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EREN, FATİH

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FATİH

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20202
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Author: GÜNDÜZ, FEYZA × Has files: true ×

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    PublicationOpen Access
    Evaluation of the Association between Programmed Cell Death-1 Gene Polymorphisms and Hepatocellular Carcinoma Susceptibility in Turkish Subjects. A Pilot Study
    (MEDICAL UNIV PRESS, 2020-10-27) EREN, FATİH; Demirci, Abdullah Fatih; Demirtas, Coskun Ozer; Eren, Fatih; Yilmaz, Demet; Keklikkiran, Caglayan; Ozdogan, Osman Cavit; Gunduz, Feyza
    Background & Aims: Programmed cell death-1 (PD-1) has a vital role in regulating T-cell function, and immune escape mechanism of cancer cells. It was shown that there could be a relationship between single nucleotide polymorphisms (SNPs) in the PD-I gene and susceptibility to hepatocellular carcinoma (MCC) based on various studies. We aimed to investigate the role of three SNPs within the PD-1 gene in susceptibility to HCC in the Turkish population. Methods: Single nucleotide polymorphisms of PD-1.1, 1.5, and 1.6 were genotyped by using TaqMan Allelic Discrimination Assays in blood samples of 137 HCC and 136 control subjects, matched for age and gender. The genotype, allele and haplotype frequencies were compared in HCC and control groups using logistic regression analysis. Results: Genotype distributions of PD-1.1, PD-1.5 and PD-1.6 SNPs were in Hardy-Weinberg equilibrium. No significant difference was observed in the genotype distribution of PD-I.1, PD-1.5 and PD-1.6 polymorphisms among gender and age-matched HCC (M/F: 96/41; mean age: 61.4 +/- 11.7 years) and control group (M/F: 94/42; mean age: 61.4 +/- 10.1). In the haplotype analysis of P1)-1.1/PD-1.5/PD-1.6, no significant difference was found among HCC and control group adjusted for sex and age (all p values>0.1). Conclusion: Our findings, firstly reporting the association of PD-1.5 polymorphism with I ICC, and PD-I.1 and PD-1.6 with HCC in the Turkish population, suggest that PD-1 polymorphisms are not predisposing factors for HCC development. Future studies with larger sample sizes and different ethnic populations are required to validate our findings.
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    PublicationOpen Access
    Effect of carbon dioxide versus room air insufflation on post-colonoscopic pain: A prospective, randomized, controlled study
    (AVES, 2020-10-30) AKDENİZ, ESRA; Gunduz, Feyza; Kani, Haluk Tarik; Chang, Shannon; Akdeniz, Esra; Eren, Fatih; Yilmaz, Yusuf; Alahdab, Yesim Ozen
    Background/Aims: Room air (RA) and carbon dioxide (CO) are widely used to insatiate the colon to examine the mucosa in colonoscopy. Pain, discomfort, and bloating can be seen during and after colonoscopy secondary to bowel distention. This study aimed to investigate the effect of CO2 on post-procedure pain sensation (PPPS) in comparison with RA. Materials and Methods: Patients were randomly assigned to the RA and CO2 insufflation groups in a 1:1 ratio. The visual analog scale (VAS) was used to measure the pain before and after the colonoscopy. VAS score of 0 was accepted as the absence of pain and above 0 was accepted as the presence of pain. The primary outcome was to investigate the effect of CO2 insufflation on PPPS. Secondary outcomes were to investigate the other contributing factors affecting PPPS and the effect of CO2 on PPPS in patients with inflammatory bowel disease (IBD). Results: A total of 204 patients were enrolled in the study. No significant difference in PPPS was seen between the 2 groups at any point in time after the colonoscopy. Furthermore, there was no significant difference in pain sensation between the CO2 and RA groups in patients with IBD. When we investigated the other contributing factors to pain sensation, body-mass index (BMI) was found to be significant at 30 minutes and BMI and colonoscopy time were found to be significant at 6 hours afterwards. Conclusion: We found no favorable effect of CO2 insufflation on PPPS in colonoscopy, including in patients with IBD.