Publication:
Association between bactericidal/permeability increasing protein (BPI) gene polymorphism (Lys216Glu) and inflammatory bowel disease

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dc.contributor.authorEREN, FATİH
dc.contributor.authorsAkin, Hakan; Tahan, Gulgun; Ture, Filiz; Eren, Fatih; Atug, Ozlen; Tahan, Veysel; Hamzaoglu, Ismail; Imeryuz, Nese; Tozun, Nurdan; Hamzaoglu, Hulya Over
dc.date.accessioned2022-03-14T09:51:34Z
dc.date.available2022-03-14T09:51:34Z
dc.date.issued2011-02
dc.description.abstractBackground: Increasing Increasing evidence suggests that innate immune system may have a key role in the pathogenesis of the inflammatory bowel disease (IBD). Bactericidal/permeability increasing protein (BPI) has an important role in the recognition and neutralization of gram-negative bacteria by host innate immune system. The polymorphism on BPI gene called Lys216Glu is on the suspected list of IBD pathogenesis. Methods: We studied the Lys216Glu polymorphism on BPI gene, in a Turkish IBD patient population. A total of 238 IBD patients; 116 Crohn's disease (CD) and 122 ulcerative colitis (UC), besides 197 healthy controls were included in this study. Results: The Glu/Glu genotype and allele frequencies were found to be statistically higher compared to healthy control group not only in CD patients [P: 0.03, OR: 1.87 (CI 95% 1.02-3.42) and P: 0.00001 (OR: 2.07 CI 95% 1.47-2.91) respectively] but also in UC patients [P: 0.0002, OR: 2.71 (CI 95% 1.53-4.80) and P: 0.00002 (OR: 2.71 CI 95% 1.53-4.80) respectively]. Conclusions: BPI polymorphism (Lys216Glu) is associated both to CD and UC. Our findings differ from the two Western European studies; one without any association and the other indicating an association only with CD. Our study is the first one reporting a novel association between BPI gene mutation (Lys216Glu) and UC. (C) 2010 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.crohns.2010.08.008
dc.identifier.issn1873-9946
dc.identifier.pubmed21272798
dc.identifier.urihttps://hdl.handle.net/11424/243348
dc.identifier.wosWOS:000288822300003
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofJOURNAL OF CROHNS & COLITIS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectInflammatory bowel disease
dc.subjectBactericidal/permeability increasing protein
dc.subjectPathogenesis
dc.subjectPolymorphism
dc.subjectANTINEUTROPHIL CYTOPLASMIC ANTIBODIES
dc.subjectCROHNS-DISEASE
dc.subjectULCERATIVE-COLITIS
dc.subjectINNATE IMMUNITY
dc.subjectVARIANTS
dc.subjectMUTATION
dc.subjectTOLL
dc.subjectAUTOANTIBODIES
dc.subjectSUSCEPTIBILITY
dc.subjectPATHOGENESIS
dc.titleAssociation between bactericidal/permeability increasing protein (BPI) gene polymorphism (Lys216Glu) and inflammatory bowel disease
dc.typearticle
dspace.entity.typePublication
local.avesis.id30520fbe-0c94-487e-a432-28d085de90d0
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage18
oaire.citation.issue1
oaire.citation.startPage14
oaire.citation.titleJOURNAL OF CROHNS & COLITIS
oaire.citation.volume5
relation.isAuthorOfPublication4bc77d63-5aa7-4c67-8d60-12778ea963b1
relation.isAuthorOfPublication.latestForDiscovery4bc77d63-5aa7-4c67-8d60-12778ea963b1

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