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OKTAR, FAİK NÜZHET

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FAİK NÜZHET

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    Design and characterization of polycaprolactone-gelatin-graphene oxide scaffolds for drug influence on glioblastoma cells
    (PERGAMON-ELSEVIER SCIENCE LTD, 2019) ATASOY, BESTE MELEK; Unal, Semra; Arslan, Sema; Gokce, Tilbe; Atasoy, Beste Melek; Karademir, Betul; Oktar, Faik Nuzhet; Gunduz, Oguzhan
    Three-dimensional (3D) scaffolds that mimic in vivo tumor microenvironments can be used to study tumor response to anticancer treatments, since most preclinical combination treatment strategy for anti-glioma were evaluated with traditional 2D cell culture. In this research, the nanofiber scaffolds of polycaprolactone (PCL) containing gelatin (Gel) nano/microparticles coated with different concentrations of graphene oxide (GO) and were successfully produced by combining electrospinning and electrospraying techniques. Scanning electron microscope (SEM), Fourier-transform infrared (FT-IR) spectroscopy and mechanical testing were used to characterize the structure and properties of the composites. The results show that gelatin and graphene particles can be well dispersed in the polycaprolactone nanofiber matrix by using the combination technique of electrospinning and electrospraying. The presence of 1 wt% graphene oxide increased mechanical strength of PCL/Gel scaffold and was found to be well consistent with the drug treatments (temozolomide and bortezomib) and radiotherapy by not showing additional toxicity.
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    Investigation of 3D-Printed Polycaprolactone-/Polyvinylpyrrolidone-Based Constructs
    (SAGE PUBLICATIONS INC) ŞAHİN, ALİ; Izgordu, Muhammet Sefa; Uzgur, Evren Isa; Ulag, Songul; Sahin, Ali; Yilmaz, Betul Karademir; Kilic, Beyhan; Ekren, Nazmi; Oktar, Faik Nuzhet; Gunduz, Oguzhan
    The aim of this study is to evaluate the mechanical and biological performance of cartilage-like constructs produced by 3D printing. During the investigation, poly(epsilon-caprolactone) (PCL) and polyvinylpyrrolidone (PVP) were used as a matrix polymer and low-molecular-weight chitosan (CS), hyaluronic acid (HA), and alginic acid sodium salt (SA) were integrated separately with the polymer matrix to fabricate the constructs. Thermal, mechanical, morphology, and chemical properties and swelling, degradation, and biocompatibility behaviors were evaluated in detail. With the addition of 3 fillers, the melting temperature of the matrix increased with the addition of fillers, and PCL/3wt.%PVP/1wt.%HA had the highest melting temperature value. Mechanical characterization results demonstrated that the printed PCL/3wt.%PVP/1wt.%CS displayed the highest compressive strength of around 9.51 MPa. The compressive strength difference between the PCL/3wt.%PVP and PCL/3wt.%PVP/1wt.%CS was 5.38 MPa. Biocompatibility properties of the constructs were tested by mitochondrial dehydrogenase activity, and in vitro studies showed that the PCL/3wt.%PVP/1wt.%HA composite construct had more cell viability than the other constructs by making use of the mesenchymal stem cell line.
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    Nanofibrous wound dressing material by electrospinning method
    (TAYLOR & FRANCIS AS, 2019) İNAN, AHMET TALAT; Yeniay, Eda; Ocal, Leyla; Altun, Esra; Giray, Betul; Oktar, Faik Nuzhet; Inan, Ahmet Talat; Ekren, Nazmi; Kilic, Osman; Gunduz, Oguzhan
    Wound dressings are very useful materials for accelerating the wound healing process. In this study, nanofibrous wound dressings were produced from blending solution of Poly-lactic acid(PLA)/Chitosan(C)/Starch(S)/Zinc oxide(Z) by electrospinning method. Morphology, chemical interaction, mechanical, water uptake and weight loss tests were performed on each samples. Moreover, the biocompatibility of primary dermal fibroblast (ATCC, PCS-201-012) on prepared wound dressings was investigated with MTT assays in vitro, and the samples were found suitable for cell viability and proliferation. These results suggest that produced nanofibrous wound dressings can be promising candidate for wound dressing applications. [GRAPHICS] .