Person: ATICI, ALİ EMRE
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
ATICI
First Name
ALİ EMRE
Name
13 results
Search Results
Now showing 1 - 10 of 13
Publication Metadata only Pankreati̇koduodenektomi̇ sonrasi yapilan uç yan pankreti̇kojejenostomi̇lerde stent uygulamasi pankreati̇k fi̇stül oranina etki̇li̇ mi̇?(2021-09-12) ATICI, ALİ EMRE; ÖZOCAK, AYŞEGÜL BAHAR; UPRAK, TEVFİK KIVILCIM; COŞKUN, MÜMİN; YEGEN, ŞEVKET CUMHUR; ATICI A. E., ÖZOCAK A. B., UPRAK T. K., COŞKUN M., YEGEN Ş. C.Publication Open Access Optimal waiting period to surgical treatment after neoadjuvant chemoradiotherapy for locally advanced rectum cancer: A retrospective observational study(2023-12-01) ATICI, ALİ EMRE; BOZKURTLAR, EMİNE; YEGEN, ŞEVKET CUMHUR; Aslanov K., ATICI A. E., Karaman D., BOZKURTLAR E., YEGEN Ş. C.Background: The optimal waiting period after neoadjuvant treatment in patients with locally advanced rectal cancers is still controversial. The literature has different results regarding the effect of waiting periods on clinical and oncological outcomes. We aimed to investigate the effects of these different waiting periods on clinical, pathological, and oncological outcomes. Methods: Between January 2014 and December 2018, a total of 139 consecutive patients with locally advanced rectal adenocarcinoma, who were treated in the Department of General Surgery at the Marmara University Pendik Training and Research Hospital, were enrolled in the study. The patients were split into three groups according to waiting time for surgery after neoadjuvant treatment: group 1 (n = 51) included patients that have 7 weeks and less (≤ 7 weeks) time interval, group 2 (n = 45) 8 to 10 weeks (8–10 weeks), group 3 (n = 43) 11 weeks and above (11 weeks ≤). Their database records, which were entered prospectively, were analyzed retrospectively. Results: There were 83 (59.7%) males and 56 (40.3%) females. The median age was 60 years, and there was no statistical difference between the groups regarding age, gender, BMI, ASA score, ECOG performance score, tumor location, and preoperative CEA values. Also, we found no significant differences regarding operation times, intraoperative bleeding, length of hospital stay, and postoperative complications. According to the Clavien–Dindo (CD) classification, severe early postoperative complications (CD 3 and above) were observed in 9 patients. The complete pathological response (pCR, ypT0N0) was observed in 21 (15.1%) patients. The groups had no significant difference regarding 3-year disease-free and 3-year overall survival (p = 0.3, p = 0.8, respectively). Local recurrence was observed in 12 of 139 (8.6%) patients and distant metastases occurred in 30 of 139 (21.5%) patients during the follow-up period. There was no significant difference between the groups in terms of both local recurrence and distant metastasis (p = 0.98, p = 0.43, respectively). Conclusion: The optimal time for postoperative complications and sphincter-preserving surgery in patients with locally advanced rectal cancer is 8–10 weeks. The different waiting periods do not affect disease-free and overall survival. While long-term waiting time does not make a difference in pathological complete response rates, it negatively affects the TME quality rate.Publication Metadata only Pankreati̇koduodenektomi̇ sonrası hei̇delberg ve blumgart pankreati̇kojejenostomi̇ anastomoz tekni̇kleri̇ni̇n karşılaştırılmasi: yüksek volümlü referans merkezi̇ sonuçları(2021-09-12) ATICI, ALİ EMRE; ÖZOCAK, AYŞEGÜL BAHAR; UPRAK, TEVFİK KIVILCIM; COŞKUN, MÜMİN; YEGEN, ŞEVKET CUMHUR; ATICI A. E., ÖZOCAK A. B., UPRAK T. K., COŞKUN M., YEGEN Ş. C.Publication Open Access Neuropeptide w alleviates hepatorenal oxidative damage in sepsis-induced rats(2020-05-01) ATICI, ALİ EMRE; PEKER EYÜBOĞLU, İREM; ERCAN, FERİHA; AKKİPRİK, MUSTAFA; YEGEN, BERRAK; ATICI A. E., ARABACI TAMER S., levent h. n., PEKER EYÜBOĞLU İ., ERCAN F., AKKİPRİK M., YEGEN B.Background: Despite modern surgical, medical and intensive care treatments, sepsis is still one of the most frequent causes of morbidity and mortality due to multiple life-threatening organ dysfunctions. We aimed to investigate the possible protective effect of neuropeptide W (NPW), a novel peptide effective in regulating neuroendocrine functions, against sepsisinduced hepatorenal damage. Methods: In male Sprague-Dawley rats (200–250 g), sepsis was induced by cecal ligation and puncture under ketamine anesthesia (n=48). Immediately after surgery, saline or TNF-alpha inhibitor (etanercept; 1 mg/kg) plus antibiotic (ceftriaxon; 100 mg/kg) (ET+C) or NPW (0.1, 0.3, 1 or 3 mg/kg) was given subcutaneously, and