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Non-atopic asthma in children is related to maternal bronchial hyperreactivity

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dc.contributor.authorCEYHAN, BERRİN
dc.contributor.authorsOzdemir, Cevdet; Ceyhan, Berrin B.; Yazi, Didem; Eifan, Aarif O.; Yesil, Ozlem; Bahceciler, Nerin N.; Barlan, Isil B.
dc.date.accessioned2022-03-12T17:33:32Z
dc.date.available2022-03-12T17:33:32Z
dc.date.issued2008
dc.description.abstractData on the pathogenic mechanisms underlying the development of non-atopic asthma in children are scarce. Our aim was to evaluate the association and compare the atopic status, pulmonary functions, bronchial hyperresponsiveness and serum total immunoglobulin E (IgE) levels of parents of atopic and non-atopic asthmatic children by using objective methods. Fifty-one asthmatic children aged 4-16 yr and their parents were included into the study. Initially the American Thoracic Society's Respiratory Disease questionnaire inquiring data on symptoms of asthma, rhinitis and past medical history was filled in. Afterwards, skin prick test with aeroallergens, pulmonary function and methacholine bronchial provocation tests and serum sampling for total IgE level determinations were carried out. Bronchial hyperresponsiveness to methacholine was significantly more common in the mothers of non-atopic children compared to those of atopic ones, although no significant difference was observed in the skin prick test reactivity, pulmonary function test parameters and serum IgE levels. Questionnaire data revealed that the presence of asthmatic symptoms such as wheezing and phlegm and doctor-diagnosed asthma were more common in the mothers of non-atopic children. Meanwhile, asthmatic symptoms were also found to be significantly more common in fathers of non-atopic children. Logistic regression analyses revealed that maternal PC20 was the only predictive factor for the risk of displaying non-allergic asthma in children. The results demonstrate that among the risk factors studied, maternal bronchial hyperreactivity was associated with the development of asthma in non-atopic children.
dc.identifier.doi10.1111/j.1399-3038.2007.00620.x
dc.identifier.eissn1399-3038
dc.identifier.issn0905-6157
dc.identifier.pubmed18397409
dc.identifier.urihttps://hdl.handle.net/11424/228864
dc.identifier.wosWOS:000254669200007
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofPEDIATRIC ALLERGY AND IMMUNOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbronchial hyperresponsiveness
dc.subjectparental atopy
dc.subjectpediatric asthma
dc.subjectSERUM IGE LEVELS
dc.subjectRISK-FACTORS
dc.subjectINHALANT ALLERGENS
dc.subjectINTRINSIC ASTHMA
dc.subjectGENETIC-FACTORS
dc.subjectCHILDHOOD
dc.subjectMETHACHOLINE
dc.subjectREACTIVITY
dc.subjectADAM33
dc.subjectATOPY
dc.titleNon-atopic asthma in children is related to maternal bronchial hyperreactivity
dc.typearticle
dspace.entity.typePublication
local.avesis.id27c4e249-a6dd-44b9-8d7e-197daa5759f0
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage254
oaire.citation.issue3
oaire.citation.startPage248
oaire.citation.titlePEDIATRIC ALLERGY AND IMMUNOLOGY
oaire.citation.volume19
relation.isAuthorOfPublication14f2d015-b03a-45e7-bb38-e82572308bca
relation.isAuthorOfPublication.latestForDiscovery14f2d015-b03a-45e7-bb38-e82572308bca

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