Person: ŞAHİN, ÖZLEM
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ŞAHİN
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ÖZLEM
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Publication Metadata only Resolution of cystoid macular edema with topical carbonic anhydrase inhibitor in a patient with retinal dystrophy associated with Cohen syndrome(TAYLOR & FRANCIS INC, 2021) SEVİK, MEHMET ORKUN; Sevik, Mehmet Orkun; Aykut, Aslan; Sahin, OzlemBackground: Cohen Syndrome (CS) is an autosomal recessive multisystemic disorder characterized by various ophthalmologic findings, including retinal dystrophy and associated cystoid macular edema (CME), in which there was no known effective treatment approach. Material and Methods: We describe a CS patient with a homozygous c.62 T > G, p.(Leu21*) mutation in the VPS13B gene with a topical carbonic anhydrase inhibitor (CAI; brinzolamide %1, thrice daily) responding CME. Case Description: A seven-year-old girl with an established diagnosis of CS was referred with a primary complaint of nyctalopia. On ophthalmologic examination, bilateral decreased visual acuity and normal-appearing macula with mild optic disc pallor were present. However, the detailed evaluation revealed bilateral blunted foveal reflexes, barely visible foveal pigmentation, and slightly attenuated retinal vessels without any peripheral retinal pigmentary changes in dilated fundus examination, and CME on optical coherence tomography. Bilateral topical brinzolamide thrice daily was initiated for CME. Visual acuity increased, and CME was resolved except for minimal schisis at the inner nuclear layer level at the third-month follow-up visit and remained stable up to one-year follow-up. CME reappeared after five months of self-discontinuation of the patient's therapy but resolved again with treatment resumption. Conclusion: We report the first case of CME secondary to rod-cone dystrophy associated with CS showing improvement in anatomy and visual acuity with a topical CAI.Publication Metadata only The third family with TAF6-related phenotype: Alazami-Yuan syndrome(2020) ŞAHİN, ÖZLEM; Tuc, Ecenur; Bengur, Fuat Baris; Aykut, Aslan; Sahin, Ozlem; Alanay, YaseminPublication Open Access Combined hamartoma of the retina and retinal pigment epithelium at pediatric age: surgical versus conservative approach(2022-10-10) ŞAHİN, ÖZLEM; Ozdek S., Ucgul A. Y., Hartnett M. E., Akdogan M., Sen P., Bhende M., Besirli C. G., Karacorlu M., Dedania V., Parolini B., et al.Purpose: To report outcomes of pediatric patients with combined hamartoma of the retina and the retina pigment epithelium (CHRRPE) followed up conservatively or after pars plana vitrectomy (PPV). Methods: This retrospective multicenter study included sixty-two eyes of 59 pediatric patients with CHRRPE from 13 different international centers with an average age of 7.7±4.7 (0.3-17) years at the time of the diagnosis, and having undergone PPV or followed conservatively. At baseline and each visit, visual acuity values, optical coherence tomography (OCT) for features and central foveal thickness (CFT), and tumor location were noted. Lesions were called as zone 1, if it involves the macular and peripapillary area, and the others were called as zone 2 lesions. Results: Twenty-one eyes of 20 patients in the intervention group and 41 eyes of 39 patients in the conservative group were followed for a mean of 36.2±40.4 (6-182) months. BCVA improved in 11 (68.8%) of 16 eyes in the intervention group and 4 (12.9%) of 31 eyes in the conservative group (p<0.001). The mean CFT decreased from 602.0±164.9 μm to 451.2±184.3 μm in the intervention group, while it increased from 709.5±344.2 μm to 791.0±452.1 μm in zone 1 eyes of the conservative group. Posterior location of tumor, irregular configuration of the foveal contour and ellipsoid zone defect in OCT, subretinal exudate and prominent vascular tortuosity were associated with poor visual acuity. Conclusions: Vitreoretinal surgery is safe and effective in improving vision and reducing retinal distortion in zone 1 CHRRPE in children.Publication Metadata only Pediatrik optik gliom olgularının görme keskinlikleri ile