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Theophylline-loaded pectin-based hydrogels. II. Effect of concentration of initial pectin solution, crosslinker type and cation concentration of external solution on drug release profile

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dc.contributor.authorBATIREL, SAİME
dc.contributor.authorsSarioglu, Ebru; Kocaaga, Banu Arabacioglu; Turan, Deniz; Batirel, Saime; Guner, F. Seniha
dc.date.accessioned2022-03-12T22:38:05Z
dc.date.available2022-03-12T22:38:05Z
dc.date.issued2019
dc.description.abstractA series of drug-loaded pectin hydrogels were prepared by mixing method in two ion types, Ca+2 or Zn+2, for wound dressing applications and their drug release performances were investigated at pH 6.4 in four different calcium ion concentrations of external solution. Pectin hydrogels were synthesized in three different concentrations of initial pectin solution and theophylline was used as a model drug. Fourier transform infrared spectroscopy, scanning electron microscopy, and atomic force microscopy were used for hydrogel characterization. Additionally, fluid handling capacity, swelling behavior, dehydration rate, dispersion characteristic, dressing pH determination, water vapor permeability, oxygen permeability, surface contact angle, flexibility, mass per unit area, and thickness were determined for selected hydrogels. One of the most valuable contributions of our study is that the concentration of initial pectin solution and calcium ion concentration of external solution are very important parameters to obtain an effective drug release. After evaluating all data, we have shown that flexible and transparent pectin-based wound dressings can be synthesized as a controlled drug release system. Zinc-containing hydrogel was antibacterial against Staphylococcus aureus and Escherichia coli but not suitable for cell migration. On the other hand, calcium-based hydrogel was nontoxic on the fibroblast cells and it had no negative effect on cell migration. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48155.
dc.identifier.doi10.1002/app.48155
dc.identifier.eissn1097-4628
dc.identifier.issn0021-8995
dc.identifier.urihttps://hdl.handle.net/11424/235481
dc.identifier.wosWOS:000473553800001
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofJOURNAL OF APPLIED POLYMER SCIENCE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectantibacterial activity
dc.subjectcytotoxicity activity
dc.subjecthydrogel
dc.subjectpectin
dc.subjecttheophylline
dc.subjectZINC-OXIDE NANOPARTICLES
dc.subjectBIOMEDICAL APPLICATIONS
dc.subjectWOUND DRESSINGS
dc.subjectCITRUS PECTIN
dc.subjectCALCIUM
dc.subjectANTIBACTERIAL
dc.subjectALGINATE
dc.subjectBINDING
dc.subjectTHIOCYANATE
dc.subjectMONOVALENT
dc.titleTheophylline-loaded pectin-based hydrogels. II. Effect of concentration of initial pectin solution, crosslinker type and cation concentration of external solution on drug release profile
dc.typearticle
dspace.entity.typePublication
local.avesis.id98a4188a-dc32-4250-8b30-e1ce4a43191c
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.articlenumber48155
local.journal.numberofpages15
local.journal.quartileQ2
oaire.citation.issue43
oaire.citation.titleJOURNAL OF APPLIED POLYMER SCIENCE
oaire.citation.volume136
relation.isAuthorOfPublication819f23bf-7f20-4c27-95c0-15d1a199b19d
relation.isAuthorOfPublication.latestForDiscovery819f23bf-7f20-4c27-95c0-15d1a199b19d

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