Publication:
Phenotypic pattern of early versus later-onset pediatric inflammatory bowel disease in a eurasian country

Simple item page
dc.contributor.authorERTEM ŞAHİNOĞLU, DENİZ
dc.contributor.authorsAkkelle B. S., Ertem D., Volkan B., Tutar E.
dc.date.accessioned2023-08-08T07:57:48Z
dc.date.available2023-08-08T07:57:48Z
dc.date.issued2022-10-01
dc.description.abstractObjectives: It is not clear whether the characteristics of pediatric inflammatory bowel disease (IBD) differ between Eastern and Western countries. The aim of this study was to analyze the characteristics of PIBD in Turkey, according to the age at diagnosis. Methods: The data of 176 children with IBD who were followed in our center were analyzed. Patients were divided into early (EO-IBD, onset at 2 to <10 years) and later-onset (LO-IBD, 10 to <= 17 years) IBD according to the age at diagnosis. Patients\" data with ulcerative colitis (UC) and Crohn\"s disease (CD) were compared. Results: Of 176 patients, 47 (26.7%) were diagnosed with EO-IBD. Patients with early-onset ulcerative colitis (EO-UC) had the highest rate of family history of IBD (17.6%). Pancolitis was the most common form of UC regardless of the age at onset. The rate of moderate-severe disease activity in later-onset UC (62.5%) was higher than in EO-UC (37.5%). A higher rate of extraintestinal manifestations was observed in EO-IBD patients, particularly in EO-UC (38.2%) than in LO-IBD patients. Patients with early-onset CD (EO-CD) had predominantly colonic involvement and nonstricturing, nonpenetrating disease behavior. The rate of perianal disease in patients with later-onset CD (LO-CD) (64.5%) was noticeably higher than those with EO-CD (23%). Conclusions: Our results suggest that patients with EO-UC represented a distinct phenotype with a mild disease activity, high rate of extraintestinal symptoms, and a high proportion of family history. The analysis of our IBD cohort also demonstrated remarkably high rate of perianal disease, particularly in patients with LO-CD.
dc.identifier.citationAkkelle B. S., Ertem D., Volkan B., Tutar E., "Phenotypic Pattern of Early Versus Later-Onset Pediatric Inflammatory Bowel Disease in a Eurasian Country", JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, cilt.75, sa.4, 2022
dc.identifier.doi10.1097/mpg.0000000000003557
dc.identifier.endpage66
dc.identifier.issn0277-2116
dc.identifier.issue4
dc.identifier.startpage61
dc.identifier.urihttps://journals.lww.com/jpgn/Fulltext/2022/10000/Phenotypic_Pattern_of_Early_Versus_Later_Onset.17.aspx
dc.identifier.urihttps://hdl.handle.net/11424/292182
dc.identifier.volume75
dc.language.isoeng
dc.relation.ispartofJOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectÇocuk Sağlığı ve Hastalıkları
dc.subjectİç Hastalıkları
dc.subjectGastroenteroloji-(Hepatoloji)
dc.subjectBeslenme ve Dietetik
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectChild Health and Diseases
dc.subjectInternal Diseases
dc.subjectGastroenterology and Hepatology
dc.subjectNutrition and Dietetics
dc.subjectAgricultural Sciences
dc.subjectAgriculture
dc.subjectHealth Sciences
dc.subjectGASTROENTEROLOJİ VE HEPATOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectBESLENME VE DİYETETİK
dc.subjectTarım Bilimleri
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectPEDİATRİ
dc.subjectGASTROENTEROLOGY & HEPATOLOGY
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectNUTRITION & DIETETICS
dc.subjectAGRICULTURAL SCIENCES
dc.subjectAgriculture & Environment Sciences (AGE)
dc.subjectPEDIATRICS
dc.subjectPediatri
dc.subjectBeslenme ve Diyetetik
dc.subjectPediatri, Perinatoloji ve Çocuk Sağlığı
dc.subjectHepatoloji
dc.subjectGastroenteroloji
dc.subjectPediatrics
dc.subjectPediatrics, Perinatology and Child Health
dc.subjectHepatology
dc.subjectGastroenterology
dc.subjectearly-onset
dc.subjectinflammatory bowel disease
dc.subjectpediatric
dc.subjectphenotype
dc.subjectCROHNS-DISEASE
dc.subjectRISING INCIDENCE
dc.subjectNATURAL-HISTORY
dc.subjectCHILDREN
dc.subjectEPIDEMIOLOGY
dc.subjectDIAGNOSIS
dc.subjectAGE
dc.subjectVALIDATION
dc.subjectOUTCOMES
dc.titlePhenotypic pattern of early versus later-onset pediatric inflammatory bowel disease in a eurasian country
dc.typearticle
dspace.entity.typePublication
local.avesis.id37736296-d11f-429a-9784-038539b73d9f
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicatione1f19d32-05e2-4206-864e-f3936b370d99
relation.isAuthorOfPublication.latestForDiscoverye1f19d32-05e2-4206-864e-f3936b370d99

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
3.pdf
Size:
398.4 KB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs