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Inhibition of substance P activity prevents stress-induced bladder damage

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dc.contributor.authorAKICI, AHMET
dc.contributor.authorsErcan, F; Akici, A; Ersoy, Y; Hurdag, C; Erin, N
dc.date.accessioned2022-03-12T17:20:38Z
dc.date.available2022-03-12T17:20:38Z
dc.date.issued2006
dc.description.abstractSubstance P is a neuropeptide involved in inflammation, immune regulation and stress response. Stress may induce bladder damage by stimulating inflammatory response such as mast cell activation. We here examined the role substance P during stress-induced mast cell degranulation and urothelial injury in rat bladder. Adult Sprague-Dawley rats (200-270 g) were either exposed to cold-immobilization stress or substance P (SP) intracerebroventricularly. Different doses of substance P receptor (NK1R) antagonist CP 99994 were administered peripherally or centrally before the stress exposure. From each group, samples of the bladder were examined with light and electron microscope. Stress- and SP-injected centrally, increased the number of both granulated and degranulated mast cells. Ultrastructurally, urothelial degeneration with vacuolization in the cytoplasm and dilated intercellular spaces were seen. Both central and peripheral injection of CP 99994 prevented stress-induced urothelial degeneration as well as stress-induced mast cell degranulation. In conclusion, centrally and peripherally released substance P is involved in stress-induced bladder damage. Inhibition of NK1R prevents stress-induced pathological changes of urinary bladder and NK1R antagonist can be considered for the treatment of inflammatory bladder diseases. (c) 2005 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.regpep.2005.09.024
dc.identifier.eissn1873-1686
dc.identifier.issn0167-0115
dc.identifier.pubmed16239038
dc.identifier.urihttps://hdl.handle.net/11424/228260
dc.identifier.wosWOS:000234796200013
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofREGULATORY PEPTIDES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectstress-induced mast cell degranulation
dc.subjectSP
dc.subjectNK1R
dc.subjectNK1 RECEPTOR
dc.subjectINTERSTITIAL CYSTITIS
dc.subjectHIPPOCAMPUS
dc.subjectANTAGONIST
dc.subjectEXPRESSION
dc.subjectTACHYKININ
dc.subjectNEURONS
dc.subjectNUMBER
dc.subjectNERVES
dc.subjectMICE
dc.titleInhibition of substance P activity prevents stress-induced bladder damage
dc.typearticle
dspace.entity.typePublication
local.avesis.id85ed347e-683f-498a-8a3b-32a2ffbc7d77
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage89
oaire.citation.issue1-3
oaire.citation.startPage82
oaire.citation.titleREGULATORY PEPTIDES
oaire.citation.volume133
relation.isAuthorOfPublication6c7c9f26-63a9-4f6f-91cd-aa9e3452919c
relation.isAuthorOfPublication.latestForDiscovery6c7c9f26-63a9-4f6f-91cd-aa9e3452919c

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