapy should be preferred due to high mortality rates of CRE bacteremia.Publication Metadata only C. auris outbreak in COVID-19 intensive care unit(2022-04-26) ERTÜRK ŞENGEL, BUKET; TİGEN, ELİF; ODABAŞI, ZEKAVER; KORTEN, VOLKAN; ERTÜRK ŞENGEL B., TİGEN E., SAYIN E., SEVDALİYEVA A., ÇERİKÇİOĞLU N., CİNEL İ., KORTEN V., ODABAŞI Z.Publication Metadata only Prevalence of cardiovascular disease (cvd) and comparison of risk category predictions of systemic coronary risk evaluation 2 (score2) and four other cvd risk calculators among plwhiv in Turkey(2022-10-01) TİGEN, ELİF; KORTEN, VOLKAN; TİGEN E., Gokengin D., Ozdemir H. O. , Akalin H., Kaya B., Deveci A., Inan A., Inan D., Altunsoy A., Ozel A., et al.Publication Metadata only Ventricular and atrial functions assessed byspeckle-trackingechocardiography in patients with human immunodeficiency virus(WILEY, 2021) ÇİNÇİN, AHMET ALTUĞ; Cincin, Altug; Ozben, Beste; Tukenmez Tigen, Elif; Sunbul, Murat; Sayar, Nurten; Gurel, Emre; Tigen, Kursat; Korten, VolkanPurpose Antiretroviral therapy (ART) has dramatically changed the clinical manifestation of human immunodeficiency virus (HIV) associated cardiomyopathy from severe left ventricular (LV) systolic dysfunction to a pattern of subclinical cardiac dysfunction. The aim of this study was to evaluate by speckle tracking echocardiography (STE) LV, right ventricular (RV), and biatrial functions in HIV-infected patients under different ART combinations. Methods We consecutively included 128 HIV-infected patients (mean age 44.2 +/- 10.1 years, 110 males) and 100 controls (mean age 42.1 +/- 9.4 years, 83 males). Ventricular and atrial functions were assessed by both conventional and STE. Results Although there was not any significant difference in conventional echocardiographic variables, HIV-infected patients had significantly lower LV global longitudinal strain (GLS), RV GLS, left atrial (LA) reservoir and conduit strain, and right atrial conduit strain. HIV patients receiving integrase strand transfer inhibitors and protease inhibitors (PI) had significantly lower LV GLS and LA conduit strain, while patients receiving non-nucleoside reverse transcriptase inhibitors and PI had significantly lower RV GLS than controls. CD4 count at the time of echocardiography was strongly correlated with LV GLS (r= .619,P< .001) and RV GLS (r = .606,P< .001). Conclusion Biventricular and atrial functions are subclinically impaired in HIV-infected patients. ART regimen may also affect myocardial functions.Publication Metadata only Peptoniphilus grossensis, varibaculum cambriense isolated from polymicrobial anaerobic brain abscess of a mentally retarded young patient(2022-07-31) ÜLGER, NURVER; ERTÜRK ŞENGEL, BUKET; KORTEN, VOLKAN; BAYRAKLI, FATİH; ÜLGER N., SAYIN E., BOZAN T., ERTÜRK ŞENGEL B., KORTEN V., BAYRAKLI F.Publication Metadata only Clinical Pharmacist-Led Medication Review in Hospitalized Confirmed or Probable Patients with COVID-19 During the First Wave of COVID-19 Pandemic(2024-01-01) ÜNDER, DUYGU; ENVER, CÜNEYD; DEMİRCİ, MUHAMMED YASİR; AYHAN, YUNUS EMRE; ÖZGAN, BETÜL; İLERLER, ENES EMİR; OKUYAN, BETÜL; ERTÜRK ŞENGEL, BUKET; KOCAKAYA, DERYA; SİLİ, ULUHAN; TİGEN, ELİF; KARAKURT, SAİT; KORTEN, VOLKAN; SANCAR, MESUT; ÜNDER D., ENVER C., DEMİRCİ M. Y., AYHAN Y. E., ÖZGAN B., İLERLER E. E., OKUYAN B., ERTÜRK ŞENGEL B., KOCAKAYA D., SİLİ U., et al.Objectives: Drug-related problems (DRPs) result in serious problems among hospitalized patients, high rates of morbidity and mortality, and increased healthcare costs. This study aimed to identify DRPs by clinical pharmacist-led medication review in hospitalized probable patients with coronavirus disease-2019 (COVID-19) during the first wave of the COVID-19 pandemic. Materials and Methods: This retrospective cross-sectional study was conducted at the COVID-19 inpatient services of a tertiary university hospital in Türkiye for 3 months (between March 2020 and June 2020) and included hospitalized confirmed or probable COVID-19 patients. The World Health Organization and Turkish Ministry of Health Guidelines case definitions were used to define confirmed and probable COVID-19 patients. Six clinical pharmacy residents provided medication review services during their education and training. DRPs were classified based on the Pharmaceutical Care Network Europe V9.00. The physician’s acceptance rate of clinical pharmacists’ recommendations was assessed. Results: Among 202 hospitalized patients with probable or confirmed COVID-19, 132 (65.3%) had at least one drug-related problem. Two hundred and sixty-four DRPs were identified. Drug selection (85.6%) and dose selection (9.2%) were the most common causes of these problems. Among the 80 clinical pharmacist interventions, 48.8% were accepted by the physicians. Conclusion: Clinical pharmacists identified a significant number of DRPs during the COVID-19 pandemic, particularly those related to drug interactions and drug safety, such as adverse drug reactions. This study highlights the importance of detecting and responding to DRPs in the COVID-19 pandemic.Publication Metadata only Kandan İzole Edilen Çok İlaca Dirençli Escherichia Coli, Klebsiella Pneumoniae ve Pseudomonas Aeruginosa Kökenlerinde Meropenem-Vaborbaktamın Etkinliğinin Diğer Antibiyotiklerle Karşılaştırmalı Olarak Araştırılması: Çok Merkezli Çalışma(2022-12-01) ALTINKANAT GELMEZ, GÜLŞEN; GÜNEŞER, DENİZ; HASDEMİR GÖKBOĞA, MÜNEVVER UFUK; KORTEN, VOLKAN; ALTINKANAT GELMEZ G., GÜNEŞER D., HASDEMİR GÖKBOĞA M. U., KORTEN V., SAĞIROĞLU P., HAZIROLAN G., GÜR D., ÖKTEM İ. M. A., AYGÜN G.