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ÇELEBİLER, ÖZHAN BEKİR

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ÇELEBİLER

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ÖZHAN BEKİR

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Now showing 1 - 8 of 8
  • Publication
    Repair of critical size defects using bioactive glass seeded with adipose-derived mesenchymal stem cells
    (WILEY, 2017) YILMAZ, BETÜL; Sacak, Bulent; Certel, Furkan; Akdeniz, Zeynep D.; Karademir, Betul; Ercan, Feriha; Ozkan, Naziye; Akpinar, Ihsan Nuri; Celebiler, Ozhan
    Bioactive glass has been demonstrated as a biocompatible bone substitute. However bone healing process can be prolonged due to late resorption of the material. Adipose derived stem cells (ASC) have osteogenic differentiation potential and hence can be a cell source for bone regeneration. The aim of this study was to test whether combination of bioactive glass with ASCs would enhance bone regeneration. Following creation of critical sized defects on the calvaria of 32 Wistar rats, the animals were randomly divided into four groups: Group C (control): Defects were left untreated; Group G: Defects were covered with autologous bone graft; Group BG: Defects were filled with bioactive glass; Group BG/ASC: Defects were filled with bioactive glass seeded with ASCs. The defect size was significantly greater in Group compared to all other groups. Bone density was significantly lower in Group C compared to Group G and Group BG/ASC. Bone regeneration score of Group C was significantly lower than other groups. Group BG/ASC demonstrated lamellar bone and havers canal formation. The results of this study demonstrated that bioactive glass implanted with ASC is a biocompatible construct stimulating radiologically and histologically evident bone regeneration similar to autologous bone grafting. (C) 2016 Wiley Periodicals, Inc.
  • PublicationOpen Access
    Evaluation of residual tumors and recurrence rates of malignant melanoma and non-melanoma skin cancer of head and neck region
    (MARMARA UNIV, FAC MEDICINE, 2019-10-31) SAÇAK, BÜLENT; Durmus Kocaaslan, Fatma Nihal; Alakus, Ali Conor; Sacak, Bulent; Celebiler, Ozhan
    Objective: In this study, we aimed to evaluate residual tumors and recurrence rates of malignant melanoma (MM) and a nonmelanoma skin cancer of (NMSC) head and neck region. Patients and Methods: Medical data of a total of 398 lesions of 323 patients who underwent surgical excision for a basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma (MM) were retrospectively analyzed. All patients were classified according to age, sex, location of the tumor, histopathological diagnosis, lesion diameter, excision diameter, surgical margin status, and residual lesions and recurrence rates. Results: There were 244 lesions (61.3%) in 189 males and 154 lesions (38.7%) in 134 females. The most common type of skin cancer was BCC in 268 lesions (67%), followed by SCC in 122 (31%), and MM in eight (2%), respectively. Recurrence was seen in 3% of the NMSC cases and in 25% of the MM cases. There was a statistically significant correlation between the histopathological diagnosis and recurrence rates. Compared to NMSC, MM cases had a higher risk for recurrence (p=0.029). Conclusion: Our study results suggest that recurrence is associated with the localization and type of the tumor, but not with the age or sex of the patient.
  • Publication
    Use of abdominal negative pressure wound therapy in different indications: a case series
    (MA HEALTHCARE LTD, 2019) EROL, BÜLENT; Kocaaslan, Fatma Nihal Durmus; Ozkan, Melekber Cavus; Akdeniz, Zeynep; Sacak, Bulent; Erol, Bulent; Yuksel, Mustafa; Celebiler, Ozhan
    Negative pressure wound therapy (NPWT) is a widely used wound management system. Several articles have been published on the advantages and complications of this system. Abdominal dressing negative pressure system (abdominal NPWT) is a newer technology, developed and used in open abdomen cases. The adherence of the sponge to the intra-abdominal organs is prevented by a polyurethane foam. This study presents a number of case series where an abdominal NPWT (ABThera, KCl, US) has been used to treat other vital organs, helping to prevent complications such as organ rupture and fatal bleeding.
  • Publication
    Cryosurgery combined with free fibular flap in the treatment of local agressive tumors: Preliminary results
    (2017-06-17) SAÇAK, BÜLENT; AKDENİZ DOĞAN, ZEYNEP DENİZ; KAYA, ZAFER; ŞENDUR, SAMET; DURMUŞ KOCAASLAN, FATMA NİHAL; ÇELEBİLER, ÖZHAN BEKİR; SAÇAK B., AKDENİZ DOĞAN Z. D., KAYA Z., ŞENDUR S., DURMUŞ KOCAASLAN F. N., ÇELEBİLER Ö. B.
  • PublicationOpen Access
    Assessment of Tissue Perfusion Following Conventional Liposuction of Perforator-Based Abdominal Flaps
    (KOREAN SOC PLASTIC & RECONSTRUCTIVE SURGERY, 2017-03-15) SAÇAK, BÜLENT; Dogan, Zeynep Deniz Akdeniz; Sacak, Bulent; Yalcin, Dogus; Pilanci, Ozgur; Tuncer, Fatma Betul; Celebiler, Ozhan
