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YALÇIN, AHMET SUHA

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YALÇIN

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AHMET SUHA

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2006 - 200912010 - 20152
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Start date: 2002 × Subject: EXPRESSION ×

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    Whey Protein Versus Whey Protein Hydrolyzate for the Protection of Azoxymethane and Dextran Sodium Sulfate Induced Colonic Tumors in Rats
    (SPRINGER, 2012) YALÇIN, AHMET SUHA; Attaallah, Wafi; Yilmaz, Ayse Mine; Erdogan, Nusret; Yalcin, A. Suha; Aktan, A. Ozdemir
    Recent studies have shown that whey protein has many useful effects including its anti-cancer effect. In this study we have compared the protective effect of dietary whey protein with whey protein hydrolyzate against azoxymethane and dextran sodium sulfate induced colon cancer in rats. We used a rat model of the colon cancer induced by administration of azoxymethane followed by repeated dextran sodium sulfate ingestion which causes multiple tumor development. Colon tissues were analyzed histologically in addition to biochemical analyses performed by measuring lipid peroxidation, protein oxidation and glutathione levels in both of colon and liver tissues of rats after sacrification. Macroscopic and microscopic tumors were identified in all groups that received azoxymethane followed by repeated dextran sodium sulfate. Group fed with whey protein hydrolyzate showed significantly less macroscopic and microscopic tumor development compared with group fed with whey protein. The protocol applied to generate an appropriate model of colon cancer was successful. Whey protein hydrolyzate was found to be more effective in preventing colon tumor development compared with whey protein.
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    Whey feeding suppresses the measurement of oxidative stress in experimental burn injury
    (SPRINGER, 2006) YALÇIN, AHMET SUHA; Oner, OZ; Ogunc, AV; Cingi, A; Uyar, SB; Yalcin, AS; Aktan, AO
    Purpose:Burns cause thermal injury to local tissue and trigger systemic acute inflammatory processes, which may lead to multiple distant organ dysfunction. We investigated the protective effect of dietary whey supplementation on distant organs in a rat model. Methods:Forty-eight rats were divided into six groups of eight: groups 1 and 2 were the controls, fed a standard diet and a whey-supplemented diet, respectively; groups 3 and 4 were fed a standard diet and subjected to burn injury; and groups 5 and 6 were fed a whey-supplemented diet and subjected to burn injury. We measured the oxidative stress variables, as well as glutathione in the liver and kidney, and histologically examined skin samples obtained 4h (groups 3 and 5) and 72h (groups 4 and 6) after burn injury. Results:Glutathione (GSH) levels remained the same in the liver but were slightly elevated in the kidneys after burn injury in the rats fed a standard diet. Whey supplementation caused a significant increase in hepatic GSH levels 4h after burn injury. Moreover, there was a significant rebound effect in the liver and kidney GSH levels after 72h and whey supplementation potentiated this effect. Hepatic and renal lipid peroxide levels were also increased 4h after burn injury in the rats fed a standard diet. Whey supplementation significantly suppressed the burn-induced increase in hepatic and renal lipid peroxide levels. Histological examination revealed that although whey supplementation resulted in decreased subepidermal inflammation, the indicators of wound healing and collagen deposition were not improved. Conclusion:Whey pretreatment suppressed hepatic and renal oxidative stress measurements after experimental burn injury.
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    Synergistic Effects of Methotrexate and Suberoylanilide Hydroxamic Acid in Triggering Apoptosis of Chronic Myeloid Leukemia Cells
    (AKAD DOKTORLAR YAYINEVI, 2015-03-30) YALÇIN, AHMET SUHA; Altundag, Ergul M.; Yilmaz, Ayse M.; Corek, Ceyda; Yalcin, A. Suha; Taga, Yavuz; Kocturk, Semra
    In this study, we have investigated the effects of suberoylanilide hydroxamic acid (SAHA) against chronic myeloid leukemia (CML) cells in combination studies with methotrexate (MTX), which is a dihydrofolate reductase inhibitor used in combination therapy with other agents or alone. Combination of synergistic ratios of MTX and SAHA led to apoptotic cell death of CML cells via PARR cleavage, cytochrome c release and ROS increase in vitro. We suggest that combination of MD( and SAHA may minimize the toxicity and side effects of SAHA treatment, thus providing lower amounts of each drug in CML treatment.