elektofizyolojik ve radyolojik bulgularının değerlendirilmesi(2022-04-23) DERİCİOĞLU, VOLKAN; EKER, NURŞAH; BUĞDAYCI, ONUR; YARGI, BERRU; KURŞUN, MELTEM; SEVİK, MEHMET ORKUN; TOKUÇ, AYŞE GÜLNUR; ŞAHİN, ÖZLEM; Dericioğlu V., Eker N., Buğdayci O., Yargi B., Kurşun M., Sevik M. O. , Tokuç A. G. , Şahin Ö.Amaç:Optik gliom nedeniyle takip edilen pediatrik hastaların en iyi düzeltilmiş görme keskinliği (EİDGK, logMAR), flaş görsel uyarılmış potansiyeller (fVEP) ve manyetik rezonans görüntüleme (MRG) sonuçlarının karşılaştırılması.Yöntem:Marmara Üniversitesi Göz Hastalıkları, Pediatrik Onkoloji ve Radyoloji bölümlerince takip edilen 22 pediatrik optik gliom hastasının 38 gözü çalışmaya dahil edildi. Hastaların başlangıç ve son takipteki EİDGK’leri, MRG’deki optik sinir kalınlıkları (OSK), kontrast tutulumları, sinyal değişimleri ve fVEP’te P2 dalgasının amplitüd ve latansları değerlendirildi.Bulgular:Hastaların yaş ortalamaları 12±5.7 yıl ve kız/erkek oranı 13/9 idi. Ortalama takip süresi 63.95±24.5 ay olarak bulundu. Gözlerin ilk ve son EİDGK’leri sırasıyla, ortanca (1.ve 3. çeyrekler aralığı) 0.2 (0-2.18) ve 0.2 (0-2.3) logMAR (p=0.586); MRG’de ölçülen ortalama OSK’leri sırasıyla, 6.51±6.03 ve 6.31±7.84 mm (p=0.650); fVEP P2 dalga ortalama amplitüdleri sırasıyla, 16.68±14.21 ve 17.93±11.96 mV (p=0.577) ve ortalama latansları sırasıyla, 149.38±50.30 ve 133.39±29.78 ms (p=0.009) olarak saptandı. Son logMAR EİDGK ile OSK (r=0.434, p=0.015), P2 amplitüdü (r=-0.432, p=0.014)) ve P2 latansı (r=0.614, p<0.001) arasında anlamlı orta düzeyde korelasyon olduğu görüldü. fVEP P2 dalga parametreleri ile OSK arasında korelasyon saptanmadı (p>0.05). P2 latansı ile MRG’de görülen sinyal (r=0.426, p=0.013) ve kontrast tutulumu (r=0.386, p=0.027) değişiklikleri arasında anlamlı korelasyon olduğu görüldü.Sonuç:Optik gliom hastalarında fVEP P2 dalga amplitüdleri ve latansları EİDGK ile ilişkili gözükmektedir. Ayrıca, P2 dalga latansının MRG’de görülen sinyal ve kontast tutulumu değişiklikleri ile de ilişkili olduğu görülmektedir. Bu bulgular, özellikle preverbal yaştaki optik gliom hastalarının değerlendirilmesinde ve hastalık ilerlemesinin takibinde fVEP’in kulanılabileceğini göstermektedir.Publication Metadata only Çocukluk çağı vitreoretinal patolojilerinde cerrahi yaklaşım(Anadolu Yayınları, 2021-01-01) ÇELİKER ATABERK, HANDE; ŞAHİN, ÖZLEM; Çeliker H., Şahin Ö.Publication Open Access The effect of COVID-19 pandemic restrictions on neovascular AMD patients treated with treat-and-extend protocol(SPRINGER, 2021-09) ÖZKAN, GAMZE; Sevik, Mehmet Orkun; Aykut, Aslan; Ozkan, Gamze; Dericioglu, Volkan; Sahin, OzlemPurpose To investigate the adherence rate of neovascular age-related macular degeneration (nAMD) patients in treat-and-extend (TAE) protocol to their anti-vascular endothelial growth factor (anti-VEGF) intravitreal injection (IVI) appointments and to evaluate the functional and anatomical outcomes of the patients who attended and did not attend their IVI appointments during the coronavirus disease 2019 (COVID-19) restriction period (RP). Methods The patients with nAMD having IVI appointments between March 16 and June 1, 2020 (RP in Turkey) were included in this retrospective study. For adherence analysis, the patients who attended (Group 1, n = 44) and who did not attend (Group 2, n = 60) their IVI appointment visits during the RP (V-RP) were evaluated according to their last visit before the RP (V-0). For outcome analysis, the patients who attend V-RP and have follow-up (Group 1a, 46 eyes) and who did not attend V-RP but later attended for follow-up (Group 2a, 33 eyes) were evaluated for functional (best-corrected visual acuity, BCVA [logMAR]) and anatomical (optical coherence tomography [OCT] disease activity) outcomes at the first visit after RP (V-1) and last visit within six months after RP (V-2). Patients received a complete ophthalmologic evaluation with anti-VEGF (Aflibercept) IVI administration at all visits. Results The adherence rate of the patients to V-RP was 42.3% (44/104). The patients in Group 1 were significantly younger (mean +/- SD years, 71.0 +/- 8.1 vs. 74.7 +/- 8.0, p = 0.024), had better median [IQR] BCVA at their