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Electrospun Amygdalin and Inula helenium Extract-loaded Polylactic acid (PLA)/Polyvinylpyrrolidone (PVP) Nanofibrous Patches for Colon Cancer Treatment: Fabrication, Characterization and Antitumour Effect Results

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dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorsSulutas R. B., Cesur S., Seyhan S. A., Alkaya D. B., Şahin A., Ekren N., Gunduz O.
dc.date.accessioned2024-07-31T12:18:36Z
dc.date.available2024-07-31T12:18:36Z
dc.date.issued2024-07-01
dc.description.abstractin this study, 75PLA/25PVP nanofibrous loaded with amygdalin (AMG) andInula helenium(I.H) extract were produced by electrospinning method in order to prevent local colon cancer recurrence, and the effect of the produced nanofibrous on the HCT-116cell line was examined in vitro. When the scanning electron microscopy (SEM) images were examined, the fiber diameter of the 75PLA/25PVP group was measured as 443.74±79nm, but the addition ofI.Hand AMG caused a thickening effect on the fiber diameters. Drug release results show the controlled release period of 75PLA/25PVP/I.Hand 75PLA/25PVP/AMG loaded nanofibrous patches within 180h. Slowly degrading nanofibrous remained durable for up to 25 days. When the in vitro cytotoxicity results were analyzed, all nanofibrous were found to be effective in inducing cytotoxicity against HCT-116 colon cancer cells. The most effective group is the group in whichI.Hextract and AMG drug are loaded onto the nanofibrous together. AMG drug andI.Hplant extract showed effects on the colon cancer cell line in in vitro experiments. Considering all the results I.H and AMG loaded nanofibrous can be implanted into solid tumor cells in order to reduce the risk of local recurrence of cancer after surgery in colon cancer.
dc.identifier.citationSulutas R. B., Cesur S., Seyhan S. A., Alkaya D. B., Şahin A., Ekren N., Gunduz O., "Electrospun Amygdalin and Inula helenium Extract-loaded Polylactic acid (PLA)/Polyvinylpyrrolidone (PVP) Nanofibrous Patches for Colon Cancer Treatment: Fabrication, Characterization and Antitumour Effect Results", JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, cilt.99, ss.105940, 2024
dc.identifier.doi10.1016/j.jddst.2024.105940
dc.identifier.endpage105940
dc.identifier.issn1773-2247
dc.identifier.startpage105940
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S1773224724006099
dc.identifier.urihttps://hdl.handle.net/11424/297346
dc.identifier.volume99
dc.language.isoeng
dc.relation.ispartofJOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectKlinik Tıp (MED)
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectTemel Bilimler (SCI)
dc.subjectDoğa Bilimleri Genel
dc.subjectÇOK DİSİPLİNLİ BİLİMLER
dc.subjectClinical Medicine (MED)
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectNatural Sciences (SCI)
dc.subjectNATURAL SCIENCES, GENERAL
dc.subjectMULTIDISCIPLINARY SCIENCES
dc.subjectMultidisipliner
dc.subjectMultidisciplinary
dc.subjectColon cancer
dc.subjectPlant extract
dc.subjectAmygdalin
dc.subjectNanofibrous patch
dc.subjectPLA
dc.subjectPVP
dc.titleElectrospun Amygdalin and Inula helenium Extract-loaded Polylactic acid (PLA)/Polyvinylpyrrolidone (PVP) Nanofibrous Patches for Colon Cancer Treatment: Fabrication, Characterization and Antitumour Effect Results
dc.typearticle
dspace.entity.typePublication
local.avesis.ida427cf10-41ef-4f1d-9574-94471227174d
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublication.latestForDiscoverydda71138-8ce4-4265-89b2-73bc94786a4f

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