Publication:
Cellular Protection and Therapeutic Potential of Tocotrienols

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dc.contributor.authorYILMAZ, BETÜL
dc.contributor.authorsCatalgol, Betul; Batirel, Saime; Ozer, Nesrin Kartal
dc.date.accessioned2022-03-10T15:25:07Z
dc.date.available2022-03-10T15:25:07Z
dc.date.issued2011
dc.description.abstractTocotrienols, components belonging to vitamin E members, are used as potent therapeutics in the treatment of several diseases. Recent studies suggested tocotrienol to have better activity in many situations compared to tocopherols. Tocotrienols have been shown to lower the atherogenic apolipoprotein B and lipoprotein plasma levels. Additionally, tocotrienols with their anti-tumor effect together with anti-angiogenic and anti-thrombotic effects may serve as effective agents in cancer therapy. Besides these effects, some properties such as water insolubility and low stability limit the usage of tocotrienols in the clinic. However recent studies tried to increase the bioavailability with esterification and combination use. These efforts for the clinical usage of tocotrienols which may help them to take a wide place in the clinic and additional studies are needed to identify their therapeutical mechanisms.
dc.identifier.doi10.2174/138161211796957436
dc.identifier.eissn1873-4286
dc.identifier.issn1381-6128
dc.identifier.pubmed21774780
dc.identifier.urihttps://hdl.handle.net/11424/220113
dc.identifier.wosWOS:000299624400009
dc.language.isoeng
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.relation.ispartofCURRENT PHARMACEUTICAL DESIGN
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTocotrienols
dc.subjectatherosclerosis
dc.subjectAlzheimer's disease
dc.subjectcancer
dc.subjecttherapy
dc.subjectVITAMIN-E ACTION
dc.subjectALPHA-TOCOPHEROL
dc.subjectGAMMA-TOCOTRIENOL
dc.subjectOXIDATIVE STRESS
dc.subjectALZHEIMERS-DISEASE
dc.subjectPROSTATE-CANCER
dc.subjectMOLECULAR-BASIS
dc.subjectKAPPA-B
dc.subjectANTIOXIDANT PROPERTIES
dc.subjectDELTA-TOCOTRIENOL
dc.titleCellular Protection and Therapeutic Potential of Tocotrienols
dc.typereview
dspace.entity.typePublication
local.avesis.id1bed5a4c-1a18-40aa-8dbc-a930e08fe5ca
local.import.packageSS5
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage2220
oaire.citation.issue21
oaire.citation.startPage2215
oaire.citation.titleCURRENT PHARMACEUTICAL DESIGN
oaire.citation.volume17
relation.isAuthorOfPublication81633a07-e5fb-4760-b3ef-bf0878d87827
relation.isAuthorOfPublication.latestForDiscovery81633a07-e5fb-4760-b3ef-bf0878d87827

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