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A drug-eluting nanofibrous hyaluronic acid-keratin mat for diabetic wound dressing

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dc.contributor.authorEKREN, NAZMİ
dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorsSu S., Bedir T., KALKANDELEN C., Sasmazel H. T. , Basar A. O. , Chen J., EKREN N., GÜNDÜZ O.
dc.date.accessioned2022-10-17T13:23:55Z
dc.date.available2022-10-17T13:23:55Z
dc.date.issued2022-01-01
dc.description.abstract© 2022, Qatar University and Springer Nature Switzerland AG.Diabetes mellitus is a chronic metabolic disease associated with long-term multisystem complications, among which are non-healing diabetic foot ulcers (DFUs). Electrospinning is a sophisticated technique for the preparation of polymeric nanofibers impregnated with drugs for wound healing, burns, and diabetic ulcers. This study describes the fabrication and characterization of a novel drug-eluting dressing made of core–shell structured hyaluronic acid (HA)–keratin (KR)-polyethylene oxide (PEO) and polycaprolactone (PCL) nanofibers to treat diabetic wounds. The core–shell nanofibers produced by the emulsion electrospinning technique provide loading of metformin hydrochloride (MH), HA, and KR in the core of nanofibers, which in return improves the sustained long term release of the drug and prolongs the bioactivity. Morphological and chemical properties of the fibers were examined by SEM, FTIR, and XRD studies. It was observed that the fibers which contain HA and KR showed thin fiber structure, greater swelling capacity, fast degradation and increased cumulative drug release amount than neat emulsion fibers due to the hydrophilic nature of HA and KR. MH showed a sustained release from all fiber samples over 20 days and followed the first-order and Higuchi model kinetics and Fickian diffusion mechanism according to kinetic analysis results. In vitro cell culture studies showed that the developed mats exhibited enhanced biocompatibility performance with HA and KR incorporation. The results show that HA and KR-based emulsion electrospun fiber mats are potentially useful new nanofiber-based biomaterials in their use as drug carriers to treat diabetic wounds.
dc.identifier.citationSu S., Bedir T., KALKANDELEN C., Sasmazel H. T. , Basar A. O. , Chen J., EKREN N., GÜNDÜZ O., "A drug-eluting nanofibrous hyaluronic acid-keratin mat for diabetic wound dressing", Emergent Materials, 2022
dc.identifier.doi10.1007/s42247-022-00418-3
dc.identifier.issn2522-5731
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85139258446&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/282392
dc.language.isoeng
dc.relation.ispartofEmergent Materials
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectTarım Makineleri
dc.subjectTarımda Enerji
dc.subjectBiyoyakıt Teknolojisi
dc.subjectMühendislik ve Teknoloji
dc.subjectAgricultural Sciences
dc.subjectAgriculture
dc.subjectFarm Machinery
dc.subjectEnergy in Agriculture
dc.subjectBiofuels Technology
dc.subjectEngineering and Technology
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectMühendislik
dc.subjectMalzeme Bilimi
dc.subjectMÜHENDİSLİK, ÇEVRE
dc.subjectENERJİ VE YAKITLAR
dc.subjectMALZEME BİLİMİ, BİYOMATERYAL
dc.subjectMALZEME BİLİMİ, SERAMİK
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectENGINEERING
dc.subjectMATERIALS SCIENCE
dc.subjectENGINEERING, ENVIRONMENTAL
dc.subjectENERGY & FUELS
dc.subjectMATERIALS SCIENCE, BIOMATERIALS
dc.subjectMATERIALS SCIENCE, CERAMICS
dc.subjectSeramik ve Kompozitler
dc.subjectFizik Bilimleri
dc.subjectBiyomalzemeler
dc.subjectYenilenebilir Enerji, Sürdürülebilirlik ve Çevre
dc.subjectAtık Yönetimi ve Bertarafı
dc.subjectCeramics and Composites
dc.subjectPhysical Sciences
dc.subjectBiomaterials
dc.subjectRenewable Energy, Sustainability and the Environment
dc.subjectWaste Management and Disposal
dc.subjectDrug release
dc.subjectEmulsion electrospinning
dc.subjectMetformin hydrochloride
dc.subjectNatural polymers
dc.subjectWound healing
dc.titleA drug-eluting nanofibrous hyaluronic acid-keratin mat for diabetic wound dressing
dc.typearticle
dspace.entity.typePublication
local.avesis.ide6f9e890-3dbc-4c6e-b42b-0db5ce4f5a84
local.indexed.atSCOPUS
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relation.isAuthorOfPublicationf11e8073-bf2f-485f-9bdf-5b3a2a0bdc1f
relation.isAuthorOfPublication.latestForDiscoverybf8fa87c-9f12-4134-a6e3-274f1ec50ed9

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