repeated at 12th and 24th hours, while sham-operated control group (n=8) received three saline injections within twenty-four hours. Rats were decapitated at the 25th hour of surgery and C-reactive protein (CRP), corticosterone and IL-6 levels were measured in serum samples. Kidney and liver samples were obtained for the measurement of myeloperoxidase activity (MPO), malondialdehyde and glutathione levels and nuclear factor kappa-B (NF-kB) mRNA expression levels. Histopathological evaluations were performed in hematoxylin-eosin-stained samples. ANOVA and Student's t-tests were used for data analysis. Results: Elevated serum levels of IL-6, corticosterone and CRP (p<0.05-0.01) in saline-treated sepsis group, as compared to controls, were depressed in the ET+C- (p<0.05) or NPW- (p<0.05-0.001) treated groups. Hepatic malondialdehyde and MPO levels, which were increased in salinetreated sepsis group (p<0.05 and p<0.001), were decreased by ET+C- (p<0.01) or NPW (p<0.05-0.001) treatments. Similarly, increased renal malondialdehyde level was depressed by NPW (p<0.05), but not by ET+C; while none of the treatments had an inhibitory effect on renal MPO. In contrast to replenished renal glutathione levels by all treatments, hepatic glutathione content was not changed by any of the treatments. Hepatic and renal NF-kB mRNA expressions were similar in all groups. Severe hepatocyte degeneration, sinusoidal congestion and inflammatory cell infiltration were observed in saline-treated sepsis group, while parenchymal degeneration, congestion and Kupffer cell activation were mild in ET+Cand NPW-treated sepsis groups. Similarly, severe degeneration of renal corpuscles and tubules with glomerular and interstitial congestion in the saline-treated sepsis group was replaced by moderate glomerular and interstitial vascular congestion and mild tubular congestion in both NPW- and ET+C-treated groups. Conclusion: NPW, applied during the first 24 hours of sepsis, exerted a dose-dependent protective effect against hepatorenal damage, which appears to involve an inhibitorPublication Open Access Pancreatic neuroendocrine tumor mimicking intraductal papillary mucinous neoplasm: Case report(2021-01-01) AKMERCAN, AHMET; BAĞCI ÇULÇİ, PELİN; ATICI, ALİ EMRE; YEGEN, ŞEVKET CUMHUR; UPRAK, TEVFİK KIVILCIM; AKMERCAN A., UPRAK T. K., BAĞCI ÇULÇİ P., ATICI A. E., YEGEN Ş. C.ABSTRACTPancreatic neuroendocrine tumors (PanNETs) are rare pancreatic tumors. They usually exhibit parenchymal growing, however some cases can exhibit intraductal growing. PanNET with intraductal growth may cause intraductal papillary mucinous neoplasm (IPMN)- like clinic scenario by presenting as cystic formations secondary to duct obstruction. In our case, a 69-year- old man with a history of abdominal pain and nausea underwent a computed tomography scan that showed dilated pancreatic duct and cystic lesion which was 8 cm originating from the pancreas. Imaging and laboratory findings were considered to be consistent with an IPMN so the patient underwent distal pancreatectomy and splenectomy. However, the pathological examination of the surgical specimen showed a millimeter-sized PanNET located in pancreatic tail mimicking the IPMN by obstructing the pancreatic duct.Keywords: Gastroenteropancreatic neuroendocrine tumor; pancreatic intraductal neoplasmsPublication Metadata only Üst Gastrointestinal Sistem Kaçaklarının Kendinden Genişleyen Metal Stentler (SEMS )ile tedavisi, tekmerkez sonuçlarımız(2022-04-27) COŞKUN, MÜMİN; UPRAK, TEVFİK KIVILCIM; ATICI, ALİ EMRE; COŞKUN M., Verdiyev O., UPRAK T. K., ATICI A. E.Publication Metadata only ÖZOFAGUS REZEKSİYONU SONRASI ANOSTOMOZ KAÇAĞINDAENDOSKOPİK VAKUM TEDAVİSİ DENEYİMİMİZ: 3 HASTALIK VAKA SERİSİ(2021-10-30) AKMERCAN, TAYFUN; AKMERCAN, AHMET; UPRAK, TEVFİK KIVILCIM; ATICI, ALİ EMRE; COŞKUN, MÜMİN; AKMERCAN T., AKMERCAN A., UPRAK T. K. , ATICI A. E. , COŞKUN M.Publication Metadata only Mide Kanserinde Bilgisayarlı Tomografi ile Ölçülen Kas Kütlesi Postoperatif Komplikasyon ve Sağkalımı Öngerebilir mi?(2022-04-27) AKMERCAN, AHMET; UPRAK, TEVFİK KIVILCIM; BUĞDAYCI, ONUR; ATICI, ALİ EMRE; AKMERCAN A., UPRAK T. K., BUĞDAYCI O., ATICI A. E.Publication Metadata only Sağ ve sol kolon kanserlerinde tümördepositlerinin görülme sıklığı ve onkolojiksonuçlara etkisi(2021-12-04) ATICI, ALİ EMRE; UPRAK, TEVFİK KIVILCIM; YEGEN, ŞEVKET CUMHUR; Mammadova G., ATICI A. E., UPRAK T. K., YEGEN Ş. C.Publication Metadata only Comparison of different anastomosis types in treatment of ileocecal crohn’sdisease(2022-10-01) UPRAK, TEVFİK KIVILCIM; AKMERCAN, AHMET; ATICI, ALİ EMRE; UPRAK T. K., AKMERCAN A., ERGENÇ M., SEVİNDİ H. İ., ATICI A. E.