    Background The effect of liposuction on the perforators of the lower abdominal wall has been investigated in several studies. There are controversial results in the literature that have primarily demonstrated the number and patency of the perforators. The aim of this study was to determine the effect of liposuction on the perfusion of perforator-based abdominal flaps using a combined laser-Doppler spectrophotometer (O2C, Oxygen to See, LEA Medizintechnik). Methods Nine female patients undergoing classical abdominoplasty were included in the study. Perforators and the perfusion zones of the deep inferior epigastric artery flap were marked on the patient's abdominal wall. Flap perfusion was quantitatively assessed by measuring blood flow, velocity, capillary oxygen saturation, and relative amount of hemoglobin for each zone preoperatively, after tumescent solution infiltration, following elevation of the flap on a single perforator, and after deep and superficial liposuction, respectively. Results The measurements taken after elevation of the flap were not significantly different than measurements taken after the liposuction procedures. Conclusions The liposuction procedure does not significantly alter the perfusion of perforator-based abdominal flaps in the early period. The abdominal tissue discarded in a classic abdominoplasty operation can be raised as a perforator flap and has been demonstrated to be a unique model for clinical research.
  • Publication
    Implant Stability Outcomes After Immediate and Delayed Revascularized Free Fibula Flaps: A Preliminary Comparative Study
    (QUINTESSENCE PUBLISHING CO INC, 2018) SAÇAK, BÜLENT; Cabbar, Fatih; Kocaaslan, F. Nihal Durmus; Sacak, Bulent; Capar, Gonca Duygu; Celebiler, Ozhan
    Purpose: This pilot study investigated the retrospective outcomes of implants placed immediately or with a delayed protocol in revascularized free fibula flaps (FFF). Materials and Methods: Patients undergoing FFF between 2014 and 2017 were included in the study. Implants were inserted either immediately or 23.63 +/- 10.61 months after reconstructive surgery. Resonance frequency analyses were recorded at the time of implant placement (first control) and 4 months postoperatively while uncovering and screwing the gingiva formers (second control). The statistical significance level was set at P < .05. Results: Eight patients (four men, four women, mean age: 46.75 +/- 12.96 years) were included in the study. Twenty-six implants were placed in FFF (14 immediate, 12 delayed), and 28 were placed in the alveolus. All implant stability quotient (ISQ) scores were in high stability ranges. Statistically significant differences were observed between delayed (79.25 +/- 4.77) and immediate implant placement (73.14 +/- 7.42) at first controls, but not at second controls (79.17 +/- 3.59 and 76.00 +/- 6.18). The ISQ values of immediate implant placement significantly increased from first to second controls (P = .018). Bicortically placed implants showed significantly higher scores than unicortical implants (P < .05). ISQ values of FFF and alveolar bone groups were similar (P > .05). Conclusion: High stability scores similar to alveolar bone could be achieved by both immediate and delayed implant placement. Bicortical implantation results in better implant stability.
  • Publication
    An anatomical variation of the MSAP flap: Single direct cutaneous perforator in the posterior calf region
    (2017) SAÇAK, BÜLENT; Tuncer, Fatma Betul; Sacak, Bulent; Cavus Ozkan, Melekber; Celebiler, Ozhan Bekir
  • Publication
    Intraluminal fluid infusion in a rat jejunum ischemia/reperfusion model is associated with improved tissue perfusion and less mucosal damage
    (ELSEVIER SCI LTD, 2020) YILDIRIM, ALPER; Yalcin, Dogus; Sacak, Bulent; Yalcin, Muge; Yildirim, Alper; Karademir, Betul; Ercan, Feriha; Celebiler, Ozhan
    Objective: This study used an experimental model mimicking early postoperative enteral feeding after the transfer of free jejunal flap and tested the hypothesis that jejunal infusion with dextrose or saline is associated with improved tissue perfusion and/or less mucosal damage after ischemia/reperfusion (IR) injury. Methods: Thirty-five male Sprague Dawley rats were randomly divided into five groups: sham group (no IR and no intraluminal infusion); IR control group (IR but not intraluminal infusion); IR plus intraluminal 0.9% NaCl infusion or 5% dextrose or 10% dextrose infusion groups. A jejunal segment of each rat was isolated. The animals had jejunal ischemia for 40 min, reperfusion, and intestinal infusion on the basis of their allocation. Jejunal tissue perfusion was measured with laser Doppler flowmetry at one hour and two hours after reperfusion, after which the animals were sacrificed and tissue samples were obtained for the scoring of histological damage at superficial and cryptic epithelium, villus structure, and inflammatory cell infiltration and tissue nitric oxide (NO), interleukin (IL)-1, IL-6, and matrix metalloproteinase-1 (MMP) level measurements. Results: At 1 h of reperfusion, IR plus 5% dextrose and 10% dextrose groups both had significantly higher perfusion rates than the IR control group (384.8 +/- 26.7 and 462.4 +/- 44.7 versus 270.3 +/- 34.2 PU, respectively, p < 0.05 for both). These differences were maintained at 2 h of reperfusion (p < 0.05 for both). Saline infusion, however, resulted in improved tissue perfusion only at the early phase of reperfusion. Intraluminal infusion with dextrose solution, either 5% or 10%, was associated with higher tissue NO, IL-1, and IL-6 levels than that in the sham group (p < 0.05 for all). In addition, intraluminal infusion of any fluid resulted in less severe histo-logical damage (8.1 +/- 0.9 versus 5.8 +/- 1.0, 5.4 +/- 0.9, and 5.2 +/- 1.9, for IR plus saline, 5% dextrose and 10% dextrose groups, respectively, p < 0.05 for all). Conclusions: Intraluminal infusion of fluids, particularly dextrose solutions, may be protective against IR injury as demonstrated by improved tissue perfusion and less histological damage. In addition, increases in tissue NO, IL-1, and IL-6 levels in association with dextrose infusion may be explained by the activation of pro-inflammatory and anti-inflammatory protective pathways. These support early enteral feeding after free jejunum flap transfers; however, further studies are warranted. (C) 2019 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.