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Combined hamartoma of the retina and retinal pigment epithelium at pediatric age: surgical versus conservative approach

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dc.contributor.authorŞAHİN, ÖZLEM
dc.contributor.authorsOzdek S., Ucgul A. Y., Hartnett M. E., Akdogan M., Sen P., Bhende M., Besirli C. G., Karacorlu M., Dedania V., Parolini B., et al.
dc.date.accessioned2022-12-28T12:44:58Z
dc.date.available2022-12-28T12:44:58Z
dc.date.issued2022-10-10
dc.description.abstractPurpose: To report outcomes of pediatric patients with combined hamartoma of the retina and the retina pigment epithelium (CHRRPE) followed up conservatively or after pars plana vitrectomy (PPV). Methods: This retrospective multicenter study included sixty-two eyes of 59 pediatric patients with CHRRPE from 13 different international centers with an average age of 7.7±4.7 (0.3-17) years at the time of the diagnosis, and having undergone PPV or followed conservatively. At baseline and each visit, visual acuity values, optical coherence tomography (OCT) for features and central foveal thickness (CFT), and tumor location were noted. Lesions were called as zone 1, if it involves the macular and peripapillary area, and the others were called as zone 2 lesions. Results: Twenty-one eyes of 20 patients in the intervention group and 41 eyes of 39 patients in the conservative group were followed for a mean of 36.2±40.4 (6-182) months. BCVA improved in 11 (68.8%) of 16 eyes in the intervention group and 4 (12.9%) of 31 eyes in the conservative group (p<0.001). The mean CFT decreased from 602.0±164.9 μm to 451.2±184.3 μm in the intervention group, while it increased from 709.5±344.2 μm to 791.0±452.1 μm in zone 1 eyes of the conservative group. Posterior location of tumor, irregular configuration of the foveal contour and ellipsoid zone defect in OCT, subretinal exudate and prominent vascular tortuosity were associated with poor visual acuity. Conclusions: Vitreoretinal surgery is safe and effective in improving vision and reducing retinal distortion in zone 1 CHRRPE in children.
dc.identifier.citationOzdek S., Ucgul A. Y., Hartnett M. E., Akdogan M., Sen P., Bhende M., Besirli C. G., Karacorlu M., Dedania V., Parolini B., et al., "Combined Hamartoma of the Retina and Retinal Pigment Epithelium at Pediatric Age: Surgical versus Conservative Approach.", Retina (Philadelphia, Pa.), 2022
dc.identifier.doi10.1097/iae.0000000000003652
dc.identifier.issn0275-004X
dc.identifier.urihttps://journals.lww.com/retinajournal/Abstract/9900/Combined_Hamartoma_of_the_Retina_and_Retinal.180.aspx
dc.identifier.urihttps://hdl.handle.net/11424/284505
dc.language.isoeng
dc.relation.ispartofRetina (Philadelphia, Pa.)
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcombined hamartoma of the retina and the retina pigment epithelium
dc.subjectpediatric age
dc.subjectpars plana vitrectomy
dc.subjectretina
dc.subjectretinal pigment epithelium
dc.subjectsurgery
dc.subjectamblyopia treatment
dc.titleCombined hamartoma of the retina and retinal pigment epithelium at pediatric age: surgical versus conservative approach
dc.typearticle
dspace.entity.typePublication
local.avesis.ide73a5c82-f521-4f97-aeac-770be9fb32be
local.indexed.atPUBMED
relation.isAuthorOfPublication581efa4d-787b-4068-8d43-59e0733124d5
relation.isAuthorOfPublication.latestForDiscovery581efa4d-787b-4068-8d43-59e0733124d5

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