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Synthesis, characterization, antituberculosis activity and computational studies on novel Schiff bases of 1,3,4-thiadiazole derivatives

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dc.contributor.authorKARAKUŞ, SEVGİ
dc.contributor.authorsTurk, Sevda; Karakus, Sevgi; Maryam, Arooma; Oruc-Emre, Emine Elcin
dc.date.accessioned2022-03-14T09:27:29Z
dc.date.available2022-03-14T09:27:29Z
dc.date.issued2020-10-15
dc.description.abstractA series of novel Schiff bases were designed and synthesized by the condensation of 1,3,4-thiadiazoles that contain aromatic primary amine and variously substituted benzaldehydes. The synthesized compounds were screened for their antituberculosis activity against Mycobacterium tuberculosis H(37)Rv using BACI EC 460 radiometric system. Among the tested compounds, 2-(4-nitrophenyl)amino-5-[4-(3-(4-phenoxy))benzylideneaminophenyl]-1,3,4-thiadiazole (3n) showed the highest inhibitory activity (80%). The activities of the newly synthesized Schiff bases were higher in comparison to those of intermediate products 2-(4-aminophenyl)-5-aryl/alkylamino-1,3,4-thiadiazoles (2a-l). The computational studies were also performed to estimate drug-like profile of the compounds by using QikProp analysis.
dc.identifier.doi10.35333/jrp.2020.232
dc.identifier.issn2630-6344
dc.identifier.urihttps://hdl.handle.net/11424/243145
dc.identifier.wosWOS:000592829900001
dc.language.isoeng
dc.publisherMARMARA UNIV
dc.relation.ispartofJOURNAL OF RESEARCH IN PHARMACY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSchiff bases
dc.subject1,3,4-thiadiazoles
dc.subjectantituberculosis activity
dc.subjectMycobacterium tuberculosis H(37)Rv
dc.subjectADME
dc.subjectTUBERCULOSIS
dc.subjectHYDRAZIDE
dc.subjectCOMPLEXES
dc.subjectDFT
dc.titleSynthesis, characterization, antituberculosis activity and computational studies on novel Schiff bases of 1,3,4-thiadiazole derivatives
dc.typearticle
dspace.entity.typePublication
local.avesis.id45c63233-22ae-4918-b28e-189a7bd3535a
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
local.journal.numberofpages8
oaire.citation.endPage800
oaire.citation.issue6
oaire.citation.startPage793
oaire.citation.titleJOURNAL OF RESEARCH IN PHARMACY
oaire.citation.volume24
relation.isAuthorOfPublicationc93b8083-3f67-4147-bd81-8587eaba18ad
relation.isAuthorOfPublication.latestForDiscoveryc93b8083-3f67-4147-bd81-8587eaba18ad

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