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Patch-Based Technology for Corneal Microbial Keratitis

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dc.contributor.authorAKSU, MEHMET BURAK
dc.contributor.authorsUlag S., Ilhan E., Aksu B., Sengor M., Ekren N., Kilic O., Gunduz O.
dc.date.accessioned2022-03-15T02:15:52Z
dc.date.available2022-03-15T02:15:52Z
dc.date.issued2020
dc.description.abstractCorneal opacities, which happened mainly due to microbial keratitis, are the fourth cause of blindness worldwide. Antimicrobial therapy is an alternative solution for microbial keratitis caused by Staphylococcus aureus and Pseudomonas Aeruginosa. The aim of this study, to develop patches for the treatment of corneal keratitis which caused significant corneal blindness by using electrospinning method. Polyvinyl-alcohol (PVA) patches with Gelatine (GEL) studied in various ratios. Different amounts of gelatine added to PVA to resemble the collagen fibril structure of the cornea. To enable the patches to the antimicrobial effect against the bacterias, the special plant extract was used. The produced corneal patches were examined separately for chemical, morphological, and antimicrobial properties. Scanning electron microscope (SEM), Fourier-transform infrared (FT-IR) spectroscopy were performed to observe the surface morphology and chemical structure of the patches, respectively. © Springer Nature Switzerland AG 2020.
dc.identifier.doi10.1007/978-3-030-45385-5_18
dc.identifier.isbn9783030453848
dc.identifier.issn3029743
dc.identifier.urihttps://hdl.handle.net/11424/248167
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBacterial keratitis
dc.subjectCorneal distropy
dc.subjectElectrospinning
dc.subjectNanofiber patches
dc.subjectPropolis
dc.titlePatch-Based Technology for Corneal Microbial Keratitis
dc.typeconferenceObject
dspace.entity.typePublication
local.avesis.id8435aa77-1438-4275-abd8-c22f55c1b282
local.conference.title8th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2020
local.import.packageSS21
local.import.sourceScopus
local.indexed.atSCOPUS
oaire.citation.endPage200
oaire.citation.startPage194
oaire.citation.titleLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
oaire.citation.volume12108 LNBI
relation.isAuthorOfPublicationf7de5699-7a5c-4496-93cf-d8daba79da4f
relation.isAuthorOfPublication.latestForDiscoveryf7de5699-7a5c-4496-93cf-d8daba79da4f

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