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ÖZTÜRK, FATİH EMİN

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ÖZTÜRK

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FATİH EMİN

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2019 - 201912020 - 20222
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    PublicationOpen Access
    Prognostic Value of Tissue-Resident Memory T Cells and Tumor Microenvironmental Features in Resected Pancreatic Adenocarcinoma
    (2021) ÖZTÜRK, FATİH EMİN; Başoğlu, Tuğba; Akar, Kadriye Ebru; Bağcı, Pelin; Akgül Babacan, Nalan; Öztürk, Mehmet Akif; Öztürk, Fatih Emin; Demircan, Nazım Can; Arikan, Rukiye; Akın Telli, Tuğba; Ercelep, Özlem; Dane, Faysal; Yumuk, Perran Fulden
    BACKGROUND: Pancreatic ductal adenocarcinoma differs from other solid tumors with its unique immunosuppressive microenvironment and non-immunogenic feature. There are not many studies in the literature investigating the effect of these features on prognosis. AIM: To investigate the prognostic value of tissue-resident memory cells, tumor microenvironment features, and tumor-associated immune cells in resected pancreatic ductal adenocarcinomas. STUDY DESIGN: Retrospective cross-sectional study. METHODS: Of 138 patients diagnosed with pancreatic ductal adenocarcinoma between 2011 and 2018, 81 were included in the study. Specimens from operated patients were reassessed separately as peritumoral and intratumoral areas for tissue resident memory and tumor microenvironmental elements (tumor infiltrating lymphocytes, tumor stroma, CD204+ macrophages, PDL1+ immune cells). Disease-free survival and overall survival were defined from the date of operation to the date of recurrence and the date of first diagnosis to the date of death, respectively. If the patient was alive, the last visit date was taken into account. RESULTS: The median age at diagnosis was 63 (range: 40-78). The median follow-up period was 18.9 months (range 1.4-80.4 months). Median overall survival was 23.7 months (1.4-80.4 months) and median disease-free survival was 10.8 months (1.4-74.4 months). Patients with higher intra-tumoral tissue-resident memory cell counts had a longer survival trend than those having lower values (25.6 months vs. 18 months, respectively, P = .84). According to microenvironmental evaluations, lower stromal score (defined as stroma having less desmoplasia and rich in cells) and presence of peritumoral Crohn's-like inflammatory response were associated with higher survival (29.2 months vs. 19.7 months for low vs. high stromal scores, respectively, P = .16 and 30.2 months vs. 18.1 months for the presence of Crohn's-like inflammatory response P = .13). Decreased survival was observed in tumors with increased CD204+ tumor-associated macrophages which were immunosuppressive elements of the microenvironment (12 months vs. 26.3 months for intra-tumoral assessment, P = .29). CONCLUSION: Tissue-resident memory cells and other microenvironmental features may be prognostic in resectable pancreatic ductal adenocarcinomas. Further studies with larger cohorts are needed for validation.
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    PublicationOpen Access
    Tumor Response after Preoperative Chemoradiation Therapy with Simultaneous Integrated Boost Using Volumetric Modulated Arc Therapy in Locally Advanced Rectal Cancer
    (ELSEVIER SCIENCE INC, 2019-09) DEVRAN, BENNUR ZEYNAN; Adli, M.; Alkis, H.; Gulegen, B. Z.; Halil, S.; Degerli, A. Dagli; Ozturk, F.; Atalay, V.; Yegen, C.
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    PublicationOpen Access
    Detection of salmonella enteritidis in a immunocompetent patient with myocarditis miyokardit tanılı immünokompetan hastada salmonella enteritidis saptanması
    (2022-01-01) ÖZTÜRK, FATİH EMİN; YILDIZ, YASİN; ÖZTÜRK F. E. , YILDIZ Y., Çağlayik D. Y.
    © 2022. Turk Hijyen ve Deneysel Biyoloji Dergisi.All Rights ReservedSalmonella is a gram-negative, motile, non-sporeforming, facultative anaerobic bacterium belonging to the Enterobacteriaceae family. There are several subtypes that can cause disease in humans and animals. Infection can be caused by food, such as eggs, poultry, contaminated waters, and can also be monitored after contact with animals. In humans, it may present with different clinics ranging from asymptomatic carriage to enteric fever. Factors such as the age of the host, immunosuppressive status and additional comorbidities may be effective in the course of the disease. Extraintestinal complications can be observed during the course of enteric fever clinic. Among these complications, clinical conditions such as endocarditis, visceral abscess, osteomyelitis can be considered. In this case, we presented the myocarditis clinic in a patient who presented with vomiting, chest pain and diarrhea, and Salmonella was found in the stool