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Novel levan and pNIPA temperature sensitive hydrogels for 5-ASA controlled release

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dc.contributor.authorTOKSOY ÖNER, EBRU
dc.contributor.authorsOsman, Asila; Oner, Ebru Toksoy; Eroglu, Mehmet S.
dc.date.accessioned2022-03-12T20:32:48Z
dc.date.available2022-03-12T20:32:48Z
dc.date.issued2017
dc.description.abstractLevan based cross-linker was successfully synthesized and used to prepare a series of more biocompatible and temperature responsive levan/N-isopropyl acrylamide (levan/pNIPA) hydrogels by redox polymerization at room temperature. Volume phase transition temperature (VPTT) of the hydrogels were precisely determined by derivative differential scanning calorimetry (DDSC). Incorporation of levan into the pNIPA hydrogel increased the VPTT from 32.8 degrees C to 35.09 degrees C, approaching to body temperature. Swelling behavior and 5-aminosalicylic acid (5-ASA) release of the hydrogels were found to vary significantly with temperature and composition. Moreover, a remarkable increase in thermal stability of levan within hydrogel with increase of pNIPA content was recorded. The biocompatibility of the hydrogels were tested against mouse fibroblast L929 cell line in phosphate buffer saline (PBS, pH 7.4). The hydrogels showed increasing biocompatibility with increasing Levan ratio, indicating levan enhanced the hydrogel surface during swelling. (C) 2017 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.carbpol.2017.01.097
dc.identifier.eissn1879-1344
dc.identifier.issn0144-8617
dc.identifier.pubmed28363576
dc.identifier.urihttps://hdl.handle.net/11424/234433
dc.identifier.wosWOS:000399261900008
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofCARBOHYDRATE POLYMERS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLevan
dc.subjectN-Isopropyl acrylamide
dc.subject5-ASA
dc.subjectTemperature sensitive hydrogel
dc.subjectControlled drug release
dc.subjectRedox polymerization
dc.subjectN-ISOPROPYLACRYLAMIDE
dc.subjectHALOMONAS-SMYRNENSIS
dc.subjectDRUG-RELEASE
dc.subjectDEGRADATION
dc.subjectDELIVERY
dc.subjectDEXTRAN
dc.subjectFILMS
dc.subjectCELLULOSE
dc.subjectPOLYMERS
dc.titleNovel levan and pNIPA temperature sensitive hydrogels for 5-ASA controlled release
dc.typearticle
dspace.entity.typePublication
local.avesis.idafa83352-6946-45c3-8192-da2984fdb784
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
local.journal.quartileQ1
oaire.citation.endPage70
oaire.citation.startPage61
oaire.citation.titleCARBOHYDRATE POLYMERS
oaire.citation.volume165
relation.isAuthorOfPublication6118e9e4-a58e-429b-bbec-4f73a3089a2b
relation.isAuthorOfPublication.latestForDiscovery6118e9e4-a58e-429b-bbec-4f73a3089a2b

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