Person:
YALÇIN, AHMET SUHA

Profile Picture

Email Address

Birth Date

Research Projects

Organizational Units

OrgUnit Logo
Organizational Unit

Job Title

Last Name

YALÇIN

First Name

AHMET SUHA

Name

Filters

1995 - 199912000 - 20082
Reset filters

Settings

End date: 2009 × Subject: GLUTATHIONE ×

Search Results

Now showing 1 - 3 of 3
  • No Thumbnail Available
    PublicationMetadata only
    Dietary whey supplementation in experimental models of wound healing
    (VERLAG HANS HUBER, 2008) YALÇIN, AHMET SUHA; Ogunc, Ayliz Velioglu; Manukyan, Manuk; Cingi, Asim; Eksioglu-Demiralp, Emel; Aktan, A. Odemir; Yalcin, A. Suha
    Whey is a dairy product containing milk serum proteins with diverse biological effects. In this study, the effect of dietary whey supplementation on wound healing was investigated. Rats were fed a standard or whey-supplemented diet for three weeks. Wound healing parameters, glutathione, and lipid peroxide levels were determined three days after the application of two different models of wound healing, i.e. laparotomy and colonic anastomosis. Dietary whey supplementation significantly increased glutathione levels and suppressed lipid peroxidation after experimental laparotomy and colonic anastomosis. Bursting pressures, hydroxyproline, and cytokine levels were not changed. Our results show that dietary whey supplementation increases glutathione synthesis and cellular antioxidant defense. Long-term effects of whey feeding on wound healing remains to be investigated.
  • No Thumbnail Available
    PublicationMetadata only
    PROTECTIVE EFFECTS OF CILAZAPRIL AGAINST FREE-RADICAL INJURY IN MYOCARDIAL ISCHEMIA-REPERFUSION
    (ACADEMIC PRESS (LONDON) LTD, 1995) YALÇIN, AHMET SUHA; HAKLAR, G; ERSAHIN, C; MOINI, H; SUNGUN, M; DOGAN, N; BILSEL, S; EMERK, K; YALCIN, AS
    Cilazapril is a prodrug which is rapidly hydrolysed to the pharmacologically active cilazaprilat following absorption to the bloodstream. In clinical pharmacological studies, administration of cilazapril resulted in potent, reversible, selective and competitive angiotensin converting enzyme inhibition. In this study, we have examined the protective effect of cilazapril on a myocardial ischaemia-reperfusion model by using different parameters of lipid peroxidation and protein oxidation. We have observed increased levels of diene conjugates, carbonyls and malondialdehyde as well as protein carbonyls after ischaemia-reperfusion, whereas protein sulphydryl groups were decreased. Our results clearly demonstrate that cilazapril, a non-sulphydryl, long-acting angiotensin converting enzyme inhibitor, has free-radical-scavenging potential in a model comparable to the clinical situation observed in humans.
  • No Thumbnail Available
    PublicationMetadata only
    Whey feeding suppresses the measurement of oxidative stress in experimental burn injury
    (SPRINGER, 2006) YALÇIN, AHMET SUHA; Oner, OZ; Ogunc, AV; Cingi, A; Uyar, SB; Yalcin, AS; Aktan, AO
    Purpose:Burns cause thermal injury to local tissue and trigger systemic acute inflammatory processes, which may lead to multiple distant organ dysfunction. We investigated the protective effect of dietary whey supplementation on distant organs in a rat model. Methods:Forty-eight rats were divided into six groups of eight: groups 1 and 2 were the controls, fed a standard diet and a whey-supplemented diet, respectively; groups 3 and 4 were fed a standard diet and subjected to burn injury; and groups 5 and 6 were fed a whey-supplemented diet and subjected to burn injury. We measured the oxidative stress variables, as well as glutathione in the liver and kidney, and histologically examined skin samples obtained 4h (groups 3 and 5) and 72h (groups 4 and 6) after burn injury. Results:Glutathione (GSH) levels remained the same in the liver but were slightly elevated in the kidneys after burn injury in the rats fed a standard diet. Whey supplementation caused a significant increase in hepatic GSH levels 4h after burn injury. Moreover, there was a significant rebound effect in the liver and kidney GSH levels after 72h and whey supplementation potentiated this effect. Hepatic and renal lipid peroxide levels were also increased 4h after burn injury in the rats fed a standard diet. Whey supplementation significantly suppressed the burn-induced increase in hepatic and renal lipid peroxide levels. Histological examination revealed that although whey supplementation resulted in decreased subepidermal inflammation, the indicators of wound healing and collagen deposition were not improved. Conclusion:Whey pretreatment suppressed hepatic and renal oxidative stress measurements after experimental burn injury.