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YALÇIN, AHMET SUHA

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YALÇIN

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AHMET SUHA

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1994 - 199912000 - 20062
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End date: 2019 × Subject: CELLS ×

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    EFFECT OF ANTIEPILEPTIC DRUGS ON ERYTHROCYTE OSMOTIC FRAGILITY AND LIPID-PEROXIDATION
    (ELSEVIER SCIENCE BV, 1994) YALÇIN, AHMET SUHA; YALCIN, AD; ONARAN, I; YALCIN, AS
    Epileptic children receiving antiepileptics were studied to investigate the effect of carbamazepine and phenobarbital therapy on erythrocyte osmotic fragility and lipid peroxidation. Significant differences between the two groups were observed in erythrocyte osmotic fragility. In addition, there was a significant increase in erythrocyte malondialdehyde release in the epileptic group compared to controls. It is suggested that the use of antioxidants in addition to antiepileptic drugs may be beneficial.
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    The role of reactive oxygen species and apoptosis in the pathogenesis of varicocele in a rat model and efficiency of vitamin E treatment
    (WILEY, 2004) YALÇIN, AHMET SUHA; Cam, K; Simsek, F; Yuksel, M; Turker, L; Haklar, G; Yalcin, S; Akdas, A
    We investigated role of reactive oxygen species (ROS) and apoptosis in the pathogenesis of infertility in experimental model of varicocele. The protective effect of vitamin E was also examined. Three groups of rats were constructed as the first group had sham operation, experimental varicoceles were established by partial ligation of the left renal vein in later two groups. Third group had received vitamin E. Production of ROS was determined by chemiluminescence assay (CL). The in situ end labelling technique was utilized to investigate apoptosis. Tissue vitamin E levels were measured by high performance liquid chromatography. The differences between luminol enhanced CL levels of groups were not statistically significant. However, the difference between CL levels of lucigenin probe in left testicles of sham and varicocele groups were statistically significant (p = 0.0007). Similarly, the results of the third group receiving vitamin E significantly differed from the varicocele group (p = 0.0025). The difference of apoptotic index was also statistically significant between sham and varicocele groups (p = 0.0038). Although the values of apoptotic index detected in the vitamin E group were lower compared with the varicocele group, the difference was not significant. This study proposes that ROS production and apoptosis in the testicles were induced with experimental varicocele. Vitamin E had a protective role. An increased rate of apoptosis with experimental varicocele suggests a molecular alteration, which may involve ROS overproduction as the triggering mechanism. Consequently, this study indicates an association between varicocele and infertility at molecular level through stimulation of ROS and apoptosis.
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    Whey feeding suppresses the measurement of oxidative stress in experimental burn injury
    (SPRINGER, 2006) YALÇIN, AHMET SUHA; Oner, OZ; Ogunc, AV; Cingi, A; Uyar, SB; Yalcin, AS; Aktan, AO
    Purpose:Burns cause thermal injury to local tissue and trigger systemic acute inflammatory processes, which may lead to multiple distant organ dysfunction. We investigated the protective effect of dietary whey supplementation on distant organs in a rat model. Methods:Forty-eight rats were divided into six groups of eight: groups 1 and 2 were the controls, fed a standard diet and a whey-supplemented diet, respectively; groups 3 and 4 were fed a standard diet and subjected to burn injury; and groups 5 and 6 were fed a whey-supplemented diet and subjected to burn injury. We measured the oxidative stress variables, as well as glutathione in the liver and kidney, and histologically examined skin samples obtained 4h (groups 3 and 5) and 72h (groups 4 and 6) after burn injury. Results:Glutathione (GSH) levels remained the same in the liver but were slightly elevated in the kidneys after burn injury in the rats fed a standard diet. Whey supplementation caused a significant increase in hepatic GSH levels 4h after burn injury. Moreover, there was a significant rebound effect in the liver and kidney GSH levels after 72h and whey supplementation potentiated this effect. Hepatic and renal lipid peroxide levels were also increased 4h after burn injury in the rats fed a standard diet. Whey supplementation significantly suppressed the burn-induced increase in hepatic and renal lipid peroxide levels. Histological examination revealed that although whey supplementation resulted in decreased subepidermal inflammation, the indicators of wound healing and collagen deposition were not improved. Conclusion:Whey pretreatment suppressed hepatic and renal oxidative stress measurements after experimental burn injury.