Publication: Development of a new ultrasound scoring system to evaluate glandular inflammation in Sjögren's syndrome: an OMERACT reliability exercise
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2022-08-03
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Abstract
© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.OBJECTIVE: The aim of this exercise from the OMERACT Ultrasound subgroup on Sjögren\"s syndrome was to develop and assess the reliability of a consensus-based semiquantitative colour Doppler US scoring system for pathologic salivary gland vascularization in patients with primary Sjögren\"s syndrome (pSS). METHODS: Using the Delphi method, a colour Doppler semiquantitative scoring system for vascularization of bilateral parotid and submandibular glands was developed and tested in static images and on patients (9 pSS patients and 9 sonographers). Intra-reader and inter-reader reliability of grading the salivary glands were computed by weighted Cohen and Light\"s kappa analysis, respectively. RESULTS: The consensus-based semiquantitative score was: grade 0, no visible vascular signals; grade 1, focal, dispersed vascular signals; grade 2, diffuse vascular signals detected in 50% of the gland. In static images, the intra- and inter-reader reliability showed excellent kappa values (95% CI) of 0.90 (0.87, 0.93) and 0.80 (0.74, 0.84), respectively, for all four salivary glands together. In patients, the intra- and inter-reader reliability for all four salivary glands together was kappa = 0.84 (0.73, 0.92) and 0.70 (0.64, 0.76), respectively. CONCLUSION: The consensus-based colour Doppler US scoring for the evaluation of salivary gland vascularization in pSS showed a good inter-reader reliability and excellent intra-reader reliability in static images and in patients. The clinical application of the developed scoring system should be tested in clinical settings.
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Tıp, Temel Eczacılık Bilimleri, Dahili Tıp Bilimleri, İç Hastalıkları, İmmünoloji ve Romatoloji, Eczacılık, Yaşam Bilimleri, Sağlık Bilimleri, Temel Bilimler, Medicine, Basic Pharmaceutics Sciences, Internal Medicine Sciences, Internal Diseases, Immunology and Rheumatology, Pharmacology and Therapeutics, Life Sciences, Health Sciences, Natural Sciences, Klinik Tıp (MED), Yaşam Bilimleri (LIFE), Klinik Tıp, Farmakoloji ve Toksikoloji, ROMATOLOJİ, FARMAKOLOJİ VE ECZACILIK, Clinical Medicine (MED), Life Sciences (LIFE), CLINICAL MEDICINE, PHARMACOLOGY & TOXICOLOGY, RHEUMATOLOGY, PHARMACOLOGY & PHARMACY, Romatoloji, Farmakoloji (tıbbi), Rheumatology, Pharmacology (medical), primary Sjogren's syndrome, salivary gland vascularization, colour Doppler ultrasound, scoring system, COLOR DOPPLER SONOGRAPHY, CLASSIFICATION CRITERIA, SALIVARY-GLANDS, CONSENSUS, primary Sjögren’s syndrome
Citation
Hočevar A., Bruyn G. A. , Terslev L., De Agustin J. J. , MacCarter D., Chrysidis S., Collado P., Dejaco C., Fana V., Filippou G., et al., "Development of a new ultrasound scoring system to evaluate glandular inflammation in Sjögren's syndrome: an OMERACT reliability exercise", Rheumatology (Oxford, England), cilt.61, sa.8, ss.3341-3350, 2022