Person: CİNEL, ZELİHA LEYLA
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CİNEL
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ZELİHA LEYLA
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Publication Open Access Nodular mucinosis of the breast: A rare entity(MARMARA UNIV, FAC MEDICINE, 2018-06-05) SALMAN, ANDAÇ; Salman, Andac; Cinel, Leyla; Turkoz, Huseyin Kemal; Akbas, Gamze; Ergun, TulinNodular mucinosis of the breast (NMB) is an uncommon disease involving the nipple-areolar region. It usually presents with asymptomatic, subcutaneous masses with indolent growth in women. Here, we report a 43-year-old man presented with a subcutaneous growth on the left nipple. Histopathological examination confirmed the diagnosis of NMB. We report our patient in order to point out this rare disease and think that the recognition of this entity is important for both clinicians and pathologists.Publication Open Access An unusual presentation of ocular rosacea(CONSEL BRASIL OFTALMOLOGIA, 2017) ÇELİKER ATABERK, HANDE; Celiker, Hande; Toker, Ebru; Ergun, Tulin; Cinel, LeylaRosacea is a chronic, progressive disease of unknown cause affecting the eye and the facial skin. Ocular rosacea is often underdiagnosed if the ophthalmologist does not inspect the patient's face adequately during the ocular examination. Severe ocular complications and blindness can occur if the treatment is delayed because of non-diagnosis of the rosacea. Here, we present a case of ocular rosacea in a 78-year-old Caucasian woman. Based on the ocular lesions, which preceded cutaneous involvement, she was misdiagnosed as having ocular cicatricial pemphigoid initially. This case emphasizes the difficulty in diagnosis when ocular findings precede those of skin manifestations, and rosacea should be kept in mind in the differential diagnosis of chronic cicatrizing conjunctivitis.Publication Open Access Adenoid ‘ameloblastoma: Clinicopathological description of 4 additional BRAF-negative cases(2023-12-01) CİNEL, ZELİHA LEYLA; Khalaj F., CİNEL Z. L., Aminishakib P., Mosavat F., SOLUK TEKKEŞİN M.Objective: Adenoid ameloblastoma (AA) is an epithelial odontogenic tumor that was recognized as a separate entity in the last odontogenic classification of WHO in 2022. The etiology is unknown, and the pathogenesis remains controversial. The objective of this study is to contribute the clinicopathological features of 4 additional BRAF-negative cases to the existing literature, aiming to enhance the molecular understanding of this unique tumor in the forthcoming classification. Materials and methods: This study consists of a case series of four patients diagnosed with AA. The patients’ demographic and clinical information were collected from the universities’ medical achieves. Histopathologically, all cases were reexamined according to the latest update of the WHO odontogenic tumor classification. In addition to H&E and immunohistochemical stains, cytogenetics was also evaluated. Results: Well-defined unilocular radiolucent lesions were observed in all cases. Ameloblastoma-like components exhibited reserved nuclear polarity, suprabasal stellate reticulum-like epithelium, duct-like structure, whorls/morules, and cribriform architecture were common features. Variable immunoreactivity to CK7, CK19, CK14, p63, and p40 were determined, and proliferative activity was greater than 15%. The BRAF molecular study revealed no mutations. Conclusions: When diagnosing AA, the essential histopathological characteristics must be rigorously applied, and a significant portion of the lesion should contain these features. Additionally, despite limited molecular data, since the BRAF mutation commonly observed in ameloblastomas is not present in the majority of AA cases, we propose changing the term \"ameloblastoma\" to \"ameloblastic\" and referring to it as \"adenoid ameloblastic tumor\" in the forthcoming classification.Publication Open Access The promising role of Gelsolin expression to predict survival in patients with squamous cell carcinoma of the larynx(2021-06) BATMAN, ABDULLAH ÇAĞLAR; Şahin, Akın; Enver, Necati; Erçetin, Selim Yiğit; Cinel, Zeliha Leyla; Batman, Abdullah ÇağlarPublication Open Access Primary Cutaneous Adenoid Cystic Carcinoma(2020) KESKİN ÖZTÜRK, BEYZA; Caner KAYA;F. Nihal DURMUŞ KOCAASLAN;Zeliha Leyla CİNEL;Beyza KESKİN;Özhan ÇELEBİLERAdenoid cystic carcinoma is a malignant tumor usually localized in the salivary glands. It can also develop in serous glands such as the breast, main bronchi, uterine cervix, Bartholin's gland of the vulva, prostate gland, and external auditory canal. It is more common in the white race. Most of the primary cutaneous adenoid cystic carcinoma cases occur on the scalp. Despite the high rate of metastasis, long-term survival can be observed because the progression of the disease is slow. Distant organ metastases such as lungs, bone, liver and brain have also been reported in the literature at 40%. Its treatment is wide excision of the lesion and demonstration of tumor negative margin in pathological sampling. In this case report, we wanted to present surgical and oncological treatment to a 65-year-old female patient with lung metastasis diagnosed with adenoid cystic carcinoma on the scalp.Publication Open Access Interobserver agreement among histological patterns