first presentation (0.30 [0.54] vs. 0.61 [1.08], p = 0.023) and V-0 (0.40 [0.48] vs. 0.52 [0.70], p = 0.031), and had less hypertension (36.4% vs. 58.3%, p = 0.044) than Group 2. The mean +/- SD delay of planned IVI at V-RP in Group 2a was 13.9 +/- 6.2 weeks. Disease activity in OCT was significantly higher in Group 2a than Group 1a at V-1 (60.6% vs. 32.6%, p = 0.025). In Group 2a, the median (IQR) BCVA was significantly worse at V-1 (0.70 [0.58]) and V-2 (0.70 [0.59]) than V-0 (0.52 [0.40], p = 0.047 and p = 0.035, respectively). Conclusions More than half of the scheduled nAMD patients in TAE protocol missed their IVI visits during the RP, which resulted in a delay of their treatments. The delay of IVI treatment in those patients resulted in an increase in OCT disease activity and a decrease in BCVA.Publication Metadata only Retina hastalıklarında elektrodiagnostik testlerin kullanımı(Anadolu Yayınları, 2022-01-01) SEVİK, MEHMET ORKUN; ŞAHİN, ÖZLEM; Sevik M. O., Şahin Ö.Publication Open Access A useful method for the practice of pneumatic retinopexy: Slit-lamp laser photocoagulation through the gas bubble(2023-05-01) SEVİK, MEHMET ORKUN; KUBAT, BETÜL; DERİCİOĞLU, VOLKAN; ŞAHİN, ÖZLEM; Aykut A., SEVİK M. O., KUBAT B., DERİCİOĞLU V., ŞAHİN Ö.This study aimed to demonstrate the laser retinopexy method through the gas bubble under a slit-lamp biomicroscope using a wide-field contact lens to treat rhegmatogenous retinal detachment (RRD) with pneumatic retinopexy (PR) and report its anatomical and functional results. This single-center, retrospective case series included RRD patients treated with PR using sulfur hexafluoride (SF6). The demographics, preoperative factors, and anatomical and functional outcomes were collected from the patient files. The single-procedure success rate of PR at postoperative 6th months was 70.8% (17/24 eyes), and the final success rate after secondary surgeries was 100%. The BCVA was better in the successful PR eyes at postoperative 3rd (p = 0.011) and 6th month (p = 0.016) than in failed eyes. No single preoperative factor was associated with PR success. The single-procedure success rate of PR using the laser retinopexy method through the gas bubble with a wide-field contact lens system seems comparable to the PR literature.Publication Open Access Choroidal vascularity index as an activity criterion and a treatment response measure in chronic central serous chorioretinopathy(2023-01-01) ŞAHİN, ÖZLEM; SEVİK, MEHMET ORKUN; ÇAM, FURKAN; DERİCİOĞLU, VOLKAN; SEVİK M. O., Aykut A., ÇAM F., DERİCİOĞLU V., ŞAHİN Ö.Purpose: This study aimed to evaluate the choroidal vascularity index (CVI) as an activity criterion in chronic central serous chorioretinopathy (CSC) and as a measure of treatment response after full-dose-full-fluence photodynamic therapy (fd-ff-PDT). Methods: This fellow-eye-controlled, retrospective cohort study included 23 patients with unilateral chronic CSC treated with fd-ff-PDT (6 mg/m2; 50 μcm2; 83 s). Subfoveal choroidal thickness (SFCT, μm) and CVI (%) of the affected and fellow eyes at baseline as well as at 1, 3 and 6 months after fd-ff-PDT were compared. Results: The patients\" mean age was 43.4 ± 7.3 years, and 18 (78.3%) were male. CVI was comparable between the affected and fellow eyes at baseline (66.09 ± 1.56 vs. 65.84 ± 1.57, p = 0.59). However, it became significantly lower in the affected eyes 1 (64.45 ± 1.68 vs. 65.87 ± 1.19, p = 0.002), 3 (64.21 ± 2.08 vs. 65.71 ± 1.59, p = 0.009) and 6 (64.47 ± 2.19 vs. 65.62 ± 1.52, p = 0.045) months after fd-ff-PDT. The mean SFCT and the mean CVI were significantly decreased in the affected eyes at all follow-up visits compared with baseline after fd-ff-PDT (p < 0.001). Conclusion: At baseline, CVI was comparable between affected and fellow eyes. Therefore, its use as an activity criterion in chronic CSC patients is questionable. However, it was significantly decreased in fd-ff-PDT-treated eyes, supporting its role as a measure of treatment response in chronic CSC.Publication Open Access Staphylococcus hominis: a rare cause of endophthalmitis(2022-03-21) SEVİK, MEHMET ORKUN; ŞAHİN, ÖZLEM; Aykut A., Sevik M. O., Şan B., Şahin Ö.