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A pan-cancer atlas of differentially interacting hallmarks of cancer proteins

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dc.contributor.authorARĞA, KAZIM YALÇIN
dc.contributor.authorsKori M., Ozdemir G. E., ARĞA K. Y., Sinha R.
dc.date.accessioned2023-01-02T11:45:13Z
dc.date.available2023-01-02T11:45:13Z
dc.date.issued2022-11-01
dc.description.abstractCancer hallmark genes and proteins orchestrate and drive carcinogenesis to a large extent, therefore, it is important to study these features in different cancer types to understand the process of tumorigenesis and discover measurable indicators. We performed a pan-cancer analysis to map differentially interacting hallmarks of cancer proteins (DIHCP). The TCGA transcriptome data associated with 12 common cancers were analyzed and the differential interactome algorithm was applied to determine DIHCPs and DIHCP-centric modules (i.e., DIHCPs and their interacting partners) that exhibit significant changes in their interaction patterns between the tumor and control phenotypes. The diagnostic and prognostic capabilities of the identified modules were assessed to determine the ability of the modules to function as system biomarkers. In addition, the druggability of the prognostic and diagnostic DIHCPs was investigated. As a result, we found a total of 30 DIHCP-centric modules that showed high diagnostic or prognostic performance in any of the 12 cancer types. Furthermore, from the 16 DIHCP-centric modules examined, 29% of these were druggable. Our study presents candidate systems\" biomarkers that may be valuable for understanding the process of tumorigenesis and improving personalized treatment strategies for various cancers, with a focus on their ten hallmark characteristics.
dc.identifier.citationKori M., Ozdemir G. E., ARĞA K. Y., Sinha R., "A Pan-Cancer Atlas of Differentially Interacting Hallmarks of Cancer Proteins", JOURNAL OF PERSONALIZED MEDICINE, cilt.12, sa.11, 2022
dc.identifier.doi10.3390/jpm12111919
dc.identifier.issn2075-4426
dc.identifier.issue11
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/3cb7857a-a7a0-4fe1-9850-17acffb0bc04/file
dc.identifier.urihttps://hdl.handle.net/11424/284696
dc.identifier.volume12
dc.language.isoeng
dc.relation.ispartofJOURNAL OF PERSONALIZED MEDICINE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectAile Hekimliği
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectFamily Medicine
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectSAĞLIK BAKIM BİLİMLERİ VE HİZMETLERİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectHEALTH CARE SCIENCES & SERVICES
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectTıbbi Terminoloji
dc.subjectTıbbi Sekreterlik ve Transkripsiyon
dc.subjectSağlık Bilgi Yönetimi
dc.subjectSağlık Meslekleri (çeşitli)
dc.subjectGenel Sağlık Meslekleri
dc.subjectGözden Geçirme ve Sınav Hazırlığı
dc.subjectPatofizyoloji
dc.subjectLiderlik ve Yönetim
dc.subjectTemel Bilgi ve Beceriler
dc.subjectToplum Sağlığı ve Evde Bakım
dc.subjectBakım Planlaması
dc.subjectDeğerlendirme ve Teşhis
dc.subjectDahiliye
dc.subjectSağlık Politikaları
dc.subjectAile Sağlığı
dc.subjectTıp (çeşitli)
dc.subjectGenel Tıp
dc.subjectMedical Terminology
dc.subjectMedical Assisting and Transcription
dc.subjectHealth Information Management
dc.subjectHealth Professions (miscellaneous)
dc.subjectGeneral Health Professions
dc.subjectReview and Exam Preparation
dc.subjectPathophysiology
dc.subjectLeadership and Management
dc.subjectFundamentals and Skills
dc.subjectCommunity and Home Care
dc.subjectCare Planning
dc.subjectAssessment and Diagnosis
dc.subjectInternal Medicine
dc.subjectHealth Policy
dc.subjectFamily Practice
dc.subjectMedicine (miscellaneous)
dc.subjectGeneral Medicine
dc.subjecthallmarks of cancer
dc.subjectdifferential interactome
dc.subjectsystem biomarkers
dc.subjectdruggability
dc.subjectpersonalized treatments
dc.subjectBIOMARKERS
dc.subjecthallmarks of cancer
dc.subjectdifferential interactome
dc.subjectsystem biomarkers
dc.subjectdruggability
dc.subjectpersonalized treatments
dc.titleA pan-cancer atlas of differentially interacting hallmarks of cancer proteins
dc.typearticle
dspace.entity.typePublication
local.avesis.id3cb7857a-a7a0-4fe1-9850-17acffb0bc04
local.indexed.atWOS
local.indexed.atPUBMED
relation.isAuthorOfPublication3582c2d4-7fbb-4db7-8e90-75613782b894
relation.isAuthorOfPublication.latestForDiscovery3582c2d4-7fbb-4db7-8e90-75613782b894

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