and diagnosis in lung adenocarcinomas(2013) AHISKALI, ASİYE RENGİN; Urer, Halide Nur; Ahiskali, Rengin; Arda, Naciye; Batur, Sebnem; Cinel, Leyla; Dekan, Gerhard; Fener, Neslihan; Firat, Pinar; Geleff, Silvana; Oz, Buge; Ozluk, Yasemin; Yildiz, Kursat; Yilmazbayhan, Emine Dilek; Zeren, Handan; Uysal, AtillaPublication Open Access Clinicopathological features of trichoblastomas and malignant variant: trichoblastic carcinoma(MARMARA UNIV, FAC MEDICINE, 2021-05-26) CİNEL, ZELİHA LEYLA; Ozkan, Melekber Cavus; Cinel, Zeliha LeylaObjective: Trichoblastomas are rare benign tumors of the skin appendages with epithelial and mesenchyntal components that exhibit differentiation to the follicular germinative epithelium and particularly to the follicular stroma of the skin. Our aim was to contribute to already limited literature data in order to gain more insights into the treatment and follow-up of patients with this condition. Methods and Materials: A total of 9 patients with trichoblastoma and 1 patient with malignant trichoblastoma were surgically treated between 2016 and 2020 at the Department of Plastic, Reconstructive and Aesthetic Surgery, School of Medicine, Marmara University. Results: Of the 10 patients with trichoblastoma, 5 were female and 5 were male, with a median age of 49 years. The smallest and largest lesion lenghts were 0.4 and 2 cm, respectively. Seven lesions had developed in the head and neck region, while 2 were in the trunk One of our cases was a 45-year old female patient with a malignant trichoblastoma presented with a lesion in the right side of the lower lip. Conclusion: Trichoblastomas are rare tumors that affect both sexes equally and are seen most commonly in the head and neck region. Recurrence rates were found to be low when they were treated with negative surgical margins.Publication Open Access Unilateral cutaneous vasculitis: An uncommon presentation and a possible explanation(MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2015) SALMAN, ANDAÇ; Tekin, Burak; Salman, Andac; Tuglular, Serhan; Guler, Derya; Ozen, Gulsen; Direskeneil, Haner; Ayranci, Fatma Guicicek; Cinel, Leyla; Ergun, TullnPublication Open Access Severe allergic dysregulation due to a gain of function mutation in the transcription factor STAT6(2023-01-01) BARIŞ, SAFA; YÜCELTEN, AYŞE DENİZ; BOZKURTLAR, EMİNE; CİNEL, ZELİHA LEYLA; AYDINER, ELİF; ÖZEN, AHMET OĞUZHAN; BARIŞ S., Benamar M., Chen Q., Catak M. C., Martínez-Blanco M., Wang M., Fong J., Massaad M. J., Sefer A. P., Kara A., et al.Background: Inborn errors of immunity have been implicated in causing immune dysregulation, including allergic diseases. STAT6 is a key regulator of allergic responses. Objectives: This study sought to characterize a novel gain-of-function STAT6 mutation identified in a child with severe allergic manifestations. Methods: Whole-exome and targeted gene sequencing, lymphocyte characterization, and molecular and functional analyses of mutated STAT6 were performed. Results: This study reports a child with a missense mutation in the DNA binding domain of STAT6 (c.1114G>A, p.E372K) who presented with severe atopic dermatitis, eosinophilia, and elevated IgE. Naive lymphocytes from the affected patient displayed increased TH2- and suppressed TH1- and TH17-cell responses. The mutation augmented both basal and cytokine-induced STAT6 phosphorylation without affecting dephosphorylation kinetics. Treatment with the Janus kinase 1/2 inhibitor ruxolitinib reversed STAT6 hyperresponsiveness to IL-4, normalized TH1 and TH17 cells, suppressed the eosinophilia, and improved the patient\"s atopic dermatitis. Conclusions: This study identified a novel inborn error of immunity due to a STAT6 gain-of-function mutation that gave rise to severe allergic dysregulation. Janus kinase inhibitor therapy could represent an effective targeted treatment for this disorder.Publication Open Access Evaluation of LRIG1 expression in larynx pathologies(2022-03-01) CİNEL, ZELİHA LEYLA; YUMUŞAKHUYLU, ALİ CEMAL; Gündoğdu Y., Asya O., Gönen A., Muradov T., Erçetin S. Y., Cinel Z. L., Yumuşakhuylu A. C.Objective: Studies have been performed on many biomolecules to determine the prognosis of LSCC and predict the course of the disease. However, a molecular marker that can be used clinically has not yet been found. Therefore, in this study, we aimed to investigate the expression levels of LRIG 1 in laryngeal cancer. Materials and Methods: In our study, 219 cases who underwent surgery due to LSCC and 88 randomly selected patients whose pathologic result were benign and premalignant lesions in Marmara University Pendik Education and Research Hospital between 2003 and 2018 were analyzed. Patients’ data were obtained from the medical records. The tissue microarray method was used to evaluate specimens. Results: There was a statistically significant difference between the tumor differentiation, diagnosis, and the expression of LRIG1 (respectively p=0.045, p<0.001). Also, an increase in the degree of dysplasia in premalignant lesions correlates with a decrease in LRIG1 expression (p=0.015). Conclusion: Our findings suggest that LRIG1 plays a role in the early tumorigenesis of LSCC. Therefore, LRIG1 can be a target molecule for treatment approaches. However, LRIG1 was not correlated with overall survival of the LSCC.