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Bioinspired scaffold induced regeneration of neural tissue

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dc.contributor.authorEKREN, NAZMİ
dc.contributor.authorsAltun, Esra; Aydogdu, Mehmet O.; Togay, Sine O.; Sengil, Ahmet Z.; Ekren, Nazmi; Haskoylu, Merve E.; Oner, Ebru T.; Altuncu, Nese A.; Ozturk, Gurkan; Crabbe-Mann, Maryam; Ahmed, Jubair; Gunduz, Oguzhan; Edirisinghe, Mohan
dc.date.accessioned2022-03-14T10:20:19Z
dc.date.available2022-03-14T10:20:19Z
dc.date.issued2019-05
dc.description.abstractIn the last decade, nerve tissue engineering has attracted much attention due to the incapability of self-regeneration. Nerve tissue regeneration is mainly based on scaffold induced nanofibrous structures using both bio and synthetic polymers. The produced nanofibrous scaffolds have to be similar to the natural extracellular matrix and should provide an appropriate environment for cells to attach onto. Nanofibrous scaffolds can support or regenerate cells of tissue. Electrospinning is an ideal method for producing the nanofibrous scaffolds. In this study, Bacterial cellulose (BC)/Poly (epsilon-caprolactone) (PCL) blend nanofibrous scaffolds were successfully prepared by electrospinning for nerve tissue induced repair. The produced nanofibrous scaffolds contain well defined interconnected nanofiber networks with hollow micro/nanobeads. Firstly, in-vitro biocompatibilities of nanofibrous scaffolds were tested with L2929 murine fibroblasts and improved cell adhesion and proliferation was observed with polymer blends compared with PCL only. The primary cell culture was performed with dorsal root ganglia (DRG) cells on nanofibrous samples and the samples were found suitable for enhancing neural growth and neurite outgrowth. Based on these results, the BC/PCL (50:50 wt.%) nanofibrous scaffolds exhibited nerve-like branching and are excellent candidate for potential biomimetic applications in nerve tissue engineering regeneration.
dc.identifier.doi10.1016/j.eurpolymj.2019.02.008
dc.identifier.eissn1873-1945
dc.identifier.issn0014-3057
dc.identifier.urihttps://hdl.handle.net/11424/244361
dc.identifier.wosWOS:000467668800012
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofEUROPEAN POLYMER JOURNAL
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBacterial cellulose
dc.subjectPolycaprolactone
dc.subjectElectrospinning
dc.subjectNerve regeneration
dc.subjectBiomimetic
dc.subjectPERIPHERAL-NERVE REGENERATION
dc.subjectPOLY-EPSILON-CAPROLACTONE
dc.subjectBACTERIAL CELLULOSE
dc.subjectNANOFIBROUS SCAFFOLDS
dc.subjectELECTROSPUN NANOFIBERS
dc.subjectSTEM-CELLS
dc.subjectFABRICATION
dc.subjectBIOCOMPATIBILITY
dc.subjectBIOMATERIALS
dc.subjectCOMPOSITES
dc.titleBioinspired scaffold induced regeneration of neural tissue
dc.typearticle
dspace.entity.typePublication
local.avesis.idbd74e5f2-f2fd-46cf-94d4-91e72b2d89bc
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages11
local.journal.quartileQ1
oaire.citation.endPage108
oaire.citation.startPage98
oaire.citation.titleEUROPEAN POLYMER JOURNAL
oaire.citation.volume114
relation.isAuthorOfPublicationbf8fa87c-9f12-4134-a6e3-274f1ec50ed9
relation.isAuthorOfPublication.latestForDiscoverybf8fa87c-9f12-4134-a6e3-274f1ec50ed9

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