Person: BATIREL, SAİME
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BATIREL
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SAİME
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Publication Metadata only Theophylline-loaded pectin-based hydrogels. I. Effect of medium pH and preparation conditions on drug release profile(WILEY, 2018) BATIREL, SAİME; Guner, Ozde Zeynep; Cam, Cansu; Arabacioglu-Kocaaga, Banu; Batirel, Saime; Guner, F. SenihaIn this study, a series of theophylline-loaded calcium pectin gel films were prepared in three different Ca+2 concentrations with three different methods for wound dressing applications. Drug release performance of the films were investigated in four different medium pH in order to mimic wound healing pH conditions. Hydrogel films were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, scanning electron microscopy and atomic force microscopy. Their absorbency (fluid handling), swelling behavior, dehydration rate, dispersion characteristic, dressing pH determination, water vapor permeability, oxygen permeability, surface contact angle, flexibility, Shore A hardness, mean mass per unit area and thickness were determined. The effect of the hydrogels on wound healing was evaluated with an in vitro wound healing assay. After evaluating all data, we suggested that the hydrogel film prepared with swelling method using 7% or 10% crosslinker and dried at 26 degrees C is more suitable for controlled drug release process. We showed that between pH 3.25 and 7.12 the form of the hydrogel did not change, and drug release was continuous. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46731.Publication Metadata only Dual effect of procaine-loaded pectin hydrogels: pain management and in vitro wound healing(SPRINGER, 2021) BATIREL, SAİME; Rodoplu, Seniz; Celik, Bengi Ezgi; Kocaaga, Banu; Ozturk, Cenk; Batirel, Saime; Turan, Deniz; Guner, F. SenihaThis study aims to develop procaine-loaded pectin hydrogels for both local anesthetic delivery and wound healing. We investigated the effects of initial drug concentration, pH of initial drug solution, and drying temperature of hydrogel on the drug release behavior of hydrogels. Fourier transform infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy were used for their characterization. Their swelling percentage, drug loading, and drug release behaviors were determined. Toxic effects of selected hydrogels on the wound healing ability of PCS-201-012 human dermal fibroblast cells and wound dressing properties were also investigated. According to our results, the hydrogels did not affect cell migration. Initial drug concentration, pH of initial drug solution, and drying temperature of hydrogels are crucial on procaine release behavior of pectin-based hydrogels.Publication Metadata only Low-methoxyl pectin-zeolite hydrogels controlling drug release promote in vitro wound healing(WILEY, 2019) BATIREL, SAİME; Kocaaga, Banu; Kurkcuoglu, Ozge; Tatlier, Melkon; Batirel, Saime; Guner, F. SenihaThis study presents the design of novel hydrogel films, based on low-methoxyl (LM) pectin and NaA- or ZnA-zeolite particles, to serve as wound dressing materials with controlled drug delivery properties. We studied the effects of the preparation method of hydrogels, the amounts of crosslinker, drug and zeolite, and the type of cation in zeolites on the drug release mechanisms from the hydrogels. Ionic strengths of both film and external medium dictated the drug release behavior of the films, while the other parameters also played essential roles. NaA-zeolite hydrogels prepared using membrane diffusion controlled system, could reach a drug release ratio of 86% within 5 h. The drug-free hydrogels displayed no cytotoxicity while supporting cell proliferation and migration. Our cost-effective LM pectin-zeolite hydrogels promise to be effective wound dressing materials with controlled drug delivery ability, transparency, good swelling properties, ability to hold fluids, good oxygen transmission rate, and biocompatibility. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47640.