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Effects of aminoguanidine on lipid and protein oxidation in diabetic rat kidneys

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dc.contributor.authorYALÇIN, AHMET SUHA
dc.contributor.authorsYavuz D.G., Küçükkaya B., Ersöz H.Ö., Yalçin A.S., Emerk K., Akalin S.
dc.date.accessioned2022-03-15T08:23:13Z
dc.date.available2022-03-15T08:23:13Z
dc.date.issued2002
dc.description.abstractNonenzymatic glycation of tissue and plasma proteins may stimulate the production of oxidant and carbonyl stress in diabetes. The aim of this study was to evaluate the effects of aminoguanidine (AG) on lipid peroxidation, protein oxidation and nitric oxide (NO) release in diabetic rat kidneys. After induction of diabetes with streptozotocin, female Wistar rats were divided into 2 groups. Group DAG (n=9) rats were given AG hydrogen carbonate (1 g/L) in drinking water and group D (n=8) was diabetic control rats given only tap water. Group H (n=8) was followed as healthy controls. At the end of an 8 week period, NO release, lipid and protein oxidation were determined in kidney tissues. NO release was significantly lower in diabetic rats compared with healthy controls (p<0.05). Lipid peroxidation was significantly high in group D (3.9 ± 0.3 nmol MDA/g tissue) compared with the group DAG (2.6 ± 0.1 nmol MDA/g tissue, p<0.01) and group H (2.4 ± 0.2 nmol MDA/g tissue). Protein oxidation was significantly higher in diabetics than healthy controls (563.8 ± 23.9, 655.8 ± 7.2, 431.5 ± 8.8 mmol carbonyl/g tissue for group DAG, D and H, respectively, p< 0.05). A positive correlation between albuminuria and thiobarbituric acid reactive substance (TBARS) levels (r= 0.54, p<0.005) and carbonyl content (r=0.70, p<0.0005) in kidney homogenate were observed. Although AG treatment had no effect on NO release, it significantly decreased lipid peroxidation in diabetic rat cortices. Consequently increased lipid peroxidation -as well as- protein oxidation could be involved in the pathogenesis of diabetic albuminuria.
dc.identifier.doi10.1080/15604280214487
dc.identifier.issn15604284
dc.identifier.pubmed11991200
dc.identifier.urihttps://hdl.handle.net/11424/248332
dc.language.isoeng
dc.relation.ispartofInternational Journal of Experimental Diabetes Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEffects of aminoguanidine on lipid and protein oxidation in diabetic rat kidneys
dc.typereview
dspace.entity.typePublication
local.avesis.id3db0492f-d5dc-481a-8a74-fb6f72254a40
local.import.packageSS22
local.import.sourceScopus
local.indexed.atSCOPUS
local.indexed.atPUBMED
oaire.citation.endPage151
oaire.citation.issue2
oaire.citation.startPage145
oaire.citation.titleInternational Journal of Experimental Diabetes Research
oaire.citation.volume3
relation.isAuthorOfPublication7a2bc583-aab6-43e7-9cc3-0d7a60773409
relation.isAuthorOfPublication.latestForDiscovery7a2bc583-aab6-43e7-9cc3-0d7a60773409

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