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The versatility of plectin in cancer: A pan-cancer analysis on potential diagnostic and prognostic impacts of plectin isoforms

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dc.contributor.authorARĞA, KAZIM YALÇIN
dc.contributor.authorsGundesli H., Kori M., ARGA K. Y.
dc.date.accessioned2023-06-19T07:52:16Z
dc.date.available2023-06-19T07:52:16Z
dc.date.issued2023-06-01
dc.description.abstractPlectin, encoded by PLEC, is a cytoskeletal and scaffold protein with a number of unique isoforms that act on various cellular functions such as cell adhesion, signal transduction, cancer cell invasion, and migration. While plectin has been shown to display high expression and mislocalization in tumor cells, our knowledge of the biological significance of plectin and its isoforms in tumorigenesis remain limited. In this study, we first performed pathway enrichment analysis to identify cancer hallmark proteins associated with plectin. Then, a pan-cancer analysis was performed using RNA-seq data collected from the Cancer Genome Atlas (TCGA) to detect the mRNA expression levels of PLEC and its transcript isoforms, and the prognostic as well as diagnostic significance of the transcript isoforms was evaluated considering cancer stages. We show here that several tissue specific PLEC isoforms are dysregulated in different cancer types and stages but not the expression of PLEC. Among them, PLEC 1d and PLEC 1f are potential biomarker candidates and call for further translational and personalized medicine research. This study makes a contribution as a stride to unravel the molecular mechanisms underpinning plectin isoforms in cancer development and progression by revealing the potent plectin isoforms in different stages of cancer as potential early cancer detection biomarkers. Importantly, uncovering how plectin isoforms guide malignancy and particular cancer types by comprehensive functional studies might open new avenues toward novel cancer therapeutics.
dc.identifier.citationGundesli H., Kori M., ARGA K. Y., "The Versatility of Plectin in Cancer: A Pan-Cancer Analysis on Potential Diagnostic and Prognostic Impacts of Plectin Isoforms", OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 2023
dc.identifier.doi10.1089/omi.2023.0053
dc.identifier.issn1536-2310
dc.identifier.urihttps://hdl.handle.net/11424/290392
dc.language.isoeng
dc.relation.ispartofOMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Genetik
dc.subjectYaşam Bilimleri
dc.subjectBiyoteknoloji
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectMedical Genetics
dc.subjectLife Sciences
dc.subjectBiotechnology
dc.subjectMolecular Biology and Genetics
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectBİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ
dc.subjectMikrobiyoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectGENETİK VE KALITIM
dc.subjectBIOTECHNOLOGY & APPLIED MICROBIOLOGY
dc.subjectMICROBIOLOGY
dc.subjectLife Sciences (LIFE)
dc.subjectGENETICS & HEREDITY
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectGenetik (klinik)
dc.subjectUygulamalı Mikrobiyoloji ve Biyoteknoloji
dc.subjectMoleküler Tıp
dc.subjectMoleküler Biyoloji
dc.subjectGenetik
dc.subjectGenetics (clinical)
dc.subjectApplied Microbiology and Biotechnology
dc.subjectMolecular Medicine
dc.subjectMolecular Biology
dc.subjectGenetics
dc.subjectplectin
dc.subjectplectin isoforms
dc.subjectcarcinogenesis
dc.subjectprognostic biomarker
dc.subjectdiagnostic biomarker
dc.subjectpersonalized medicine
dc.subjectINTERMEDIATE-FILAMENT
dc.subjectCARCINOMA-CELLS
dc.subjectEXPRESSION
dc.subjectINVASION
dc.subjectMUSCLE
dc.subjectSKIN
dc.subjectINVADOPODIA
dc.subjectDISRUPTION
dc.subjectCOMPLEXITY
dc.subjectINTEGRITY
dc.titleThe versatility of plectin in cancer: A pan-cancer analysis on potential diagnostic and prognostic impacts of plectin isoforms
dc.typearticle
dspace.entity.typePublication
local.avesis.id1f2228e0-26c2-4f43-9d79-f677d3505279
local.indexed.atWOS
local.indexed.atPUBMED
relation.isAuthorOfPublication3582c2d4-7fbb-4db7-8e90-75613782b894
relation.isAuthorOfPublication.latestForDiscovery3582c2d4-7fbb-4db7-8e90-75613782b894

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