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Nonalcoholic Steatohepatitis Score is an Independent Predictor of Right Ventricular Dysfunction in Patients with Nonalcoholic Fatty Liver Disease

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dc.contributor.authorSÜNBÜL, MURAT
dc.contributor.authorsSunbul, Murat; Kivrak, Tarik; Durmus, Erdal; Akin, Hakan; Aydin, Yucel; Ergelen, Rabia; Yilmaz, Yusuf; Agirbasli, Mehmet
dc.date.accessioned2022-03-12T20:26:34Z
dc.date.available2022-03-12T20:26:34Z
dc.date.issued2015
dc.description.abstractObjectiveNonalcoholic fatty liver disease (NAFLD) is associated with increased risk of cardiovascular disease and impaired left ventricular (LV) function, yet the impact of NAFLD on right ventricular (RV) function remains unclear. We investigate the RV functional properties in patients with NAFLD. MethodsNinety consecutive patients with the diagnosis of biopsy-proven NAFLD and 45 age- and sex-matched controls were included. All patients underwent an echocardiographic examination. RV function was evaluated by two-dimensional (2D) speckle-tracking echocardiography (STE). ResultsMean fibrosis stage and nonalcoholic steatohepatitis (NASH) scores were 1.31.1 and 5.2 +/- 1.6, respectively. NAFLD patients displayed decreased RV function compared to controls. NAFLD patients with liver fibrosis (67 patients) had significantly lower RV function assessed by GLS (global longitudinal strain) compared to patients without liver fibrosis (18.9 +/- 3.4% vs. 21.6 +/- 2.3%, P<0.001). NASH score 5 was associated with lower RV-GLS (18.9 +/- 3.1% vs. 21.0 +/- 3.4%, P=0.006). NASH score inversely correlated with RV-GLS (r=-0.370, P<0.001) such as patients with impaired RV-GLS (<19%) showed significantly higher NASH score compared to normal RV-GLS group (5.8 +/- 1.4 vs. 4.8 +/- 1.7, P=0.009). Logistic regression analysis revealed that NASH score was an independent predictor of impaired RV function in patients with NAFLD. ConclusionsPatients with NAFLD have impaired RV function. NASH score inversely correlates with RV-GLS and independently predicts impaired RV function in patients with NAFLD.
dc.identifier.doi10.1111/1755-5922.12145
dc.identifier.eissn1755-5922
dc.identifier.issn1755-5914
dc.identifier.pubmed26202098
dc.identifier.urihttps://hdl.handle.net/11424/233485
dc.identifier.wosWOS:000361492200007
dc.language.isoeng
dc.publisherWILEY-HINDAWI
dc.relation.ispartofCARDIOVASCULAR THERAPEUTICS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectnonalcoholic fatty liver disease
dc.subjectRight ventricular function
dc.subjectspeckle-tracking echocardiography
dc.subjectSPECKLE TRACKING ECHOCARDIOGRAPHY
dc.subjectMETABOLIC SYNDROME
dc.subjectDEFORMATION PARAMETERS
dc.subjectDIASTOLIC DYSFUNCTION
dc.subjectLOGISTIC-REGRESSION
dc.subjectCARDIOVASCULAR RISK
dc.subjectNATURAL-HISTORY
dc.subjectSAMPLE-SIZE
dc.subjectTHICKNESS
dc.subjectDESIGN
dc.titleNonalcoholic Steatohepatitis Score is an Independent Predictor of Right Ventricular Dysfunction in Patients with Nonalcoholic Fatty Liver Disease
dc.typearticle
dspace.entity.typePublication
local.avesis.id6a3a95e5-c798-4b3b-b7d4-06d6d0b05608
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage299
oaire.citation.issue5
oaire.citation.startPage294
oaire.citation.titleCARDIOVASCULAR THERAPEUTICS
oaire.citation.volume33
relation.isAuthorOfPublicationfa3b72e8-14b9-47e2-87d8-814128a7b685
relation.isAuthorOfPublication.latestForDiscoveryfa3b72e8-14b9-47e2-87d8-814128a7b685

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