Person: ŞAHİN, ÖZLEM
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ŞAHİN
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ÖZLEM
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Publication Open Access The effect of COVID-19 pandemic restrictions on neovascular AMD patients treated with treat-and-extend protocol(SPRINGER, 2021-09) ÖZKAN, GAMZE; Sevik, Mehmet Orkun; Aykut, Aslan; Ozkan, Gamze; Dericioglu, Volkan; Sahin, OzlemPurpose To investigate the adherence rate of neovascular age-related macular degeneration (nAMD) patients in treat-and-extend (TAE) protocol to their anti-vascular endothelial growth factor (anti-VEGF) intravitreal injection (IVI) appointments and to evaluate the functional and anatomical outcomes of the patients who attended and did not attend their IVI appointments during the coronavirus disease 2019 (COVID-19) restriction period (RP). Methods The patients with nAMD having IVI appointments between March 16 and June 1, 2020 (RP in Turkey) were included in this retrospective study. For adherence analysis, the patients who attended (Group 1, n = 44) and who did not attend (Group 2, n = 60) their IVI appointment visits during the RP (V-RP) were evaluated according to their last visit before the RP (V-0). For outcome analysis, the patients who attend V-RP and have follow-up (Group 1a, 46 eyes) and who did not attend V-RP but later attended for follow-up (Group 2a, 33 eyes) were evaluated for functional (best-corrected visual acuity, BCVA [logMAR]) and anatomical (optical coherence tomography [OCT] disease activity) outcomes at the first visit after RP (V-1) and last visit within six months after RP (V-2). Patients received a complete ophthalmologic evaluation with anti-VEGF (Aflibercept) IVI administration at all visits. Results The adherence rate of the patients to V-RP was 42.3% (44/104). The patients in Group 1 were significantly younger (mean +/- SD years, 71.0 +/- 8.1 vs. 74.7 +/- 8.0, p = 0.024), had better median [IQR] BCVA at their first presentation (0.30 [0.54] vs. 0.61 [1.08], p = 0.023) and V-0 (0.40 [0.48] vs. 0.52 [0.70], p = 0.031), and had less hypertension (36.4% vs. 58.3%, p = 0.044) than Group 2. The mean +/- SD delay of planned IVI at V-RP in Group 2a was 13.9 +/- 6.2 weeks. Disease activity in OCT was significantly higher in Group 2a than Group 1a at V-1 (60.6% vs. 32.6%, p = 0.025). In Group 2a, the median (IQR) BCVA was significantly worse at V-1 (0.70 [0.58]) and V-2 (0.70 [0.59]) than V-0 (0.52 [0.40], p = 0.047 and p = 0.035, respectively). Conclusions More than half of the scheduled nAMD patients in TAE protocol missed their IVI visits during the RP, which resulted in a delay of their treatments. The delay of IVI treatment in those patients resulted in an increase in OCT disease activity and a decrease in BCVA.Publication Open Access A useful method for the practice of pneumatic retinopexy: Slit-lamp laser photocoagulation through the gas bubble(2023-05-01) SEVİK, MEHMET ORKUN; KUBAT, BETÜL; DERİCİOĞLU, VOLKAN; ŞAHİN, ÖZLEM; Aykut A., SEVİK M. O., KUBAT B., DERİCİOĞLU V., ŞAHİN Ö.This study aimed to demonstrate the laser retinopexy method through the gas bubble under a slit-lamp biomicroscope using a wide-field contact lens to treat rhegmatogenous retinal detachment (RRD) with pneumatic retinopexy (PR) and report its anatomical and functional results. This single-center, retrospective case series included RRD patients treated with PR using sulfur hexafluoride (SF6). The demographics, preoperative factors, and anatomical and functional outcomes were collected from the patient files. The single-procedure success rate of PR at postoperative 6th months was 70.8% (17/24 eyes), and the final success rate after secondary surgeries was 100%. The BCVA was better in the successful PR eyes at postoperative 3rd (p = 0.011) and 6th month (p = 0.016) than in failed eyes. No single preoperative factor was associated with PR success. The single-procedure success rate of PR using the laser retinopexy method through the gas bubble with a wide-field contact lens system seems comparable to the PR literature.Publication Open Access Choroidal vascularity index as an activity criterion and a treatment response measure in chronic central serous chorioretinopathy(2023-01-01) ŞAHİN, ÖZLEM; SEVİK, MEHMET ORKUN; ÇAM, FURKAN; DERİCİOĞLU, VOLKAN; SEVİK M. O., Aykut A., ÇAM F., DERİCİOĞLU V., ŞAHİN Ö.Purpose: This study aimed to evaluate the choroidal vascularity index (CVI) as an activity criterion in chronic central serous chorioretinopathy (CSC) and as a measure of treatment response after full-dose-full-fluence photodynamic therapy (fd-ff-PDT). Methods: This fellow-eye-controlled, retrospective cohort study included 23 patients with unilateral chronic CSC treated with fd-ff-PDT (6 mg/m2; 50 μcm2; 83 s). Subfoveal choroidal thickness (SFCT, μm) and CVI (%) of the affected and fellow eyes at baseline as well as at 1, 3 and 6 months after fd-ff-PDT were compared. Results: The patients\" mean age was 43.4 ± 7.3 years, and 18 (78.3%) were male. CVI was comparable between the affected and fellow eyes at baseline (66.09 ± 1.56 vs. 65.84 ± 1.57, p = 0.59). However, it became significantly lower in the affected eyes 1 (64.45 ± 1.68 vs. 65.87 ± 1.19, p = 0.002), 3 (64.21 ± 2.08 vs. 65.71 ± 1.59, p = 0.009) and 6 (64.47 ± 2.19 vs. 65.62 ± 1.52, p = 0.045) months after fd-ff-PDT. The mean SFCT and the mean CVI were significantly decreased in the affected eyes at all follow-up visits compared with baseline after fd-ff-PDT (p < 0.001). Conclusion: At baseline, CVI was comparable between affected and fellow eyes. Therefore, its use as an activity criterion in chronic CSC patients is questionable. However, it was significantly decreased in fd-ff-PDT-treated eyes, supporting its role as a measure of treatment response in chronic CSC.Publication Open Access Untitled reply(2022-07-01) SEVİK, MEHMET ORKUN; ÇAM, FURKAN; ŞAHİN, ÖZLEM; DERİCİOĞLU, VOLKAN; SEVİK M. O., ÇAM F., Aykut A., DERİCİOĞLU V., ŞAHİN Ö.