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EKREN, NAZMİ

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2018 - 20203
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Author: KILIÇ, OSMAN × Subject: FABRICATION ×

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Now showing 1 - 3 of 3
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    Preparation and characterization of electrospun polylactic acid/sodium alginate/orange oyster shell composite nanofiber for biomedical application
    (SPRINGER, 2020) BİLĞİÇ ALKAYA, DİLEK; Cesur, Sumeyye; Oktar, Faik Nuzhet; Ekren, Nazmi; Kilic, Osman; Alkaya, Dilek Bilgic; Seyhan, Serap Ayaz; Ege, Zeynep Ruya; Lin, Chi-Chang; Erdem, Serap; Erdemir, Gokce; Gunduz, Oguzhan
    Bone tissue engineering has begun to draw attention in recent years. The interactive combination of biomaterials and cells is part of bone tissue engineering. Sodium alginate (SA) is a biologically compatible, degradable, non-toxic natural polymer accepted by the human body and is widely used in the field of tissue engineering. Polylactic acid (PLA) is another type of biodegradable thermoplastic polyester derived from renewable sources which are used in bone tissue engineering and biomedical owing to its biocompatibility and biodegradability. Hydroxyapatite (HA) and tricalcium phosphate (TCP) derived from natural sources such as marine species and bovine bone are biocompatible and non-toxic biomaterials which are used to reconstruct many parts of the skeleton. In this study, PLA, SA with different compositions, and nanofibers obtained by adding orange spiny oyster shell powders (Spondylus barbatus) to them by using electrospining technique. Cell culture study, scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and physical analysis such as density, electrical conductivity, surface tension, viscosity measurement, and tensile strength measurement tests were carried out after the production process. Produced nanofibers showed smooth and beadless surface. The average diameters and distributions decreased with the addition of optimum PLA and TCP amount. The tensile strength of nanofibers was enhanced with the additional SA and TCP. The produced nanofibers are compatible with human bone tissue, which are not cytotoxic, and in addition, a high cell efficiency of SaOS-2 cells on the nanofibers was observed with SEM images.
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    Novel electrospun polycaprolactone/graphene oxide/Fe3O4 nanocomposites for biomedical applications
    (ELSEVIER SCIENCE BV, 2018) OKTAR, FAİK NÜZHET; Aydogdu, Mehmet Onur; Ekren, Nazmi; Suleymanoglu, Mediha; Erdem-Kuruca, Serap; Lin, Chi-Chang; Bulbul, Ertugrul; Erdol, Meltem Nur; Oktar, Faik Nuzhet; Terzi, Umit Kemalettin; Kilic, Osman; Gunduz, Oguzhan
    In this study, one of the most promising methods of tailoring a composite scaffold material in nano sized diameters, electrospinning method were used to produce Polycaprolactone (PCL)/Graphene Oxide (GO)/Iron(II, III) Oxide (Fe3O4) nanocomposite fibers as biocompatible scaffolds for biomedical applications. Products were analyzed by scanning electron microscopy (SEM) for morphological analysis of the electrospun nanocomposites and Fourier Transform Infrared Spectroscopy (FTIR) was used to determine functional groups of the PCL, GO, and Fe3O4 materials in the electrospun nanocomposites. For physical properties, viscosity, density, permittivity, dielectric loss and liquid and solid state alternating current conductivity, measurements were done for each nanocomposite fibers. Effects of concentration percentage of GO on permittivity, dielectric loss and AC conductivity have been analyzed by using measured and calculated data. Trend lines have been drawn for permittivity, dielectric loss and conductivity via concentration percentage of GO. The relation between ac conductivity and frequency have been studied for each concentration percentage of GO and interpretations have been done by using the obtained results.
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    Nanofibrous wound dressing material by electrospinning method
    (TAYLOR & FRANCIS AS, 2019) İNAN, AHMET TALAT; Yeniay, Eda; Ocal, Leyla; Altun, Esra; Giray, Betul; Oktar, Faik Nuzhet; Inan, Ahmet Talat; Ekren, Nazmi; Kilic, Osman; Gunduz, Oguzhan
    Wound dressings are very useful materials for accelerating the wound healing process. In this study, nanofibrous wound dressings were produced from blending solution of Poly-lactic acid(PLA)/Chitosan(C)/Starch(S)/Zinc oxide(Z) by electrospinning method. Morphology, chemical interaction, mechanical, water uptake and weight loss tests were performed on each samples. Moreover, the biocompatibility of primary dermal fibroblast (ATCC, PCS-201-012) on prepared wound dressings was investigated with MTT assays in vitro, and the samples were found suitable for cell viability and proliferation. These results suggest that produced nanofibrous wound dressings can be promising candidate for wound dressing applications. [GRAPHICS] .