Publication: Prognostic value of the lactate-albumin difference for predicting in-hospital mortality in critically ill patients with sepsis
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Date
2022-01-01
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Abstract
Objective: To evaluate the prognostic performance of the lactate–albumin difference (LAD), maximum lactate levels, and the
Sequential Organ Failure Assessment (SOFA) score taken on the first day in critically ill patients with sepsis, on in-hospital mortality
and 90-day survival.
Patients and Methods: Data from the Medical Information Mart for Intensive Care III (MIMIC III) version 1.4 were evaluated
retrospectively. The first day data of adult patients with sepsis diagnosed according to the Third International Consensus Definitions
for Sepsis and Septic Shock (Sepsis-3) criteria were recorded. The effectiveness of all diagnostic modalities on admission was analyzed
to predict in-hospital mortality and 90-day survival.
Results: In-hospital mortality was 20.3% among the 2270 patients included in this study. The area below the receiver operating
characteristic curve (AUC) value of the LAD was higher than lactate for predicting mortality (AUC, 0.691; 95% confidence interval
[CI], 0.663–0.718; p< 0.01, and AUC, 0.675; 95% CI, 0.646–0.703; p< 0.01, respectively), and the AUC of SOFA score was the highest
(AUC, 0.716; 95% CI, 0.663–0.718). The optimal cutoff of LAD was 0.7.
Conclusion: In addition to its easy and simple calculability relative to the SOFA, the prognostic performance of LAD was superior to
maximum lactate levels for predicting in-hospital mortality and 90-day survival in adult patients with sepsis.
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Tıp, Sağlık Bilimleri, Temel Tıp Bilimleri, Medicine, Health Sciences, Fundamental Medical Sciences, TIP, GENEL & DAHİLİ, Klinik Tıp, Klinik Tıp (MED), MEDICINE, GENERAL & INTERNAL, CLINICAL MEDICINE, Clinical Medicine (MED), Family Practice, Fundamentals and Skills, General Health Professions, Pathophysiology, Internal Medicine, Assessment and Diagnosis, Medicine (miscellaneous), General Medicine, Lactate-albumin difference, Lactate, Sepsis, In-hospital mortality, Survival, ORGAN FAILURE, Lactate-albumin difference, Lactate, Sepsis, In-hospital mortality, Surviva
Citation
Tore Altun G., Arslantas M. K., ÇORMAN DİNÇER P., Arslantas R., KARARMAZ A., "Prognostic value of the lactate-albumin difference for predicting in-hospital mortality in critically ill patients with sepsis", MARMARA MEDICAL JOURNAL, cilt.35, sa.1, ss.61-66, 2022