Person: YILMAZ, BETÜL
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YILMAZ
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BETÜL
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Publication Metadata only Repair of critical size defects using bioactive glass seeded with adipose-derived mesenchymal stem cells(2016-05-25) AKDENİZ DOĞAN, ZEYNEP DENİZ; SAÇAK, BÜLENT; YILMAZ, BETÜL; ERCAN, FERİHA; AKDENİZ DOĞAN Z. D., SAÇAK B., YILMAZ B., ERCAN F., ÇELEBİLER Ö. B.Publication Metadata only Hypercholesterolemia Mediated Endoplasmic Reticulum Stress Response Might Be Related to Autophagic Death of Cardiomyocytes in Heart Failure(ELSEVIER SCIENCE INC, 2016) YILMAZ, BETÜL; Ozer, Nesrin Kartal; Sozen, A. Erdi; Yazgan, Burak; Karademir, BetulPublication Metadata only Repair of critical size defects using bioactive glass seeded with adipose-derived mesenchymal stem cells(WILEY, 2017) YILMAZ, BETÜL; Sacak, Bulent; Certel, Furkan; Akdeniz, Zeynep D.; Karademir, Betul; Ercan, Feriha; Ozkan, Naziye; Akpinar, Ihsan Nuri; Celebiler, OzhanBioactive glass has been demonstrated as a biocompatible bone substitute. However bone healing process can be prolonged due to late resorption of the material. Adipose derived stem cells (ASC) have osteogenic differentiation potential and hence can be a cell source for bone regeneration. The aim of this study was to test whether combination of bioactive glass with ASCs would enhance bone regeneration. Following creation of critical sized defects on the calvaria of 32 Wistar rats, the animals were randomly divided into four groups: Group C (control): Defects were left untreated; Group G: Defects were covered with autologous bone graft; Group BG: Defects were filled with bioactive glass; Group BG/ASC: Defects were filled with bioactive glass seeded with ASCs. The defect size was significantly greater in Group compared to all other groups. Bone density was significantly lower in Group C compared to Group G and Group BG/ASC. Bone regeneration score of Group C was significantly lower than other groups. Group BG/ASC demonstrated lamellar bone and havers canal formation. The results of this study demonstrated that bioactive glass implanted with ASC is a biocompatible construct stimulating radiologically and histologically evident bone regeneration similar to autologous bone grafting. (C) 2016 Wiley Periodicals, Inc.Publication Metadata only Combination of proteasome inhibitors with temozolomide to increase the anti-tumor effect in 3D culture model of glioblastoma(ELSEVIER SCIENCE INC, 2018) YILMAZ GÖLER, AYŞE MİNE; Unal, Semra; Gokce, Tilbe; Arslan, Sema; Yilmaz, Ayse Mine; Gunduz, Oguzhan; Karademir, BetulPublication Metadata only Cathepsins D and L reduce the toxicity of advanced glycation end products(ELSEVIER SCIENCE INC, 2012) YILMAZ, BETÜL; Grimm, Stefanie; Horlacher, Melanie; Catalgol, Betul; Hoehn, Annika; Reinheckel, Thomas; Grune, TilmanAdvanced glycation end product-modified proteins are known for accumulating during aging and in several pathological conditions such as diabetes, renal failure, and neurodegenerative disorders. There is little information about the intracellular fate of endocytosed advanced glycation end products (AGES) and their influence on proteolytic systems. However, it is known that the lysosomal system is impaired during aging. Therefore, undegraded material may accumulate and play a considerable role in the development of diverse diseases. To investigate if AGEs can be degraded and to test whether they accumulate because of impaired lysosomal proteases we studied the effects of advanced glycation end products on the endosomal lysosomal system. Five different types of AGEs were generated by bovine serum albumin incubation with glyoxal, methylglyoxal, glucose, fructose, and ribose. The first experiments revealed the uptake of AGEs by the macrophage cell line RAW 264.7. Further investigations demonstrated an increase in cathepsin D and L activity and an increase in mature cathepsins D and L Increased activities were accompanied by the presence of more lysosomes, measured by staining with LysoTracker blue. To specify the roles of cathepsins D and L we used knockout cells to test the roles of both cathepsins on the toxicity of advanced glycation end products. In summary we conclude that both cathepsins are required for a reduction in advanced glycation end product-induced cytotoxicity. (C) 2012 Elsevier Inc. All rights reserved.Publication Metadata only ER stress related lipid accumulation and apoptotic cell death in nonalcoholic fatty liver diesease(ELSEVIER SCIENCE INC, 2017) ŞAHİN, ALİ; Demirel, Tugce; Sozen, Erdi; Sahin, Ali; Karademir, Betul; Ozer, Nesrin KartalPublication Metadata only Redox Regulation and Cancer Therapy(BENTHAM SCIENCE PUBL LTD, 2018) YALÇIN, AHMET SUHA; Yalcin, A. Suha; Karademir, BetulPublication Metadata only Heat shock proteins and proteasomal degradation in normal and tumor cells(ELSEVIER SCIENCE INC, 2014) YILMAZ, BETÜL; Betul, Karademir; Perinur, Bozaykut; Nesrin, Kartal OzerPublication Metadata only The proteasomal system as a target in cancer therapy(ELSEVIER SCIENCE INC, 2016) YILMAZ, BETÜL; Karademir, BetulPublication Metadata only Cellular Protection and Therapeutic Potential of Tocotrienols(BENTHAM SCIENCE PUBL LTD, 2011) YILMAZ, BETÜL; Catalgol, Betul; Batirel, Saime; Ozer, Nesrin KartalTocotrienols, components belonging to vitamin E members, are used as potent therapeutics in the treatment of several diseases. Recent studies suggested tocotrienol to have better activity in many situations compared to tocopherols. Tocotrienols have been shown to lower the atherogenic apolipoprotein B and lipoprotein plasma levels. Additionally, tocotrienols with their anti-tumor effect together with anti-angiogenic and anti-thrombotic effects may serve as effective agents in cancer therapy. Besides these effects, some properties such as water insolubility and low stability limit the usage of tocotrienols in the clinic. However recent studies tried to increase the bioavailability with esterification and combination use. These efforts for the clinical usage of tocotrienols which may help them to take a wide place in the clinic and additional studies are needed to identify their therapeutical mechanisms.