Person: GÜNEŞ, FATMA ESRA
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GÜNEŞ
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FATMA ESRA
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Publication Metadata only Evaluation of a Standardized Bakery Product (SUTMEK) as a Potential Tool for Baked-Milk Tolerance and Immunotherapy Research Studies(KARGER, 2019) ÖZEN, AHMET OĞUZHAN; Kiykim, Ayca; Karakoc-Aydiner, Elif; Gunes, Esra; Nain, Ercan; Ogulur, Ismail; Yazici, Duygu; Aktac, Sule; Bicer, Ayse Humeyra; Sackesen, Cansin; Baris, Safa; Ozen, AhmetBackground and Objectives: About 65-80% of children with IgE-mediated cow's milk allergy (CMA) can tolerate extensively heated milk. We have invested in the mass fabrication of a test product containing milk protein baked at 180 degrees C for 30 min (SUTMEK-milk) and a milk-free placebo (SUTMEK-placebo) to carry out a standardised double-blind placebo-controlled food challenge (DBPCFC) test in patients with CMA. Methods: We studied children with IgE-mediated CMA between 13 and 48 months of age. Specific IgEs (spIgE) to milk proteins were quantified. A DBPCFC with our bakery products was performed, and factors determining reactivity to extensively heated milk were evaluated. We also tested the applicability of SUTMEK products in baked-milk oral immunotherapy in a pilot assessment. Results: We studied 15 children (8 girls, 7 boys) with a median age of 26 months (range: 13-48 months). Nine (60%) patients tolerated a challenge with extensively heated milk, while 6 (40%) were found reactive (anaphylaxis: 2, wheezing: 2, urticaria: 2). spIgE to milk, alpha-lactalbumin, and casein, and the wheal diameter on skin prick testing were higher in the reactive group than the tolerant groups (p = 0.001, p = 0.001, p = 0.002, and p = 0.048, respectively). Receiver-operating characteristic curve analyses yielded the following cut-off values for spIgEs that would predict a reactivity to extensively heated milk; milk: 25 kU/L (area under curve, AUC: 0.981), casein: 32 kU/L (AUC: 0.983), and alpha-lactalbumin: 17 kU/L (AUC: 0.981). Nine patients have tolerated well a continued daily consumption of SUTMEK-milk or -placebo for 6 months at the desired doses. Conclusions: Our bakery products were successfully used in DBPCFC studies and qualified as an acceptable tool for use in the research of interventional tolerance induction. Although spIgE appears useful in determining children at high risk of reacting to extensively heated milk, the predictive cut-off values are still far from being perfect. (c) 2018 S. Karger AG, BaselPublication Open Access Development and Validation of a Semi-Quantitative Food Frequency Questionnaire to Assess Dietary Intake of Turkish School-Aged Children(INST ANIMAL REPRODUCTION & FOOD RESEARCH POLISH ACAD SCIENCES OLSZTYN, 2016-06-30) GÜNEŞ, FATMA ESRA; Gunes, Fatma Esra; Elmaciogiu, Funda; Aktac, Sule; Saglam, DuyguThe aim of this study was to develop and validate a food frequency questionnaire (FFQ) on the dietary intake of Turkish school-aged children. Fifty randomly selected students aged 7-12 from urban areas of Istanbul were included in this study. An FFQ, containing a list of 138 frequently consumed foods was developed. Dietary records (DRs) including three days, and FFQs were collected during autumn and spring. Daily consumption of each food group was assessed and the nutrient compositions of diet were calculated. The Pearson correlation coefficient, weighted kappa, the Bland-Altman scatter plots between averages of the reported (FFQ) and the references method (DR) were used as validity coefficient. The Pearson correlation, energy adjusted and attenuation coefficients of nutrient intake were calculated for energy (0.29; 0.11), protein (0.36-0.32; 0.21), carbohydrate (0.25-0.09; 0.15), fat (0.25-0.05; 0.13), and as for food groups, for meat group (0.29-0.21, 0.09), oil and margarine groups (0.21-0.02, 0.08), dairy group (0.52-0.58, 0.31), vegetable group (0.14-0.11, 0.09), fruit group (0.31-0.40, 0.09) and cereal group (0.33-0.34, 0.10), respectively. According to the kappa values, there is moderate and fair agreement between two methods. The Bland-Altman scatter plots showed an acceptable level of agreement between the two methods that DRs may be replaced with FFQ. The performance of the FFQ is likely to allow detection and sufficient assessment of nutritional status. The developed FFQ had validity coefficients similar to those of FFQs in previous studies.Publication Metadata only Sabri Ülker Vakfı - Yemekte denge besin tüketim sıklığı ve miktarı araştırması - II sonuçları(2019-10-12) GÜNEŞ, FATMA ESRA; AKTAÇ, ŞULE; SABUNCULAR, GÜLEREN; KAMARLI ALTUN H., GÜNEŞ F. E., AKTAÇ Ş., SEREMET KÜRKLÜ N., ÖZEN S., SABUNCULAR G., SUNA G., ARCA D. M., ŞEN N., ERDİN S.Publication Metadata only IMPLEMENTATION OF A BALANCED NUTRITION EDUCATION PROGRAM AMONG PRIMARY SCHOOL CHILDREN IN TURKEY(ELSEVIER SCIENCE INC, 2018) GÜNEŞ, FATMA ESRA; Besler, Halit Tanju; Meseri, Reci; Kucukerdonmez, Ozge; Sahin, Habibe; Cicek, Betul; Gunes, Esra; Aktac, Sule; Aksoy, Burcu; Mutus, BegumPublication Metadata only Evaluation of Nutrition Knowledge of Pregnant Women before and after Nutrition Education according to Sociodemographic Characteristics(TAYLOR & FRANCIS INC, 2018) KARĞIN, DİCLE; Aktac, Sule; Sabuncular, Guleren; Kargin, Dicle; Gunes, Fatma EsraThe aim of this cross-sectional study is to evaluate the effect of nutrition education on nutritional knowledge levels of pregnant women. The study was undertaken on a sample of pregnant women (i = 743) attending health centers in Istanbul for prenatal care. Nutrition knowledge scores were significantly higher in posttest (23.0) than pretest (16.0) after receiving nutrition education (p < .001). Significant differences in pretest (p < .05) but not posttest (p > .05) scores were found for factors, such as education level, work status, and the number of pregnancies; significant differences in both test scores were found for age and nutrition information (p < .05). In conclusion, pregnant women need to be given adequate and appropriate nutrition education for maternal and child health according to sociodemographic characteristics.