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C-reactive protein to albumin ratio is associated with disease activity in anti-neutrophil cytoplasmic antibody associated vasculitis

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dc.contributor.authorALİBAZ ÖNER, FATMA
dc.contributor.authorDİRESKENELİ, RAFİ HANER
dc.contributor.authorTUĞLULAR, ZÜBEYDE SERHAN
dc.contributor.authorAŞICIOĞLU, EBRU
dc.contributor.authorsAtas D. B., Sahin G. K., ŞENGÜL Ş., KAYA B., PAYDAŞ S., ALİBAZ ÖNER F., DİRESKENELİ R. H., TUĞLULAR Z. S., AŞICIOĞLU E.
dc.date.accessioned2023-04-24T08:34:23Z
dc.date.available2023-04-24T08:34:23Z
dc.date.issued2023-01-01
dc.description.abstractObjective/Aim: C-reactive protein to albumin ratio (CAR) has recently been recognized as an independent prognostic marker for vasculitides. This study aims to investigate CAR and its relationship with disease activity and damage in prevalent ANCA associated vasculitis (AAV) patients. Methods: Fifty-one patients with AAV and 42 age-sex-matched healthy controls were enrolled in this crosssectional study. Birmingham vasculitis score (BVAS) was used to assess vasculitis activity and vasculitis damage index (VDI) to provide information on disease damage. Results: The median (25th-75th) age of the patients were 55 (48-61) years. CAR was significantly higher in AAV patients than controls (1.9±2.7 vs 0.7±0.4; p=0.006). The 75th percentile of BVAS was defined as high BVAS (BVAS≥5) and ROC curve analysis showed that CAR≥0.98 predicted BVAS≥5 with 70.0% sensitivity and 68.0% specificity (AUC:0.660, CI: 0.482-0.837, p=0.049). When patients with CAR≥0.98 were compared to those without, BVAS [5.0 (3.5-8.0) vs. 2.0 (0-3.25), p<0.001], BVAS≥5 [16 (64.0%) vs 4 (15.4%) patients, p:0.001], VDI [4.0 (2.0-4.0) vs. 2.0 (1.0-3.0), p=0.006], and CAR [1.32 (1.07-3.78) vs. 0.75 (0.60-0.83), p<0.001] were higher whereas albumin [3.8 (3.1-4.3) vs. 4.1 (3.9-4.4) g/dL, p=0.025] and haemoglobin [12.1 (10.4-13.4) vs. 13.0 (12.5-14.2) g/dL, p=0.008] were lower. Multivariate analysis revealed that BVAS [OR(95% CI):1.313 (1.003-1.719), p=0.047] was an independent factor associated with CAR≥0.98 in patients with AAV. Furthermore, correlation analysis showed that CAR significantly correlated with BVAS (r: 0.466, p=0.001). Conclusion: In this study, we observed that CAR was significantly associated with disease activity in AAV patients and can be used to monitor disease activity
dc.identifier.citationAtas D. B., Sahin G. K., ŞENGÜL Ş., KAYA B., PAYDAŞ S., ALİBAZ ÖNER F., DİRESKENELİ R. H., TUĞLULAR Z. S., AŞICIOĞLU E., "C-Reactive Protein to Albumin Ratio is Associated with Disease Activity in Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis", Mediterranean Journal of Rheumatology, cilt.34, sa.1, ss.71-77, 2023
dc.identifier.doi10.31138/mjr.34.1.71
dc.identifier.endpage77
dc.identifier.issn2459-3516
dc.identifier.issue1
dc.identifier.startpage71
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85152284103&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/288875
dc.identifier.volume34
dc.language.isoeng
dc.relation.ispartofMediterranean Journal of Rheumatology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectİmmünoloji ve Romatoloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectImmunology and Rheumatology
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectROMATOLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectRHEUMATOLOGY
dc.subjectRomatoloji
dc.subjectRheumatology
dc.subjectANCA-associated vasculitis
dc.subjectBirmingham vasculitis activity score
dc.subjectC-reactive protein to albumin ratio
dc.subjectvasculitis damage index
dc.subjectANCA-associated vasculitis
dc.subjectBirmingham vasculitis activity score
dc.subjectC-reactive protein to albumin ratio
dc.subjectvasculitis damage index
dc.titleC-reactive protein to albumin ratio is associated with disease activity in anti-neutrophil cytoplasmic antibody associated vasculitis
dc.typearticle
dspace.entity.typePublication
local.avesis.id9230ef9a-7fb3-4930-98df-511c0441f4e6
local.indexed.atSCOPUS
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relation.isAuthorOfPublication07a34d26-21f3-475d-bd36-152d6c659370
relation.isAuthorOfPublication3ea0c6f9-3408-46b6-b382-144ccbf7bc72
relation.isAuthorOfPublication8d7fe885-fe9a-4e61-a77c-587df4c2adbe
relation.isAuthorOfPublication.latestForDiscoverye995a136-8c56-4192-bebe-fe522b567ef1

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