Person: TOKSOY ÖNER, EBRU
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TOKSOY ÖNER
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Publication Metadata only Production of the biomimetic small diameter blood vessels for cardiovascular tissue engineering(TAYLOR & FRANCIS AS, 2019) TOKSOY ÖNER, EBRU; Aydogdu, Mehmet Onur; Chou, Joshua; Altun, Esra; Ekren, Nazmi; Cakmak, Selami; Eroglu, Mehmet; Osman, Asila A.; Kutlu, Ozlem; Oner, Ebru Toksoy; Avsar, Gulben; Oktar, Faik Nuzhet; Yilmaz, Ismail; Gunduz, OguzhanA novel biomimetic vascular graft scaffolds were produced by electrospinning method with the most superior characteristics to be a proper biomimetic small diameter blood vessel using Polycaprolactone(PCL), Ethyl Cellulose(EC) and Collagen Type-1 were used to create the most convenient synergy of a natural and synthetic polymer to achieve similarity to native small diameter blood vessels. Scanning Electron Microscopy(SEM), Fourier Transform Infrared Spectroscopy(FTIR), Differential Scanning Calorimetry Analysis(DSC), tensile measurement tests, and in-vitro and in-vivo applications were performed. Results indicated significant properties such as having 39.33 nm minimum, 104.98 nm average fiber diameter, 3.2 MPa young modulus and 135% relative cell viability. [GRAPHICS] .Publication Metadata only Levan based fibrous scaffolds electrospun via co-axial and single-needle techniques for tissue engineering applications(ELSEVIER SCI LTD, 2018) TOKSOY ÖNER, EBRU; Avsar, Gulben; Agirbasli, Deniz; Agirbasli, Mehmet Ali; Gunduz, Oguzhan; Oner, Ebru ToksoyThis represents the first systematic study where levan polysaccharide was used to fabricate fibrous matrices by co-axial and single-needle electrospinning techniques. For this, hydrolyzed (hHL) and sulfated hydrolyzed (ShHL) Halomonas levan were chemically synthesized and used together with polycaprolactone (PCL) and polyethyleneoxide (PEO) for the spinning process. In co-axially spun matrices, ultimate tensile strength (UTS) were found to increase with increasing ShHL concentration and elongation at break of PCL + ShHL matrices increased up to ten-fold when compared to PCL matrices. Similarly, in single-needle spun matrices, higher elongation at break values were obtained by blending HL and ShHL with PEO pointing to the effective energy absorbing features. Dense and fine fibers were characterized by FTIR and SEM. Cell viability and fluorescence imaging of L929 fibroblasts and HUVECs as well as heparin mimetic activity of the matrices pointed to their high potential to be used in decreasing neointimal proliferation and thrombogenicity of grafts and prosthesis.Publication Metadata only Sulfated levan as a polymer for biomedical applications(ELSEVIER SCIENCE BV, 2016) TOKSOY ÖNER, EBRU; GÜNDÜZ, OĞUZHAN; Avsar, Gulben; Gunduz, Oguzhan; Oner, Ebru ToksoyPublication Metadata only Encapsulated melatonin in polycaprolactone (PCL) microparticles as a promising graft material(ELSEVIER SCIENCE BV, 2019) ÖZBEYLİ, DİLEK; Gurler, Esra Bihter; Ergul, Necdet Mekki; Ozbek, Burak; Ekren, Nazmi; Oktar, Faik Nuzhet; Haskoylu, Merve Erginer; Oner, Ebru Toksoy; Eroglu, Mehmet Sayip; Ozbeyli, Dilek; Korkut, Veysel; Temiz, Ahmet Furkan; Kocanali, Nil; Gungordu, Rosa Juvan; Kilickan, Duhan Berkan; Gunduz, OguzhanElectrospraying assures many advantages with taking less time and costing less relatively to the other conventional particle production methods. In this research, we investigated the encapsulation of melatonin (MEL) hormone in polycaprolactone (PCL) microparticles by using electrospraying method. Morphology analysis of the produced particles completed with Scanning Electron Microscopy (SEM). SEM images demonstrated that microparticles of 3 wt% PCL solution has the most suitable particle diameter size (2.3 +/- 0.64 mu m) for melatonin encapsulation. According to the characterization of the particles, electrospraying parameters like optimal collecting distance, the flow rate of the solution and voltage of the system detected as 8 cm, 0.5 ml/h, and 10 kV respectively. For determining the chemical bonds of scaffold Fourier-Transform Infrared Spectroscopy (FTIR) were used and FTIR results showed that melatonin successfully loaded into PCL micro-particles. Drug release kinetics of the melatonin loaded particles indicated that melatonin released with a burst at the beginning and release behavior became sustainable over a period of 8 h with the encapsulation efficiency of about 73%. In addition, both in-vitro and in-vivo studies of the graft materials also completed. Primary human osteoblasts (HOB) cells and female Sprague Dawley rats were used in in-vitro and in-vivo studies. Test results demonstrate cell population, and bone volume of the rats grafted with composites has remarkably increased, this caused remodelling in bone structure. Overall, these findings indicate that encapsulation of melatonin in the PCL particles with electrospray method is optimum for new synthetic graft material.Publication Metadata only Levan micro/nano particulate systems for controlled cargo delivery(2021-02-19) CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; TOKSOY ÖNER, EBRU; Cinan E., Santos S., Cesur S., Gündüz O., Mono J., Toksoy Öner E.Publication Metadata only Controlled release of resveratrol-loaded levan nanoparticles using electrospray(2021-06-26) CESUR, SÜMEYYE; GÜNDÜZ, OĞUZHAN; TOKSOY ÖNER, EBRU; Cinan E., Cesur S., Gündüz O., Toksoy Öner E.