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Hydroxyapatite thin films of marine origin as sustainable candidates for dental implants

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dc.contributor.authorOKTAR, FAİK NÜZHET
dc.contributor.authorsDorcioman G., Grumezescu V., Stan G. E., Chifiriuc M. C., Gradisteanu G. P., Miculescu F., Matei E., Popescu-Pelin G., Zgura I., Craciun V., et al.
dc.date.accessioned2023-05-15T12:06:40Z
dc.date.available2023-05-15T12:06:40Z
dc.date.issued2023-04-01
dc.description.abstractNovel biomaterials with promising bone regeneration potential, derived from rich, renewable, and cheap sources, are reported. Thus, thin films were synthesized from marine-derived (i.e., from fish bones and seashells) hydroxyapatite (MdHA) by pulsed laser deposition (PLD) technique. Besides the physical–chemical and mechanical investigations, the deposited thin films were also evaluated in vitro using dedicated cytocompatibility and antimicrobial assays. The morphological examination of MdHA films revealed the fabrication of rough surfaces, which were shown to favor good cell adhesion, and furthermore could foster the in-situ anchorage of implants. The strong hydrophilic behavior of the thin films was evidenced by contact angle (CA) measurements, with values in the range of 15–18°. The inferred bonding strength adherence values were superior (i.e., ~49 MPa) to the threshold established by ISO regulation for high-load implant coatings. After immersion in biological fluids, the growth of an apatite-based layer was noted, which indicated the good mineralization capacity of the MdHA films. All PLD films exhibited low cytotoxicity on osteoblast, fibroblast, and epithelial cells. Moreover, a persistent protective effect against bacterial and fungal colonization (i.e., 1- to 3-log reduction of E. coli, E. faecalis, and C. albicans growth) was demonstrated after 48 h of incubation, with respect to the Ti control. The good cytocompatibility and effective antimicrobial activity, along with the reduced fabrication costs from sustainable sources (available in large quantities), should, therefore, recommend the MdHA materials proposed herein as innovative and viable solutions for the development of novel coatings for metallic dental implants.
dc.identifier.citationDorcioman G., Grumezescu V., Stan G. E., Chifiriuc M. C., Gradisteanu G. P., Miculescu F., Matei E., Popescu-Pelin G., Zgura I., Craciun V., et al., "Hydroxyapatite Thin Films of Marine Origin as Sustainable Candidates for Dental Implants", Pharmaceutics, cilt.15, sa.4, 2023
dc.identifier.doi10.3390/pharmaceutics15041294
dc.identifier.issn1999-4923
dc.identifier.issue4
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/e84fb81b-7ee0-4e78-add6-19b99c455911/file
dc.identifier.urihttps://hdl.handle.net/11424/289371
dc.identifier.volume15
dc.language.isoeng
dc.relation.ispartofPharmaceutics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTROPİKAL TIP
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectTROPICAL MEDICINE
dc.subjectFarmasötik bilim
dc.subjectYaşam Bilimleri
dc.subjectPharmaceutical Science
dc.subjectLife Sciences
dc.subjectmarine-derived hydroxyapatite thin film
dc.subjectbiomaterial
dc.subjectcytocompatibility
dc.subjectantimicrobial activity
dc.subjectdental implant
dc.subjectpulsed laser deposition (PLD)
dc.subjectPULSED-LASER DEPOSITION
dc.subjectBIOLOGICAL ASSESSMENT
dc.subjectCOMPOSITE
dc.subjectLITHIUM
dc.subjectENERGY
dc.titleHydroxyapatite thin films of marine origin as sustainable candidates for dental implants
dc.typearticle
dspace.entity.typePublication
local.avesis.ide84fb81b-7ee0-4e78-add6-19b99c455911
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication5ba0a0e0-ebae-43a6-855c-0aabb90021f4
relation.isAuthorOfPublication.latestForDiscovery5ba0a0e0-ebae-43a6-855c-0aabb90021f4

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