Person:
YALÇIN, AHMET SUHA

Profile Picture

Email Address

Birth Date

Research Projects

Organizational Units

OrgUnit Logo
Organizational Unit

Job Title

Last Name

YALÇIN

First Name

AHMET SUHA

Name

Filters

1990 - 19983
Reset filters

Settings

End date: 2009 × Subject: Animals ×

Search Results

Now showing 1 - 3 of 3
  • No Thumbnail Available
    PublicationMetadata only
    The functional assessment of autotransplanted splenic tissue by its capacity to remove oxidatively modified erythrocytes
    (1997) YALÇIN, AHMET SUHA; Haklar, G.; Demirel, M.; Peker, O.; Eskitürk, A.; Işgör, A.; Söyletir, G.; Yalçin, A. S.
    Free radicals and reactive oxygen species have been implicated in the pathogenesis of a variety of hematologic diseases and erythrocyte aging. Aged erythrocytes are removed from the circulation primarily by the spleen. In this study, we aimed to determine the functional effectiveness of autotransplanted splenic tissue by its capacity to remove oxidatively modified erythrocytes from the circulation. Our experimental model in rats includes splenectomy with autotransplantation of 80% of the excised splenic tissue into the omental pouch. In this model, free radical damage was estimated by different parameters of lipid peroxidation such as carbonyl content and thiobarbituric acid reactive substances (TBARS), together with Heinz body formation. Our results have shown that splenic autotransplantation was effective in removing oxidatively modified, aged erythrocytes from the circulation.
  • No Thumbnail Available
    PublicationMetadata only
    Effect of cold-restraint stress on glutathione and lipid peroxide levels in the liver and glandular stomach of rats
    (1990) YALÇIN, AHMET SUHA; Yeğen, B.; Dedeoğlu, A.; Aykaç, I.; Oktay, S.; Yalçin, A. S.
    The effect of starvation and cold-restraint stress on glutathione and lipid peroxide levels in the liver, stomach and plasma of rats was investigated. Hepatic and gastric glutathione levels were significantly decreased in starvation and cold-restraint groups when compared with values obtained from the control group. In both tissues, lipid peroxide levels were significantly decreased after starvation but were not significantly different from control values after cold-restraint treatment. However, when compared with the values obtained from the starvation group there was a significant increase in both hepatic and gastric lipid peroxide levels after cold-restraint. Plasma lipid peroxide levels were slightly decreased in the starvation group and significantly increased in the cold-restraint group. Our results suggest that pathological consequences of stress on different tissues could be due to stimulation of lipid peroxidation.
  • No Thumbnail Available
    PublicationMetadata only
    Low dose MK-801 protects against iron-induced oxidative changes in a rat model of focal epilepsy
    (1998) YALÇIN, AHMET SUHA; Küçükkaya, B.; Aker, R.; Yüksel, M.; Onat, F.; Yalçin, A. S.
    We have used chemiluminescence measurements to examine the relationship between free radical formation and excitotoxicity in a post-traumatic epilepsy model. For this purpose, seven days after injecting iron in rat brain cortices, we measured luminol- and lucigenin-enhanced chemiluminescence in different brain regions (ipsilateral cortex, contralateral cortex, hypothalamus and hippocampus). In all brain regions (except contralateral cortices) both luminol- and lucigenin-enhanced chemiluminescence were increased in iron-injected group compared to saline-injected control group. These increases returned to control values in iron-injected rats pretreated with MK-801. Our results suggest that both free radicals and excitatory amino acids play important roles in the development of post-traumatic epilepsy and that MK-801 has protective effects against iron-induced chemiluminescence formation.