Publication:
Intraoperative ultrasonography-guided surgery: An effective modality for breast conservation after neo-adjuvant chemotherapy

Simple item page
dc.contributor.authorGÜLLÜOĞLU, MAHMUT BAHADIR
dc.contributor.authorsTasdoven, Ilhan; Cakmak, Guldeniz Karadeniz; Emre, Ali Ugur; Engin, Huseyin; Bahadir, Burak; Bakkal, Hakan Bekir; Gulluoglu, Mahmut Bahadir
dc.date.accessioned2022-03-12T22:42:59Z
dc.date.available2022-03-12T22:42:59Z
dc.date.issued2020
dc.description.abstractMargin status is one of the significant prognostic factors for recurrence in breast-conserving surgery (BCS). The issue that merits consideration for oncologic safety and cost-effectiveness about the modalities to assure clear margins at initial surgical intervention remains controversial after neo-adjuvant chemotherapy (NAC). The presented study aimed to assess the impact of intraoperative ultrasound (IOUS)-guided surgery on accurate localization of tumor site, adequacy of excision with clear margins, and healthy tissue sacrifice in BCS after NAC. Patients who had IOUS-guided BCS ater NAC were reviewed. No patient had preoperative localization with wire or radiotracer. Intraoperative real-time sonographic localization, sonographic margin assessment during resection, macroscopic and sonographic examination of specimen, and cavity shavings (CS) were done as the standard procedure. No frozen assessment was performed. One hundred ninety-four patients were included, in which 42.5% had pCR. IOUS-guided surgery accomplished successful localization of the targeted lesions in all patients. Per protocol, all inked margins on CS specimens were reported to be tumor-free in permanent histopathology. No re-excision or mastectomy was required. For a setting without CS, the negative predictive value (NPV) of IOUS rate was 96%. IOUS was found to over and underestimate tumor response to NAC both in 2% of patients. IOUS-guided surgery seems to be an efficient modality to perform adequate BCS after NAC with no additional localization method. Especially, when CS is integrated as a standard to BCS, IOUS seems to provide safe surgery for patients with no false negativity and a high rate of NPV.
dc.identifier.doi10.1111/tbj.13992
dc.identifier.eissn1524-4741
dc.identifier.issn1075-122X
dc.identifier.pubmed33443786
dc.identifier.urihttps://hdl.handle.net/11424/236279
dc.identifier.wosWOS:000553701800001
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofBREAST JOURNAL
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbreast-conserving surgery
dc.subjectintraoperative ultrasonography
dc.subjectneo-adjuvant chemotherapy
dc.subjectCONSERVING SURGERY
dc.subjectCANCER PATIENTS
dc.subjectRE-EXCISION
dc.subjectPREOPERATIVE CHEMOTHERAPY
dc.subjectSURGICAL OUTCOMES
dc.subjectULTRASOUND GUIDANCE
dc.subjectSEED LOCALIZATION
dc.subjectAMERICAN SOCIETY
dc.subjectMARGIN STATUS
dc.subjectMANAGEMENT
dc.titleIntraoperative ultrasonography-guided surgery: An effective modality for breast conservation after neo-adjuvant chemotherapy
dc.typearticle
dspace.entity.typePublication
local.avesis.idd573668b-1d1b-435a-be61-105677f3ea45
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
local.journal.quartileQ3
oaire.citation.endPage1687
oaire.citation.issue9
oaire.citation.startPage1680
oaire.citation.titleBREAST JOURNAL
oaire.citation.volume26
relation.isAuthorOfPublication6d478db0-15a8-4b2b-878f-dc3d1b256022
relation.isAuthorOfPublication.latestForDiscovery6d478db0-15a8-4b2b-878f-dc3d1b256022

Files

Collections

Research Outputs