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Antimicrobial and Cytocompatible Bovine Hydroxyapatite-Alumina-Zeolite Composite Coatings Synthesized by Pulsed Laser Deposition from Low-Cost Sustainable Natural Resources

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dc.contributor.authorOKTAR, FAİK NÜZHET
dc.contributor.authorsPopescu-Pelin, Gianina; Ristoscu, Carmen; Duta, Liviu; Stan, George E.; Pasuk, Iuliana; Tite, Teddy; Stan, Miruna Silvia; Bleotu, Coralia; Popa, Marcela; Chifiriuc, Mariana C.; Oktar, Faik Nuzhet; Nicarel, Anca; Mihailescu, Ion N.
dc.date.accessioned2022-03-12T22:54:48Z
dc.date.available2022-03-12T22:54:48Z
dc.date.issued2020
dc.description.abstractBovine hydroxyapatite (BHA) and BHA blended with clinoptilolite (CLIN) and alumina (Al2O3) coatings were synthesized using pulsed laser deposition (PLD) with a KrF* excimer laser source (lambda = 248 nm, tau(FWHM) <= 25 ns). Physical-chemical characteristics and the potential use of coatings for preventing bacteria adhesion and biofilm formation were investigated. Optimized PLD conditions were selected for coatings with rough morphologies, suitable for good cell adhesion and implant anchorage and good replication of the source target composition. The crystallinity of composite coatings was progressively decreasing with the augment of the Al2O3 and CLIN contents, which in turn can facilitate an efficacious release of active components. Al2O3- and CLIN-containing coatings exhibited high cytocompatibility and specific antibiofilm profiles, preventing the initiation and maturation of bacterial biofilms. Optimum biological activity profiles associated with the use of sustainable and/or inexpensive materials are, in our opinion, of key importance for the future development of performant implant coatings, which should he perfectly compatible with the surrounding tissue while preventing postsurgical endogenous or nosocomial infections.
dc.identifier.doi10.1021/acssuschemeng.9b05031
dc.identifier.issn2168-0485
dc.identifier.urihttps://hdl.handle.net/11424/236527
dc.identifier.wosWOS:000526352300002
dc.language.isoeng
dc.publisherAMER CHEMICAL SOC
dc.relation.ispartofACS SUSTAINABLE CHEMISTRY & ENGINEERING
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectsustainable resources
dc.subjectantibacterial PLD coatings
dc.subjectbovine-origin HA
dc.subjectclinoptilolite and Al2O3 dopants
dc.subjectcytocompatibility
dc.subjectCLINOPTILOLITE
dc.subjectBONE
dc.subjectCRYSTALLIZATION
dc.subjectBIOMATERIALS
dc.subjectSPECTRA
dc.subjectAPATITE
dc.subjectIR
dc.titleAntimicrobial and Cytocompatible Bovine Hydroxyapatite-Alumina-Zeolite Composite Coatings Synthesized by Pulsed Laser Deposition from Low-Cost Sustainable Natural Resources
dc.typearticle
dspace.entity.typePublication
local.avesis.idee8e000d-3771-48a0-b3be-bf073699c62b
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages11
local.journal.quartileQ1
oaire.citation.endPage4036
oaire.citation.issue10
oaire.citation.startPage4026
oaire.citation.titleACS SUSTAINABLE CHEMISTRY & ENGINEERING
oaire.citation.volume8
relation.isAuthorOfPublication5ba0a0e0-ebae-43a6-855c-0aabb90021f4
relation.isAuthorOfPublication.latestForDiscovery5ba0a0e0-ebae-43a6-855c-0aabb90021f4

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