Publication:
The angiogenic gene profile of pulmonary endarterectomy specimens: Initial study

Simple item page
dc.contributor.authorERMERAK, NEZİH ONUR
dc.contributor.authorYILMAZ, BETÜL
dc.contributor.authorBATIREL, SAİME
dc.contributor.authorOLGUN YILDIZELİ, ŞEHNAZ
dc.contributor.authorKOCAKAYA, DERYA
dc.contributor.authorMUTLU, BÜLENT
dc.contributor.authorYILDIZELİ, BEDRETTİN
dc.contributor.authorsERMERAK N. O., YILMAZ B., BATIREL S., OLGUN YILDIZELİ Ş., KOCAKAYA D., MUTLU B., Tas S., YILDIZELİ B.
dc.date.accessioned2023-02-20T10:43:05Z
dc.date.available2023-02-20T10:43:05Z
dc.date.issued2023-01-01
dc.description.abstract© 2023 The Author(s)Objectives: The underlying mechanisms for the development of chronic thromboembolic pulmonary hypertension and prognostic biomarkers are not clear yet. Thus, our aim is to assess and identify new biomarkers for the expression of 84 key genes linked to angiogenesis. Methods: Patients who had levels more than 1000 dynes·sec·cm−5 were included in the test group, and the other patients were included in the control group. Twelve specimens were taken from the patients. RT2 Profiler PCR Array (Qiagen) was used to quantify the expression of the 84 key genes. Results: Eight patients (6 male, 2 female, median age 54.4 ± 13.1 years) who underwent pulmonary endarterectomy were included. Pulmonary vascular resistance improved significantly from 811 ± 390 dyn/s/cm−5 to 413.3 ± 144.9 dyn/s/cm−5 (P .005) after surgery. Median length of hospital stay was 11.62 ± 2.97 days. The test group had a distinct pattern of impaired angiogenic and antiangiogenic genes. The expression levels of TGFA, TGFB1, THBS2, THBS1, TGFBR1, SERPINE1, SERPINF1, TGFB2, TIMP2, VEGFC, IFNA1, TNF, CXCL10, NOS3, IGF1, and MMP14 were downregulated in the specimens from the patients who had higher pulmonary vascular resistance values, whereas some genes, including PDGFA, showed upregulation that was statistically nonsignificant in the same group. Conclusions: These results can lead to the development of new markers that could predict adverse outcomes of patients with CTEPH. Identification of new markers that are related to worse outcomes would enable screening patients for early diagnosis and treatment.
dc.identifier.citationERMERAK N. O., YILMAZ B., BATIREL S., OLGUN YILDIZELİ Ş., KOCAKAYA D., MUTLU B., Tas S., YILDIZELİ B., "The angiogenic gene profile of pulmonary endarterectomy specimens: Initial study", JTCVS Open, 2023
dc.identifier.doi10.1016/j.xjon.2022.12.010
dc.identifier.endpage12
dc.identifier.issn2666-2736
dc.identifier.startpage1
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85147386604&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/286591
dc.language.isoeng
dc.relation.ispartofJTCVS Open
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectGöğüs Hastalıkları ve Allerji
dc.subjectKardiyoloji
dc.subjectCerrahi Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectChest Diseases and Allergy
dc.subjectCardiovascular
dc.subjectSurgery Medicine Sciences
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectCERRAHİ
dc.subjectSOLUNUM SİSTEMİ
dc.subjectKALP VE KALP DAMAR SİSTEMLERİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectSURGERY
dc.subjectRESPIRATORY SYSTEM
dc.subjectCARDIAC & CARDIOVASCULAR SYSTEMS
dc.subjectCerrahi
dc.subjectAkciğer ve Solunum Tıbbı
dc.subjectKardiyoloji ve Kardiyovasküler Tıp
dc.subjectSurgery
dc.subjectPulmonary and Respiratory Medicine
dc.subjectCardiology and Cardiovascular Medicine
dc.subjectangiogenesis
dc.subjectchronic thromboembolic pulmonary hypertension
dc.subjectgene expression
dc.titleThe angiogenic gene profile of pulmonary endarterectomy specimens: Initial study
dc.typearticle
dspace.entity.typePublication
local.avesis.id30cd5bac-f6e8-4047-bc60-914d37c7c559
local.indexed.atSCOPUS
relation.isAuthorOfPublicationa222ea0d-ad32-4e7e-b052-db1d35be2d78
relation.isAuthorOfPublication436b0529-96a0-4b86-bd25-2b0455497b85
relation.isAuthorOfPublication819f23bf-7f20-4c27-95c0-15d1a199b19d
relation.isAuthorOfPublicationb296649a-f0a5-4a54-bb27-a2ee07946dd9
relation.isAuthorOfPublication2771cdd6-7c3b-45a8-89fe-a429a2950516
relation.isAuthorOfPublicationeed1d57d-2fc5-4da3-ab50-89ce22ccf43a
relation.isAuthorOfPublicationd6b68c67-eea7-4dc3-8688-e8cfbe3bbcd2
relation.isAuthorOfPublication.latestForDiscoverya222ea0d-ad32-4e7e-b052-db1d35be2d78

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
30.pdf
Size:
1.85 MB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs