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Mesenchymal stem cell therapy improves erectile dysfunction in experimental spinal cord injury

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dc.contributor.authorERTAŞ, BÜŞRA
dc.contributor.authorsAlbayrak, Omercan; Sener, Tarik Emre; Ersahin, Mehmet; Ozbas-Turan, Suna; Ekentok, Ceyda; Tavukcu, Hasan Huseyin; Cevik, Ozge; Cetinel, Sule; Ertas, Blisra; Sener, Goksel
dc.date.accessioned2022-03-12T22:44:27Z
dc.date.available2022-03-12T22:44:27Z
dc.date.issued2020
dc.description.abstractThe aim of this study is to investigate the therapeutic potential of adipose-derived mesenchymal stem cell (AD-MSC) from brown adipose tissue on erectile dysfunction (ED) in experimentally induced spinal cord injury in rats. 24 male Wistar rats were divided into 3 groups; control, spinal cord injury (SCI) + vehicle, and SCI + AD-MSC. To induce SCI, a standard weight-drop method that induced a moderate to severe injury (100 g/cm force) at T7-T10, was used. AD-MSC (3 x 105 cells /5 mu L) was applied by local transplantation into the region of injury. At the end of four-weeks, rats underwent neurological examinations and then intracavernosal and mean arterial pressures (ICP and MAP) measurements. After decapitation, spinal cord and cavernosal tissue samples were taken to analyze neuronal nitric oxide synthase (n-NOS), proto-oncogene protein c-FOS and nerve growth factor (NGF). Tissues were also examined histologically. Spinal cord injury caused decrease on NGF and n-NOS levels while c-FOS was increased. The ICP/MAP value in vehicle-treated SCI rats was found to be significantly higher than the control group. On the other hand, in SCI + AD-MSC group, all these parameters were reversed back to control levels. AD-MSC therapy may be beneficial against erectile dysfunction in experimentally induced SCI by ameliorating neuronal damage.
dc.identifier.doi10.1038/s41443-019-0168-1
dc.identifier.eissn1476-5489
dc.identifier.issn0955-9930
dc.identifier.pubmed31273327
dc.identifier.urihttps://hdl.handle.net/11424/236431
dc.identifier.wosWOS:000533676400009
dc.language.isoeng
dc.publisherSPRINGERNATURE
dc.relation.ispartofINTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTADALAFIL TREATMENT
dc.subjectRAT
dc.subjectDIFFERENTIATION
dc.subjectTRANSPLANTATION
dc.subjectEXPRESSION
dc.subjectFAT
dc.titleMesenchymal stem cell therapy improves erectile dysfunction in experimental spinal cord injury
dc.typearticle
dspace.entity.typePublication
local.avesis.id3bf74f49-25e5-4811-be88-debdc43c7d45
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
local.journal.quartileQ2
oaire.citation.endPage316
oaire.citation.issue3
oaire.citation.startPage308
oaire.citation.titleINTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
oaire.citation.volume32
relation.isAuthorOfPublication864e7cb0-b39f-48bb-a546-ee65ffc807b2
relation.isAuthorOfPublication.latestForDiscovery864e7cb0-b39f-48bb-a546-ee65ffc807b2

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