Publication: Association of serum irisin levels with body composition, metabolic profile, leptin, and adiponectin levels in lean and obese children
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Date
2023-11-05
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Abstract
Background and Objectives: Irisin is an adipo-myokine with potential metabolic effects in the
body, and its association with childhood obesity is still controversial. This study aimed to investigate
the relationship between serum irisin levels and anthropometric parameters, body composition,
metabolic profiles, leptin, and adiponectin in obese and normal-weight children. Methods: The
study sample consisted of a total of 80 children aged 6–10, including 44 obese children (BMI ≥ 97th
percentile) and 36 normal-weight children. Anthropometric parameters were measured. Body composition was determined with the use of the Bioelectrical Impedance Analysis (BIA) method. Metabolic
profiles, as well as irisin, leptin, and adiponectin levels, were analyzed. Results: Anthropometric
parameters and body composition were found to be significantly different between the obese and
normal-weight groups (p < 0.05). Fasting blood glucose, insulin, HOMA-IR, and leptin levels were
found to be significantly higher in the obese group, while the normal-weight group had significantly
higher HDL cholesterol and adiponectin levels (p < 0.05). Serum irisin levels did not differ between
the obese and normal-weight groups, or based on sex, vitamin D levels, and insulin resistance status.
There was also no statistically significant correlation between serum irisin levels and anthropometric
parameters, metabolic profile, leptin, and adiponectin. Conclusions: The study concluded that the
obese children who participated in this study had high leptin levels and low adiponectin levels, with
no significant difference in the irisin levels between the groups. More comprehensive clinical studies
are needed to investigate the relationship between irisin and adipokines in children.
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Keywords
childhood obesity, irisin, adiponectin, leptin, vitamin D
Citation
Esin K., Batirel S., Ülfer G., Yigit P., Sanlier N., "Association of Serum Irisin Levels with Body Composition, Metabolic Profile, Leptin, and Adiponectin Levels in Lean and Obese Children.", Medicina (Kaunas, Lithuania), cilt.59, sa.11, 2023